Disease Risks & Drug News / Public health

This file includes links to papers published by Eubios Ethics Institute, and some other organizations, in the first section. Next it includes topical extracts from EJAIB and EEIN between January 1994 - 2006 (older news items are in separate files). Last date of updating is referenced in the main News page. Latest news and papers is at the bottom of each of the two sections.

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Information on smoking

Pharmacy and Bioethics - Towards the "Doctor Of Pharmacotherapy" in a Drugstore - Olga A. Khroutski and Konstantin S. Khroutski EJAIB 12 (May 2002), 97-103.

EJAIB 14 (2004), 61-63 Cyber-pharmacies and ethical concerns over marketing drugs online - Vinod Scaria
Hans-Martin Sass, Emergency Management in Public Health Ethics: Triage, Epidemics, Biomedical Terror and Warfare EJAIB 15 (Sept. 2005), 161-7.

Arthur Saniotis, Health, Illness and Medical Bioethics: An Islamic Perspective EJAIB 16 (May 2006), 71-6.


The medically recommended weekly dose of alcohol is 21 units for men and 14 units for women (1 dose is about a glass of wine); BMJ 307 (1993), 1373-4. Any more is much more likely to result in health damage. Excessive drinking is shown to cause neuronal damage in Lancet 342 (1993), 1201-4. A paper looking at the question of freedom of choice and the nature of addiction is G. Oddie, "Addiction and the value of freedom", Bioethics 7 (1993), 373-401.

Passive smoking has been labelled as a health risk and carcinogenic. A paper supporting this is S.S. Hecht et al., "A tobacco-specific lung carcinogen in the urine of men exposed to cigarette smoke", NEJM 329 (1993), 1543-6. This shows that a carcinogen was inhaled into the body due to passive smoking. Letters on the subject of smoking are in NEJM 329 (1993), 1580-2, JAMA 270 (1993), 1742-3, 2536; BMJ 307 (1993), 1381-4. The commercial aspects of smoking advertisements using Joe Camel, the AMA, are debated in JAMA 270 (1993), 1978-82. A study of smoking in Japanese doctors found that the incidence of smoking is less than the general public and calls for them to be more active in preventing smoking, AJPH 83 (1993), 1640.

A study of the cause of deaths in the USA found that about 400,000 deaths in 1990 could be attributed to tobacco, 300,000 to diet, 100,000 to alcohol, 35,000 to guns, 30,000 to sexual behaviour, 25,000 to motor vehicles and 20,000 to illicit use of drugs; JAMA 270 (1993), 2207-12.

An opinion article on "how reliable are doctor's prescriptions?" is in Bioethics Research Notes 5 (4) (1993), 29-30. It concludes that they are not very reliable, this is especially true in countries where doctors profit from the prescriptions directly, such as in Japan. A study on the prescribing of drugs in the UK that is relevant is BMJ 307 (1993), 1118-20.

There are a few recent studies on the harmful effects of radiation on health; BMJ 307 (1993), 959-66, 966-71, 1391-7. However, the link between leukemia and radiation from Sellafield nuclear reprocessing plant is "fragile" according to a recent UK government study, BMJ 307 (1993), 955, 1094; Science 262 (1993), 648-9; Lancet 342 (1993), 981, 1106; New Scientist (4 Sept, 1993), 6; (16 Oct 1993), 6; (30 Oct 1993), 10; (13 Nov 1993), 25-9. The link was too weak to be successfully brought in court. A study of US personnel exposed to nuclear tests has found increased incidence of thyroid cancer, JAMA 270 (1993), 2076-82. The latest data from Chernobyl shows a dramatic increase in thyroid cancer in children, BMJ 307 (1993), 1230. Several papers on "Why we need nuclear power" are in New Scientist (6 Nov, 1993), 3, 14-5, 34-9. In India the government is establishing controls on the use of medical x-ray equipment, BMJ 307 (1993), 1094. Germany is still dealing with cases where patients at Hamburg University hospital were exposed with very high doses of radiation, Lancet 342 (1993), 544.

The link between EMF fields and certain childhood cancer is weak, but appears to exist according to the most extensive studies, those from Nordic countries, Lancet 342 (1993), 1295-6.

Two European studies support the view that consumption of vegetables high in flavonoids, or b-carotene may reduce the risk of coronary heart disease, A.F.M. Kardinaal et al., "Antioxidants in adipose tissue and risk of myocardaal infarction: the EURAMIC study", Lancet 342 (1993), 1379-84; M.G.L. Hertog et al., "Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly study", Lancet 342 (1993), 1007-11. The recent guidelines from the FDA on dietary supplements, and labelling requirements, are summarised in FDA Consumer (Nov 1993), 8-13. Letters on the reduction in incidence in heart disease associated with vitamin E use are in NEJM 329 (1993), 1424-6. Studies on the relationship between stress and hypertension and death are in JAMA 270 (1993), 2439-43; BMJ 307 (1993), 1102-5. The benefits of moderate exercise are discussed in NEJM 329 (1993), 1730-1.

A paper showing that the daily use of sunscreen in Australia reduces skin cancer is in NEJM 329 (1993), 1147-51, 1193-4. A report from the Council of Scientific Affairs of the AMA on silicone gel breast implants is in JAMA 270 (1993), 2602-8.

A study of US gun ownership has found that rather than being protective the ownership of guns is associated with increased risk of homicide by a family member, NEJM 329 (1993), 1084-91; 1117-8. A plea for prevention of fatal bicycle accidents by use of helmets is in J. Pediatric Surgery 28: 214-6. They found that 89% of fatalities were caused by head injuries.

A US court has dismissed a claim by farmers that a CBS programme presented false data on the dangers of the pesticide Alar, Science 262 (1993), 35. A pesticide link to breast cancer is reported in New Scientist (25 Sept, 1993), 4. On the subject of carcinogens, see letters in Science 262 (1993), 638-9. The costs and benefits of lead screening are discussed in JAMA 270 (1993), 2054-5, 2555-7; Science 262 (1993), 323.

Book reviews of K.R. Foster et al. (eds), Phantom Risk: Scientific Inference and the Law (MIT Press 1993, 457pp., US$40) and L.A. Cole, Element of Risk: The Politics of Radon (AAAS Press 1993, 246pp, US$30) are in Nature 367 (1994), 227-8. Both these books suggest that the name of science is being misused in claiming that there is scientific risk associated with substances whose effects are very difficult to measure. The risks discussed include animal carcinogen testing, radiation for electromagnetic fields (EMF), and chemicals. The book on radon is extremely critical of the way standards are set in the USA, but suggests there is some risk. A recent Swedish study suggesting little risk from radon to lung cancer is G. Pershagen et al., "Residential radon exposure and lung cancer in Sweden", NEJM 330 (1994), 159-64; Science 263 (1994), 465.

A book review of V. Beral et al. (eds) Childhood Cancer and Nuclear Installations (BMJ 1993, 453pp., US$54) is in Nature 367 (1994), 421. Comments on the study reported last issue of 20,000 British soldiers exposed to radiation in various tests that found no extra cancer as a result, are in Science 262 (1993), 1976. An analysis of the possible mechanisms that might link paternal exposure to radiation to disease is in Nature 367 (1994), 678-80. A book review on the topic of nuclear weapons is Nature 367 (1994), 63-4.

A specific mutation in the p53 gene is proposed as a measure of the exposure to UV light in a paper, H. Nakazawa et al., "UV and skin cancer: Specific p53 gene mutation in normal skin as a biologically relevant exposure measurement", PNAS 91 (1994),, 360-4. A letter on the relationship between dioxin and cancer is in Science 263 (1994), 14. Measurement of lead in bone (as a result of work or pollution exposure) is possible through a technique reported in JAMA 271 (1994), 197-203, 239-40.

A commentary on the declining health in Eastern Europe is in Nature 367 (1994), 313-4. The main factors may not be economic, but lifestyle factors of tobacco abuse, diet, alcohol and obesity. Half of the gap may be due to tobacco alone. A review of the development of smoking policy is in Science 262 (1993), 1750-1, and also on risk from smoking, Science 262 (1993), 1375. Recently McDonalds has announced no smoking will be allowed in its US restaurants. A book review of J.C. Burnham, Bad Habits. Drinking, Smoking, Taking Drugs, Gambling, Sexual Misbehavior and Swearing in American History (New York University Press 1993, 385pp.) is in Science 262 (1993), 2067-8. The new program and emphasis on preventive medicine, Science 262 (1993), 1508-9, is long overdue in most countries. Diet is discussed in regard to health in Nature 367 (1994), 404; AJPH 84 (1994), 14-9; JAMA 271 (1994), 98; and coffee-associated osteoporosis in JAMA 271 (1994), 280-3. Targets for improvement in Scottish persons diet have been set, BMJ 308 (1994), 80. A paper looking at the role of free radicals and aging at the biochemical level is Biotechnology 12 (1994), 37-40.

An opinion on the reliability of doctor's prescriptions is in Bioethics Research Notes 5(Dec 93), 29-30. It discusses the reliability of randomised clinical trials, and calls for continued study of drug safety after it enters the real world of use. A similar conclusion is made in NEJM 329 (1993), 2029-30. Treatments to avoid blood-clotting (TPA, streptokinase etc) may be underused despite their proven efficacy; Scientific American (Feb 1994), 11-2. A review of the uses of aspirin is in FDA Consumer (Jan/Feb 1994). Letters on anabolic steriod abuse in the USA are in JAMA 271 (1994), 347-8.

Papers reporting the prevention of head injuries from wearing bicycle helmets are in BMJ 308 (1994), 173-6, 177; MJA 159 (1993), 719-21, 783-6.

The Russian Federation has signed a memorandum of understanding with the US FDA effectively making the FDA the safety channel for all US produced drugs and products to be distributed in Russia; GEN (1 March 1994), 35. This is saves the time and money of checking new products. European standardisation is described in TIBTECH 11 (1993), 375-8; and a new publication from WHO is WHO Expert Committee on Biological Standardization, 43rd Report (WHO Technical Report Series 840, 1994).

The results of Swedish studies which allow estimates of the risks of radon in homes causing lung cancer suggest current standards used in the UK are safe enough for non-smokers; Nature 368 (1994),97-8; but there is still uncertain data for smokers.

The study discussed in the animal genetic engineering section above on fruit fly supported the free radical theory of aging. This suggests that antioxidants would slow down aging; Science 263 (1994), 1094, 1128+. A book review of D.W.E. Smith, Human Longevity (Oxford University Press 1993, 175pp., £27.50) is in Nature 368 (1994), 199. A nutrition and dietary fat study in Manitoba, Canada is reported in Can. J. Public Health (1993), 389+. The possibilities for lowering population cholesterol concentrations are discussed in BMJ 308 (1994), 351-2. Letters on the economic and social consequences of being overweight in adolescence are in NEJM 330 (1994), 647. The benefits of apple eating have been claimed for centuries, and discussions are in NEJM 330 (1994), 797-8.

Some studies describe significant correlations between sugar intake and destructive activity, and hyperactivity, but a study finding no strong link is M.I. Wolraich et al., "Effects of diets high in sucrose or aspartame on the behaviour and cognitive performance of children", NEJM 330 (1994), 301-7, 355-6.

The benefits of aspirin for reducing vascular diseases is reported in studies in Antiplatelet Trialists' Collaboration, "Collaborative overview of randomised trials of antiplatelet treatment. I. Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients", BMJ 308 (1994), 81-106, ++, 71-2. Aspirin is effective at least at 325mg, and may be at lower levels, and is as good as any other agent tested.

A letter on the Delaney clause (which prohibits the addition of any carcinogen at any level to food) and cancer risk is Nature 368 (1994), 580, 582. On the topic of dioxin and cancer, Science 263 (1994), 1545-6. Environmental causes of breast cancer (see also environment section), are discussed in S.S. Epstein, "Environmental and occupational pollutants are avoidable cause of breast cancer", Int. J. Health Sciences 24: 145-50. Also on cancer risk, BMJ 308 (1994), 545. Data on cancer rates in Britain finds that except for smoking related cancer, there is no general increase in cancer, but several specific tumours are increasing, BMJ 308 (1994), 705-8. On US trends in cancer, and Sweden, which suggest some extra cancer rates, JAMA 271 (1994), 431-7. See also Lancet 343 (1994), 494-5; and book reviews in NEJM 330 (1994), 443-5.

The FDA is considering labelling nicotine, thus including cigarettes, as drugs; BMJ 308 (1994), 617; Science 263 (1994), 1555-6; Nature 368 (1994), 83-4, 382; Lancet 343 (1994), 664. When cigarettes are made, the manufacturers spray nicotine onto the dried cut leaves, and it is claimed that they increase the amount to increase the chance the smokers will become addicted. The US is already trying to stop teenagers smoking, BMJ 308 (1994), 677; JAMA 271 (1994), 643. On the politics of antismoking laws, J. Health Politics, Policy & Law 18 (1993), 787-820. A study in Michigan finds that reducing smoking would increase employment, JAMA 271 (1994), 771-6. The elimination of smoking adverts in Western Australia, and other action, is reported in BMJ 308 (1994), 395-8. A summary of action in New South Wales, Australia to stop smoking is in Lancet 343 (1994), 349. African efforts are summarised in BMJ 308 (1994), 189-91. A list of magazines that have stopped advertising tobacco is in JAMA 271 (1994), 571-6. A survey in Japanese life insurance companies found 27% of the female employees smoked, whereas the prevalence throughout Japan in women is 14% - asking what they sell; Lancet 343 (1994), 675.

The dangers of second-hand smoke have been further clarified with an animal study showing the development of arterial plaques in chickens exposed to smoke, that resemble those found in human smokers, which can lead to heart disease; Science 264 (1994), 30. As reported last issue, a urine test has shown that chemicals derived from smoke are found in non-smokers exposed to smoke, New Scientist (29 Jan 1994), 16. A Chinese study is Y. He et al., "Passive smoking at work as a risk factor for coronary heart disease in Chinese women who have never smoked", BMJ 308 (1994), 380-4; and a UK study suggesting mother's smoking is a more important risk factor for children than fathers, is D.G. Cook et al., "Passive exposure to tobacco smoke in children aged 5-7 years: individual, family, and community factors", BMJ 308 (1994), 384-9. See letters in JAMA 271 (1994), 583-5. Predicting smoking cessation may be possible during the first two weeks behaviour with the nicotine patch, JAMA 271 (1994), 589-4; see also p. 595-600.

A editorial saying that no smoker should be denied urgent heart surgery is in BMJ 308 (1994), 607-8. Several months ago the major gene responsible for bone mass loss was isolated (see previous issues; New Scientist (29 Jan 1994), 14), and the effects of lifetime smoking for a woman is estimated to be a 10% loss of bone mass in J.L. Hopper & E. Seeman, "The bone density of female twins discordant for tobacco use", NEJM 330 (1994), 387-92, 430-1. The pill may raise cervical cancer rate among smokers, New Scientist (8 Jan 1994), 16; and smoking reduces sperm density by about 13-17%; F&S 61 (1994), 35-43. A paper on the human costs of tobacco use is in NEJM 330 (1994), 907-12.

A general description of the US drug laws is in NEJM 330 (1994), 356-60. A study suggesting high tolerance to alcohol puts people at risk for alcoholism is reported in Amer. J. Psychiatry (Feb 1994), Science 263 (1994), 1094-5. The misuse of alcohol and drugs among elderly people may lead to special management schemes; BMJ 308 (1994), 608-9. In the USA about 50% of all deaths are "avoidable", i.e. being related to risk behaviour (it may be better to use the term "early deaths"); JAMA 271 (1994), 659-61; Lancet 343 (1994), 594.

The commercialisation of sunscreen, and there effectiveness, is discussed in New Scientist (22 Jan 1994), 21-2; and some link between frequent sunburn and melanoma has been shown; BMJ 308 (1994), 75-6; Lancet 343 (1994), 484. Radiation risk and cancer is debated in BMJ 308 (1994), 60; NEJM 330 (1994), 442; Lancet 343 (1994), 111, 598-9.

Germany is seeking a European ban on British beef based on fears of bovine spongiform encephalopathy; Nature 368 (1994), 178.

The risks of autoimmune disease from silicone breast implants is discussed in Lancet 343 (1994), 229, 353-4. US companies have began to pay for health damage caused by implants, Lancet 308: 555-6. There is also controversy in France, Lancet 343 (1994), 722.

Comments against making cycle helmets mandatory are in CMAJ 149 (1993), 342-4. Data suggesting helmets lower serious injury is BMJ 308 (1994), 173-6, 177. Letters on guns and homicide are NEJM 330 (1994), 365-7, 373-5; JAMA 271 (1994), 495; and on violence in the media, Lancet 343 (1994), 127-8. Lead poisoning from shooting clubs is another risk, Lancet 343 (1994), 6-7.

The US is still discussing the classification of nicotine as a drug, which is under much pressure from the tobacco producers, New York Times (29 June 1994), A1, 20; and on the US debate, JAMA 271 (1994), 1387-90, 1562; BMJ 308 (1994), 1444; JAMA 271 (1994), 1575-6; Nature 369 (1994), 691-2. The level of nicotine is claimed to be manipulated also, New Scientist (23 April 1994), 6; Nature 369 (1994), 696. The company that is said to have doubled the natural level is Brown and Williamson Tobacco Co. The FDA found its genetically modified tobacco plant, which was also being bred to increase nicotine levels. There were also claims that companies hid data about harm of nicotine, Science 264 (1994), 196-7, 766-7.

From July, Canada became the first country in the world to ban smoking from all flights of its national airlines, New York Times (29 June 1994), A20. Many countries have national bans, but this is the beginning of international bans. Canadian airlines fears losses on Japan routes, as at the moment there are only two other non-smoking flights to Japan (on Singapore Airlines). In Japan in 1993 lung cancer surpassed stomach cancer as the leading cause of death for men; Yomiuri Shinbun (24 June), 34. A comparison of the rates of cigarette smoking is D.E. Nelson et al., "Trends in cigarette smoking among US physicians and nurses", JAMA 271 (1994), 1273-5. The greatest reduction took place in 1974. Issues in how to stop young people using tobacco are discussed in AJPH 84 (1994), 543-7; Lancet 343 (1994), 1109-10; BMJ 308 (1994), 1241.

The second part of a paper on the human costs of tobacco use is NEJM 330 (1994), 975-80. On passive smoking and carcinogens, NEJM 330 (1994), 1016-7. Workplace restrictions on smoking may reduce the smoking of the smokers also, according to AJPH 84 (1994), 773-8.

Letters on the question of vascular surgery in smokers are BMJ 308 (1994), 978-9, 1435-6. Some of the arguments include the lower recovery rate if people continue to smoke after the surgery.

The link between EMF and breast cancer is debated in papers in the J. National Cancer Institute (15 June); Science 264 (1994), 205, 1658; BMJ 308 (1994), 1162-3. A study of women electrical engineers, and telephone installers, found a 38% higher incidence of breast cancer than other workers, but there is much debate as to whether there is any significance. Occupational health is discussed in JAMA 271 (1994), 1691-2; BMJ 308 (1994), 1115-6. Accusations that the French government have tried to muzzle a researcher who has studied the hazards of glycol ethers, by firing him, are in Science 264 (1994), 898-9, 1076.

The dangers of old nuclear reactors in the UK are discussed in New Scientist (7 May 1994), 4. The government has rejected a call for an inquiry into nuclear waste, Nature 369 (1994), 346; despite the finding that death from leukemia in workers was related to radiation dose, Lancet 343 (1994), 1220; Radiat. Res. 138: 224-38. The collecting of DNA from all babies born over the next five years in Cumbria has been approved by the West Cumbria research ethics committee. A letter on paternal exposure to radiation, and sperm damage is Lancet 343 (1994), 973-4. Protests in Japan against plutonium may have been involved with some recent decisions to cut back production goals, Nature 369 (1994), 596; and uranium fuel is also causing debate with Germany; Nature 369 (1994), 89. Letters on the p53 mutations associated with radon are in Lancet 343 (1994), 1158-9; and on radon risks, Science 264 (1994), 1239-30.

A New York state department of health report suggests some breast cancer in older women was associated with a chemical plant close-by; BMJ 308 (1994), 1057-8. Genetic variation in clearance of carcinogens is reported in P. Vieis et al., "Genetically based N-acetyltransferase metabolic polymorphism and low-level environmental exposure to carcinogens", Nature 369 (1994), 154-7. On the topic of toxic risks: JAMA 271 (1994), 1292-3; Science 264 (1994), 183; on pesticide poisoning, AJPH 84 (1994), 731-6; Science 264 (1994), 499-500; on dangers of carcinogens in overdone red meat, AJPH 84 (1994), 856-8; and hot dogs, Science 264 (1994), 1255; on contrasting views of the risks of dioxin between the FDA and EPA, Science 264 (1994), 1071. The use of thalidomide among leprosy sufferers in Brazil is discussed in Time (13 June), 37; Lancet 343 (1994), 1041; BMJ 308 (1994), 1061, 1437-8.

The balance between privacy and public safety in drug testing for detecting illegal drugs or dangerous ones is debated in HCR 24(2): 17-27. On drug prohibition see JAMA 271 (1994), 1635-48; Lancet 343 (1994), 967. The public disgrace of Diego Maradona at the Soccer World Cup for drug use also heightens the problem of sports use of drugs. On alcohol use: BMJ 308 (1994), 1003-6; Lancet 343 (1994), 810. The effect of alcohol on sex hormones (testesterone) in women taking the pill has been found to be much greater than that on women not taking it, Nature 369 (1994), 711.

The FDA has announced its decision on Halcion, accusing Upjohn of misconduct, Lancet 343 (1994), 1216-7; BMJ 308 (1994), 1321-2. A book review of FDA food and drug approval is Nature 369 (1994), 27-8. Debate over the safety of the potential anticancer drug, tamoxifen, is delaying clinical trials, Science 264 (1994), 1524-7; BMJ 308 (1994), 1318. An NIH advisory panel has rejected the Persian Gulf syndrome, Nature 369 (1994), 8. The reasons for the deaths of 15 patients who received an experimental drug Sorivudine in Japan has been featured in many Japanese newspapers; Yomiuri Shinbun (23 June), 27; Nature 369 (1994), 697. They dies and others became sick due to the reactions with anticancer medicines they were taking. Japanese patients are often not told they have cancer, yet are given unknown drugs, and may also go to other doctors freely, increasing the chances of such a drug reaction.

A discussion of eating natural foods to obtain vitamins is Newsweek (25 April), 42-7; and on antioxidants, NEJM 330 (1994), 1148-9. A Tohoko University study has suggested b-carotene is useful to treat Alzheimer's; Yomiuri Shimbun (28 June 1994), 31. However, antioxidants may have dangers, Science 264 (1994), 500-1. A vitamin E supplement does not appear to reduce lung cancer in male smokers, and may actually make it worse; NEJM 330 (1994), 1029-35, 1080-1, 1608-9. The idea of taking vitamins while smoking seems contradictory to me - the best way to reduce the risk is to quit smoking! The difficulties of interpreting cholesterol data are debated in BMJ 308 (1994), 1025-9. A review is W.C. Willet, "Diet and health: What should we eat?", Science 264 (1994), 532-7. Also on food, FDA Consumer (May 1994), 15-9; Lancet 343 (1994), 1127-30. Bone density seems to be linked to increased milk consumption (calcium intake), BMJ 308 (1994), 939-41, 930-1; which reduces the risk of disability in later life, JAMA 271 (1994), 1093-8.

A settlement for payments for breast implant health damage is reported in Lancet 343 (1994), 845, 1153. On their potential danger to infants, Lancet 343 (1994), 1043-4. Cosmetic labels are discussed in FDA Consumer (May 1994), 20-1.

The benefits of exercise are shown in T.A. Lakka et al., "relation of leisure-time physical activity and cardiopulmonary fitness to the risk of acute myocardial infarction in men", NEJM 330 (1994), 1549-54. The wrong sort of exercise can cause harm, e.g. bungee jumping can cause visual loss, Lancet 343 (1994), 853. A review of preventive medicine is NEJM 330 (1994), 1589-95; also JAMA 271 (1994), 1301, 1566, 1704-5. Health risk behaviours in young US people are discussed in JAMA 271 (1994), 1311. A paper on the complex relationship between religion and health, is SSM 38 (1994), 1475-82.

A debate over what the safe level of blood alcohol concentration is for driving is in BMJ 308 (1994), 1055-6. They say less than 0.8g/l, the current level. However, the studies to find a safe level differ, and we could suggest that a much lower level be adopted. In some countries, such a Japan, a total ban on drinking is generally followed by drivers. A US study on the alcohol-related causes in traffic deaths is JAMA 271 (1994), 1397-8. Speed cameras have been linked to reduced deaths and slower driving, BMJ 308 (1994), 999, also 1176. Cycle helmets are called for in AJPH 84 (1994), 653-6; BMJ 308 (1994), 1164-5. Papers on child injury control include: AJPH 84 (1994), 537-9; J.A. Waller, "Reflections on half a century of injury control", AJPH 84 (1994), 664-70; BMJ 308 (1994), 1312-3. Drowning rates of infants in the USA have remained similar over the last ten years, despite the access to pool fencing, but deaths in older children have fallen, JAMA 271 (1994), 1606-8.

Papers on the subject of violence and how to reduce it include: AJPH 84 (1994), 539-41, 612-7; JAMA 271 (1994), 1147+1281-2.

On May 18, 1994 the Japan Pharmaceutical Manufacturers Association released guidelines aimed at eliminating some part of the corruption found in Japanese pharmaceutical research. The new guidelines apply to four main ares: research commissions that accompany requests for clinical tests; travel expenses for organising and attending study meetings; travel expenses for attending academic conferences to present test results; and donation of gifts and equipment and entertainment (Ross, C. "Japan's medical information transparency", Lancet 343 (1994), 1418-9.). In fact the MHW had reservations about the public release of the guidelines, as was reported in national newspapers. However the guidelines do not mention any penalties. The guidelines detail ways that have been used to pay extra rewards to health care institutions and health care professionals, and they are a significant part of the financial income for a significant number of facilities. For example, excessive amounts of money have been given to doctors for conducting clinical tests, to promote the claims of the drugs under development. Physicians have solicited large sums of money from some companies where the clinical trial success or failure will have large financial implications. All the necessary trials for drug approval are conducted at universities and research organisations, and there have been cases of bribery.

On May 20, 1994 the chairman of Japan's fourth largest pharmaceutical's wholesaler, resigned to take public responsibility for insider trading among employees, and for the sale of sorivudine, which has led to the deaths of 18 people. The company had reached settlements with 10 of the 23 families of patients who died or had serious consequences as a result of using it, by May 1994 (Ross, 1994). In this incident these court cases are avoided, and the families received compensation rapidly for Japanese malpractice cases. However, the government also imposed a penalty of a 105 day suspension of production at the Nippon Shoji Kaisha Ltd. Okayama prefecture factory (Japan Times, 2 Sept., 1994, 1). This penalty was in response to the company failing to report the deaths of two persons during clinical trials. This is the longest ever suspension of products because of an infringement of the Drugs, Cosmetics and Medical Instruments Law. Kyoto prefecture also decided not to purchase any of the 179 medicines or cosmetics that the company makes.

Sorivudine was an antivirus drug approved in 1993 for use in shingles, herpes zoster. The drug had especially severe side effects in some people who were taking anti-cancer medication (especially the drugs Tegafur and Doxifluridine), but many people are not told what medicine they are taking so they suffered. The problem of lack of knowledge of medicines that are consumed is much more general. The patients can read the number codes of drugs in books, but most drugs do not come with labels. The MHW also decided following this case to instruct drug manufacturers to provide doctors with detailed information concerning the side effects and toxicity of their products, in particular 12 of the 50 anticancer drugs used in Japan. Many of these drugs cause side effects yet are only effective in 20-30% of patients, and are not used overseas. One of the drugs included is a new drug, Irinotecan Hydrochloride, which was approved despite the deaths of 22 people during trials.

A discussion of drug trials is FDA Consumer (July 1994), 16-9; and a book review of M.W. DeGregorio & V.J.Wiebe, Tamoxifen and Breast Cancer, Yale University Press 1994, 112pp., US$10, is New Scientist (11 June 1994), 44. In the UK a court case on Halcion has been decided with benefits to UpJohn for libel in a BBC program, and to the opposing professor in a counter-libel case, BMJ 308 (1994), 1455-6; Lancet 343 (1994), 1422. Racial differences in blood vessel dilation are reported in New Scientist (2 July 1994), 7.

The US is still discussing the classification of nicotine as a drug, and it appears the FDA will regulate them in this way, GEN (August 1994), 41; Science 265 (1994), 863; New Scientist (13 Aug 1994), 10; NEJM 331 (1994), 123-5; BMJ 309 (1994), 7. The panel of the FDA set up to examine the question judged it to be addictive. The question is now to define the lowest level which is addictive, Nature 370 (1994), 402. Labelling is debated in JAMA 272 (1994), 312-4. Mississippi state is suing the 13 major US tobacco companies to pay for the tobacco-related medical costs incurred by the state; BMJ 308 (1994), 1455. India has proposed a law to ban all tobacco advertising, to prohibit smoking in public, and to ban the sale of tobacco within 100m of educational institutions, medical colleges and hospitals; BMJ 308 (1994), 1528-9.

Also on tobacco, BMJ 309 (1994), 59; Lancet 343 (1994), 1492; AJPH 84 (1994), 1081-93; Amer.J. Med.Sci. 308: 32-4. Smoking cessation is discussed in BMJ 308 (1994), 1478-82; JAMA 271 (1994), 1940-7; and the lack of efforts by Japanese doctors in CMAJ 150 (1994), 1673-4. Smoking in adolescence is a negative factor for obtaining high peak bone mass; BMJ 309 (1994), 230-5. Publications about environmental smoke exposure are reviewed in JAMA 272 (1994), 133-6, and a study showing increased risk of cancer in exposed nonsmokers is E.T.H. Fontham et al., "Environmental tobacco smoke and lung cancer in nonsmoking women. A multicenter study", JAMA 271 (1994), 1752-9.

Zurich is considering legalising the use of heroin among some addicts. Australia is also considering drug laws, BMJ 308 (1994), 1526-7. Letters on drugs are in NEJM 331 (1994), 126-9. However, in New York City a link between cocaine use and firearms is found, JAMA 272 (1994), 43-6. Is may be because of lack of money, and gang systems, but it makes a note of caution.

A paper reporting effects of Chernobyl in Berlin is K. Sperling et al., "Significant increase in trisomy 21 in Berlin nine months after the Chernobyl reactor accident: temporal correlation or causal relation?", BMJ 309 (1994), 158-62, 139-40. 12 cases were found instead of the expected 2 or 3, and the low iodine content of the Berlin diet is suggested as a cause for absorption of the radioactive iodine from Chernobyl. Thyroid cancer in children from Chernobyl is reported, Lancet 344 (1994), 184, 259. However, no extra childhood leukemia is reported in Finland or Sweden, BMJ 309 (1994), 151-4, 154-7. Chernobyl is also being still discussed in the media, BMJ 309 (1994), 208-9; and other Soviet radiation risks are mentioned in Scientific American (July 1995), 20-1. General childhood cancer links are discussed in a book review in BMJ 309 (1994), 136-7.

Increased thyroid cancer is reported in atomic bomb survivors in S. Nagataki et al., "Thyroid diseases among atomic bomb survivors in Nagasaki", JAMA 272 (1994), 364-70. See book reviews of James V. Neel's autobiography in JAMA 272 (1994), 407-8; New Scientist (9 July 1994), 42-3. A US-Japan joint research group has said that the DNA of descendents of atomic bomb survivors is not affected by the radiation their parents were exposed to, Yomiuri Shimbun (9 Aug 1994), 22. The financing of a radiation effects research center in Japan is discussed in Science 265 (1994), 727. Radon risks are debated in Lancet 344 (1994), 127-8, 143-4; Scientific American (Aug 1995), 14-5. EMF links are debated in Science 264 (1994), 1658. Prevention of skin cancer by avoiding the sun is called for in BMJ 309 (1994), 285-6.

A US federal court has approved the biggest liability settlement in US history, with US$4.25 billion awarded to the women who were damaged by silicone breast implants (1 Sept). There were objections because foreign women will receive 40-90% of the payments to US women. There are 90,000 women included, with 500 foreign, in the registrations to date. The range of personal claim varies from $104,000 to $1.4 million in the USA. Papers providing data on health damage of breast implants include S.E. Gabriel et al., "Risk of connective-tissue diseases and other disorders after breast implantation", NEJM 330 (1994), 1697-702; JAMA 272 (1994), 271-4; BMJ 309 (1994), 349. An alternative Soya bean oil breast implant has begun clinical trials in the USA, New Scientist (13 Aug 1994), 12.

Research suggests that by changing diet people can reduce the risk of cancer by one third or more, BMJ 308 (1994), 1610-4. The consumption of soya is one of the apparent benefits, New Scientist (9 July 1994), 14-5. The health effects of fat consumption are discussed in BMJ 309 (1994), 2-3, 11-5; Lancet 343 (1994), 1445, 344: 276. Overweight in the USA is increasing, JAMA 271 (1994), 1788-9, 272: 205-11, 238-9. Debate over the effects of sugar on children's behaviour is in NEJM 330 (1994), 1901-4. Doubts on the role of fibre and placebo in the effect of bran on constipation are in Lancet 344 (1994), 3. Baby milk formulas are discussed in Lancet 343 (1994), 1492. Bones of postmenopausal women can be aided by potassium bicarbonate, NEJM 330 (1994), 1776-81, 1821-2. Risks of alcohol consumption and where to place a safe limit are discussed in BMJ 308 (1994), 1549-52; New Scientist (2 July 1994), 12-3.

The trend to make more drugs available over the counter is discussed in Lancet 343 (1994), 1374-5; JAMA 272 (1994), 30-1; and on rational prescribing, MJA 160 (1994), 564-7. Beneficial effects of vitamin C have been claimed for emphysema, following hamster research, Science 265 (1994), 871; PNAS (1 August).

Pesticide harms are discussed in BMJ 308 (1994), 1520-1; Science 264 (1994), 1829-30; J. Public Health Med. 16: 141-4; and environmental estrogens in Science 265 (1994), 308-10. On thalidomide, Lancet 344 (1994), 196-7. On public health, Lancet 344 (1994), 141-2; AJPH 84 (1994), 1077-80. Cycle injuries and mandating helmet usage are discussed in BMJ 308 (1994), 1521-2, 1534-7, 1537-40; also Lancet 343 (1994), 1504.

Occupational disease is discussed in Lancet 344 (1994), 4-5; BMJ 308 (1994), 1581-2; Scientific American (Aug 1995), 89. Farm safety is debated in AJPH 84 (1994), 1171-7.

High levels of lead in wine made from vineyards in France around major roads have been found, and can be traced through vintage years, Lancet 344 (1994), 326. Lead poisoning is discussed in JAMA 272 (1994), 277-83, 284-91, 315-6; Lancet 343 (1994), 1495-6. There has been a substantial decline in blood lead levels in the USA, linked to replacement of lead in gasoline and in cans.

The WestLakes Research Institute in the UK, funded by British Nuclear Fuels is starting to collect a bank of blood and DNA samples from all the estimated 10,000 babies born in west Cumbria over the next 3-5 years; GenEthics News 2 (1994), 1-2. In addition to general genetics research they will also look at mutation rate. Samples will be taken with consent of parents from he umbilical cord.

The effects of radiation on children's leukemia are dismissed in BMJ 309 (1994), 501-5. On the general dangers of low level radiation, EST 28 (1994), 488-92A; Chernobyl, Nature 371 (1994), 556; and on radon, Lancet 344 (1994), 750-1. The Japanese radiation center funding is discussed in Science 265 (1994), 727. Beef irradiation is being called for in the USA to stop E. coli infections, Lancet 344 (1994), 397.

A study in the US finds that passive smoking increases by 20-70% the chance of heart disease, Lancet 344 (1994), 465. A report from the American Heart Association finding passive smoking affects the health of children is JAMA 272 (1994), 841. Also on smoking and ill-health, Lancet 344 (1994), 629-30; NEJM 331 (1994), 618; AJPH 84 (1994), 1235-42; and on cigarette regulation by the FDA, Science 265 (1994), 863-4. Drug policy is discussed in NEJM 331 (1994), 748-52, 537-9. On drinking alcohol, AJPH 84 (1994), 1402-6, 967-8; and on caffeine dependence, JAMA 272 (1994), 1043-8, 1065-6.

The Canadian silicone breast settlement is considered unfair, as it is less than US women, Lancet 344 (1994), 465-6; BMJ 309 (1994), 626-7. On studies of the leakage of silicone, Science 265 (1994), 1654.

Diet is discussed in Stevens, J. et al. "Attitudes toward body size and dieting: Differences between elderly black and white women", AJPH 84 (1994), 1322-5; Lancet 344 (1994), 461; BMJ 309 (1994), 555-7; NEJM 331 (1994), 8215-6. Free radicals and disease are discussed in Lancet 344 (1994), 721-4, 793-5, 796-8; NEJM 331 (1994), 611-4. The risk factors in lifestyle choice are debated in AJPH 84 (1994), 1214-7; JAMA 272 (1994), 568; Lancet 344 (1994), 390-1. The regulation of foods & drugs is discussed in Scientific American (Sept 1995), 99-101.

The Japanese ban on sorivudine, a drug against shingles, that reported last issue, is in BMJ 309 (1994), 627; Nature 371 (1994), 89-90. Questions about the anti-depression drug Prozac and cancer are in BMJ 309 (1994), 487; Scientific American (Sept 1995), 22-3. Diethylstilboestrol problems with cancer are still being reported, Brit. J. O&G 101 (1994), 748-50. Medical device risks and regulation is in JAMA 272 (1994), 955-6, 968-9. The WHO Criteria on medicinal drug promotion are in IDHL 45: 229-34. Children's use of drugs that are available over-the-counter is debated, Lancet 344 (1994), 754; and a US survey,JAMA 272 (1994), 1025-30, 1063-4.

Dioxins are detectable in the blood of Swedish phenoxy herbicide workers, Lancet 344 (1994), 611-2. Agent Orange is being linked with birth defects, Time (26 Oct), (17 Oct), 6. The risks of low levels of chemicals are debated in Science 265 (1994), 1157, 1507; Scientific American (Sept 1995), 112; Nature 371 (1994), 214. The EPA is campaigning for safer chemicals, Science 265 (1994), 1519; but it is being challenged on its decision that dioxins probably cause human cancer, Nature 371 (1994), 272. On the general dangers of industrial pollution, BMJ 309 (1994), 425-6. Mercury in fish is reviewed in FDA Consumer (Sept 1994), 5-8. Lead pollution is is falling, but still detectable, JAMA 272 (1994), 999; SSM 39 (1994), 757-66.

The problems of dental materials are discussed in BMJ 309 (1994), 620-2. Osteoporosis and exercise is reviewed in BMJ 309 (1994), 400-3; and benefits of milk consumption are reported in, AJPH 84 (1994), 1319-22.

Intervention for habitual drinkers may save lifes according to a study, NEJM 331 (1994), 513-7; and other drugs may be useful for testing, NEJM 331 (1994), 518-22. Cycle helmets are discussed in BMJ 309 (1994), 541-2.

A new European Medicines Evaluation Agency (EMEA) began to operate in London from 1 January; Gene Therapy Newsletter 4: 22- 3. It is established by EC Regulation 2309/93, which outlined the new European Community guidelines on the authorisation of medicinal products for human and veterinary use. A study of horsemeat imports from the USA has found they have caused worm infections in thousands of Europeans, New Scientist (1 Oct 1994), 5. Food control in the Caribbean is reviewed from a conference in IDHL 45 (1994), 391-3. On possible changes to the FDA see Biotech 13 (1995), 7, 25-9.

There is increasing evidence that asthma is related to traffic fumes, New Scientist (1 Oct 1994), 4. Traditional life in Navajos in the USA means smoky houses with increased respiratory disease. New fuel, namely roots to burn is being tried, New Scientist (15 Oct 1994), 11.

Shanghai has baned smoking in many indoor public places, BMJ 309 (1994), 1460; and New York City has also banned smoking (to take effect from April). A study showing that tobacco smoking kills about one in two of smokers is Doll, R. et al. "Mortality in relation to smoking: 40 years' observations on male British doctors",BMJ 309 (1994), 901-11, 889-91; New Scientist (15 Oct 1994), 4. The USA is still moving to make nicotine a regulated drug, New Scientist (13 Aug 1994), 10; NEJM 331 (1994), 1531-3. Studies finding tobacco money influences policy are Moore, S. et al. "Epidemiology of failed tobacco control legislation", JAMA 272 (1994), 1171-5 (US federal government); Glantz, S.A. & Begay, M.E. "Tobacco industry campaign contributions are affecting tobacco control policy- making in California", JAMA 272 (1994), 1176-82, 1217-8. More on smoking hazards, CMAJ 151 (1994), 508-11; CJPH 85: 82-109; BMJ 309 (1994), 937-9, 1036-7; Lancet 344 (1994), 942, 1357; JAMA 272 (1994), 1724.

A study in the UK found that women are more likely to change their purchases of tobacco if the price changes, Townsend, J. et al. "Cigarette smoking by socioeconomic group, sex, and age: effects of price, income, and health publicity", BMJ 309 (1994), 923-7. The removal of an advert from UK television because it appealled more to teenagers than adults is documented in Hastings, G.B. et al. "Cigarette advertising and children's smoking: why Reg was withdrawn", BMJ 309 (1994), 933-7. A study of the costs on work is Hocking, B. et al., "Cost to industry of illnesses related to alcohol and smoking. A study of Telecom Australia employees", MJA 161: 407-12. At least 25% of the sick leave was due to these two factors, and if it is the same for all workers in Australia the cost would be at least A$2 billion a year - mostly from smoke. Reasons why people smoke are discussed from a US survey in JAMA 272 (1994), 1648-9.

A study in Sweden has found that the drug simvastatin can safely lower cholesterol in older persons and reduce heart disease, Lancet 344: 1383-9. However a study finding little link between cholesterol and coronary heart disease in persons over 70 years age is JAMA 272 (1994), 1335-40, 1372-4. A study suggesting aging in men is associated with a lack of when to know how to stop eating, JAMA 272 (1994), 1601-6. A positive effect from consuming green vegetables in reducing chances of a type of blindness, macular degeneration, is reported, JAMA 272 (1994), 1413-20, 1455-6. Carotenoids were associated with a reduced risk (who said carrots are good for sight?). Also on diet and heart disease, Lancet 344 (1994), 1358. An Indian study showing higher incidence of heart disease in rural areas, which also correlated with less educated and increased smoking is Gupta, R. et al. "Educational status, coronary heart disease, and coronary risk factor prevalence in a rural population of India", BMJ 309 (1994), 1332-6. Counseling can improve health as shown in Dracup, K. et al. "Management of heart failure. II. Counseling, education, and lifestyle modifications", JAMA 272 (1994), 1442-6. See also a book review in Nature 372 (1995), 329.

The use of steroids in young Canadians is still increasing despite warnings, CMAJ 151 (1994), 844-6. Alcohol abuse is discussed in JAMA 272 (1994), 1672-7, 1733, 1782-7. The WHO has denounced any benefits of mild alcohol consumption, and said it is bad to give any good image to alcohol, BMJ 309 (1994), 1249; another study suggesting mild consumption is positive is Doll, R. et al. "Mortality in relation to consumption of alcohol: 13 years' observations on male British doctors", BMJ 309 (1994), 911-8. On drug use in young Australians, MJA 161 (1994), 566-8, 569-70; and a book review, Nature 372: 52-3. The problems of food additives in children's behaviour are discussed in MJA 161 (1994), 581-2.

Letters on breast implants are in NEJM 331 (1994), 1231-4; Lancet 344: 1451-2, 1499. These follow claims that there is little damage from the implants, in NEJM 330 (1994), 1697-702, as reported earlier.

German data has now been released after changes to the data protection law, and it links dioxin to immune system damage, New Scientist (10 Sept 1994). Dioxin and damage it causes are discussed in Science 266 (1994), 349-52, 1141-5, 1162, 1628-9. The EPA and environmental estrogens is discussed in letters in Science 266 (1994), 525-8. The role of doctors in environmental health debates is increasing, CMAJ 151 (1994), 1048-50.

The link between DNA damage and sunburn and UV light is becoming clearer, Lancet 344 (1994), 1499; Nature 372 (1995), 413-4, 730-1, Ziegler, A. et al. "Sunburn and p53 in the onset of skin cancer", Nature 372 (1995), 773-6.

The US radiation regulations are being changed, Science 266 (1994), 1311; though a study finding little error with current estimates of risk is IARC Study group on Cancer Risk among Nuclear Industry Workers, "Direct estimates of cancer mortality due to low does of ionising radiation: an international study", Lancet 344 (1994), 1039-43, 1037. Continued radioactive pollution at Dounreay in the UK is unexplained, New Scientist (26 Nov 1994), 4.

A library is being planned for the 250,000 documents so far assembled to look at the human radiation experiments in the USA, Science 266 (1994), 1467. Two book reviews of interest about the history of the atomic bomb are in Science 266 (1994), 466-8, 663-4. People who cleaned up Chernobyl have been found to have a higher rate of stomach and lung cancer, and several other diseases, BMJ 309 (1994), 1321, see also pp. 1298-301. In Japan all major parties have agreed with the plutonium recycling policy, Nature 372 (1995), 491. A study finding a high incidence of bone cancer linked to radium in drinking water is prompting further study to see whether the risk is significant and the radium should be removed, CMAJ 151 (1994), 565+. The dangers of radon from well insulated houses that are being made to protect the environment are discussed in Nature 372 (1995), 327.

A legal review from a US case is Annas, G.J. "When should preventive treatment be paid for by health insurance?", NEJM 331 (1994), 1027-30. On preventive health care, JAMA 272 (1994), 1315; BMJ 309: 1168, 1449; CMAJ 151 (1994), 521-2; IDHL 45 (1994), 394-6; NEJM 331 (1994), 1156-9;World Health Forum 15 (1994), 340-4. The health risks of low temperature are discussed in BMJ 309 (1994), 1029-30.

Ancient lead from smelting during the Roman Empire days has been detected in Greenland ice, New Scientist (1 Oct 1994), 14. A review finding only some intelligence loss in exposure to lead in children is BMJ 309 (1994), 1189-97. Air pollution and lung disease is reviewed in Lancet 344 (1994), 930-3.

The risks of anesthesia are decreasing in NSW, Australia, MJA 161: 585-93. Cats and leukemia are possibly linked if the cat is infected with feline leukemia virus, Lancet 344 (1994), 971-2.

The benefits of cycle helmets are discussed in Lancet 344 (1994), 965; JAMA 272 (1994), 1506-11, 1535-8; and on seat belt benefits, AJPH 84 (1994), 1732-7. The dangers of firearms are discussed in JAMA 272 (1994), 1246, 1406-9. A study showing increased injury risk in night workers is Lancet 344 (1994), 1137-39, 1099-100; and on workplace homicide in health workers in the USA, JAMA 272 (1994), 1686-8. Video-game epilepsy is reviewed in Lancet 344 (1994), 1102-3.

A report in French on the ethics of drug addiction from the French National Consultative Ethics Committee is in Les cahiers No.2, 3-53. Several papers on the ethics and law of drug abuse are JLME 22 (1994), 197-256. The issue of legalising marijuana for pain relief is also discussed in BMJ 309 (1994), 1532-3, and it is legal in ACT, Australia. A UK survey has found a great increase in people's knowledge of illicit drugs in the last 5 years, BMJ 310 (1995), 20-4.

On alcohol use, AJPH 84 (1994), 1913-7; Am. J. Psychiatry 151 (1994), 1723-34. A study of the French case of low heart disease associated with moderate drinking of red wine, which doesn't recommend its general use is Criqui, M.H. & Ringel, B.L. "Does diet or alcohol explain the French paradox?", Lancet 344 (1994), 1719-23. Vitamin E may be safer, and is discussed in Lancet 345 (1995), 170-5; NEJM 332 (1995), 1720-1.

In Japan, the Ministry of Health and Welfare has introduced some changes to the regulation of morphine, to make it easier to use. In 1983 only 40kg was used, in 1993, 504kg was used, but still some doctors are reported to be against it for reasons of lack of knowledge, fear of drug addition, pain relief being a sign of defeat in medical care, and the strict control; Yomiuri Shimbun (4 March 1995), 1.

Canada has revealed its plans for charging those who apply for regulatory permission for biotechnology or pharmaceutical products user fees, GEN (15 Jan 1995), 20. New risk assessment laws may be put in effect in the USA, Nature 373 (1995), 180; BMJ 310 (1995), 137. European medicine assessment following the establishment of the new agency is discussed in Lancet 345 (1995), 1-2.

Silicone breast implants are discussed in Lancet 345 (1995), 319. The psychology of breast implants is discussed in BMJ 309 (1994), 1649-52. Dental material effects are debated in BMJ 310 (1995), 58.

Ethical and etiquette issues regarding reducing the risk of cardiovascular disease are debated in Lancet 344 (1994), 1586-7. Stress is another factor, Lancet 344 (1994), 1713-4; Lancet 344 (1994), 1583-4; 345: 140-1. A book review of Marcus, A.I. Cancer from Beef. DES, Federal Food Regulation, and Consumer Confidence (John Hopkins Uni. Press, 1994, 235pp., US$38.50) is in Science 267 (1995), 394. Also on diet, NEJM 332 (1995), 339-40; Lancet 345 (1995), 269-7, 273-8. Calcium is discussed in JAMA 272 (1994), 1942-7.

Smoking and health is discussed in Lancet 344 (1994), 1627; 345: 315; BMJ 310 (1995), 124; JAMA 272 (1994), 1825-31. Diet also affects lung health, BMJ 310 (1995), 75-6. Asthma in New Zealand is discussed in Pearce, N. et al. "End of New Zealand asthma mortality epidemic", Lancet 345 (1995), 41-4, also p.2-3. The cases were linked to the drug fenoterol. See also NEJM 332 (1995), 133-8, 181-2. NZ has lost its Public Health Commission, Lancet 344 (1994), 1761.

Several studies of plants around the US Navy's 90km long submarine radio network antenna's have found enhanced growth, said to be sue to the electromagnetic radiation; Science 267 (1995), 451. A study finding that mercury increases the damage caused by radiation is introduced in EST 29 (1995), 18A. Lead screening is being reduced in the USA, Lancet 344 (1994), 1587-8 Dioxin risks and the EPA report (see also environment section) are discussed in EST 29 (1995), 24-5A+.

Reducing falls among elderly persons is discussed in NEJM 332 (1995), 268-9.

A report on the results of a meeting in Chelyabinsk, Russian in which the results of a 30 year study on the effects of plutonium pollution on cancer rates in persons living down a river were made public is Science 267 (1995), 1084-6. The data has much potential for developing better safety guidelines. There has been concern over the funding of future studies of the survivors of the Japanese atomic bombs, Science 267 (1995), 611, 1077; Nature 374 (1995), 106, but the National Academy of Sciences will continue to pay the US share of the project, Science 267 (1995), 951. In the UK, as mentioned last issue, there will be a DNA database set up in Cumbria around the Sellafield reprocessing plant, Nature Medicine 1 (1995), 105. There has been much controversy over the transport of radioactive materials in the open sea by Japan; Nature 374 (1995), 7; New Scientist (21 Jan, 1995), 9; (4 Feb), 7; and on the 21 March Chile forced the ship out of its waters fearing a pollution disaster with the plutonium. On general fears, Scientific American (March 1995), 28-9.

A review of Proctor, R.N. Cancer Wars: How Politics Shapes What We Know and Don't Know About Cancer (Basic Books 1995, 356pp., US$25) is Nature 374 (1995), 417-8. A mistake in asbestos regulations in the 1960s in UK buildings is likely to cause many deaths, and there is concern also about current regulations, New Scientist (11 March, 1995), 4. US lead regulations are being criticised again, Science 267 (1995), 1089-90; and on lead and intelligence, BMJ 310 (1995), 397. A letter on the difficulties of assessing low level risk exposures is Science 267 (1995), 603-4. Drinking water in Australia is also a hazard to a persons health, MJA 162 (1995), 115-6. On fungicide regulation, Science 267 (1995), 1080-1. A review is Meulenberg, E.P. "Immunoassays for pesticides", EST 29 (1995), 553-61. On public health in general, Lancet 345 (1995), 597-9, 636; Scientific American (April 1995), 124-30.

There is a growing use of medicinal plant substances in the US, which is causing the FDA to examine them more, JAMA 273 (1995), 607-9. An historical study of drug prescribing is in Marks, H.M. "Revisiting The origins of compulsory drug prescriptions", AJPH 85 (1995), 109-15. The dangers of suicidal abuse of drugs is discussed in MJA 162 (1995), 174-5. Assessment methods for drugs in general are also discussed in Nature 374 (1995), 204; Lancet 345 (1995), 375; AJPH 85 (1995), 10-3, 18-9; Int. J. Health Services 25 (1995), 153-65; and a review is Kessler, D.A. & Feiden, K.L. "Faster evaluation of vital drugs", Scientific American (March 1995), 48-54.

A study in New Zealand has found a significant decline in smoking among young people between 1960s and the 1990s, suggesting the efforts to change attitudes and smoking policies may be working, NZMJ 108: 85-8. A US study has found the rate of decline in smoking has decreased since 1985, especially among blacks, suggesting advertising campaigns are having some effect, AJPH 85 (1995), 34-40. There are also mixed results in the adult population, AJPH 85 (1995), 156-63, 183-92, 193-200, 201-8.

A study has found that non-smokers are more likely to develop heart disease than smokers from the same amount of smoke exposure, because their bodies have not built up resistance to the chemicals in the smoke, Japan Times (6 April 1995), 20. Smoking has now been linked to non-insulin dependent diabetes, BMJ 310 (1995), 555-9. In general on health affects, BMJ 310 (1995), 396.

Austria has made a draft law to ban smoking in many public buildings, but it is still to pass the Parliament. Japan is also considering tightening their smoking regulations for commercials, in response to a WHO call for more measures, Japan Times (30 March 1995), 3. New York City has passed a new law which has placed strict limits on where people can smoke (i.e. not in restaurants with more than 35 persons, nor sitting down in bars). A discussion of smoking policies in 8 US states is JAMA 273 (1995), 531. A Californian judge has ruled that the diversion of antismoking money to causes other than smoking prevention is illegal, JAMA 273 (1995), 610-1.

In the UK legal aid to help 200 ex-smokers make claims against the tobacco industry has been given to call in expert witnesses to assess the case, BMJ 310 (1995), 349. There is also a growing number of lawsuits in the USA, Lancet 345 (1995), 574.

The debate between moderation or abstinence for alcoholic recovery is debated in Newsweek (27 March), 49. Mortality and alcohol is debated in BMJ 310 (1995), 325-6; AJPH 85 (1995), 16-7, 61-6; Carmelli, D. et al. "World-War II-Veteran male twins who are discordant for alcohol consumption: 24 year mortality", AJPH 85 (1995), 99-101. They found 24 deaths in 24 years of follow-up among abstaining twins and 14 deaths among twins who were mild drinkers, and conclude there is some protective effect, however, that it is lost in smokers.

A discussion of whether there is an early origin of coronary heart disease risk is BMJ 310 (1995), 411-2, 423-7, 428-32, 432-6, 436-9. Immigrants from India have higher serum cholesterol concentration after living in the UK, which is not very surprising, Lancet 345 (1995), 405-9. However it can lead to health problems. A letter on the lack of knowledge about effects of stress is Lancet 345 (1995), 589. On obesity, Scientific American (March 1995), 34-5; AJPH 85 (1995), 20-5, 236-9; NEJM 332 (1995), 673-4. The amino acid requirements of diet can be guessed from the composition of the body, but ideally a better standard should be developed, PNAS 92 (1995), 300-4. Silicone breast implants may not result in increased connective tissue damage according to a UK study, Lancet 345 (1995), 642.

The paper by Goldsmith in this issue discusses radiation and health A call to ban atomic weapons is BMJ 310 (1995), 993-4; however, France has announced it will resume testing in the South Pacific. The French embassy in Australia was bombed, and the fire service decided not to respond since no human lives were in danger - so the fire burnt! It is a sign of the opposition to the tests in the South Pacific - but raises questions about the politicalisation of emergency services! Health effects of atomic bomb tests are discussed in Watanabe, K.K. et al. "Cancer mortality risk among military participants of a 1958 atmospheric nuclear weapons test", AJPH 85 (1995), 523-7; Nature Medicine 1 (1995), 190. The death and disease rate of children exposed in Chernobyl are discussed in NS (1 April 1995), 7; Nature 375 (1995), 365; Lancet 345 (1995), 1168; BMJ 310 (1995), 801.

The adverse health of uranium miners is reported in a study 23 years after the people stopped mining, Roscoe, R.J. et al. "Mortality among Navajo Uranium Miners", AJPH 85 (1995), 535-40. A German plutonium plant has been blocked, and the waste will be processed at Sellafield, NS (8 April 1995), 8. A discussion that supports radiation damage is Kinlen, L.J. et al. "Childhood leukemia and non-Hodgkin's lymphoma near large rural construction sites, with a comparison with Sellafield nuclear site", BMJ 310 (1995), 763-8. dismisses a general association between Sellafield radiation and paternal mutation damage is Tawn, E.J. "Leukaemia and Sellafield; is there a heritable link?", JMG 32 (1995), 251-6; BMJ 310 (1995), 1198. A comment in Japan against the Japanese policy on reprocessing is Japan Times (20 April 1995), 18. An editorial on nuclear power is Nature 375 (1995), 91-2.

Letters on cancer risk and electromagnetic fields are in Nature 375 (1995), 22-3; NS (18 March 1995), 18. They show the difficulty in finding any effect on gene expression, or biological explanation for the epidemiological data. A paper reporting a model on the survival of microbes after exposure to pulsed electrical fields is in J. Sci. Food Agric. 67 (1995), 93-9. Papers on the medical use of X-rays include BMJ 310 (1995), 614-5, 640-2.

A paper looking at the role of UV A in solar mutagenesis, i.e. not only UV B is involved, is PNAS 92 (1995), 2350-4. A study dismissing increased skin cancer in Chile is Schein, O.D. et al. "Ocular and dermatologic health effects of ultraviolet radiation exposure from the ozone hole in Southern Chile", AJPH 85 (1995), 546-50. A paper showing that the UV protection of cotton may increase after washing, perhaps by shrinking of the holes is MJA 162 (1995), 422-5.

An in vitro testing system to replace more animal tests is being sought, and a review of some FDA contracts is GEN (15 April 1995), 6-7; Science 268 (1995), 356-7. The FDA proposals to streamline drug testing are reviewed in GEN (1 April 1995), 3, 28; and a view from a patient is FDA Consumer (March 1995), 6-7. In general on the FDA, JAMA 273 (1995), 1066-7. Drug trials are discussed in BMJ 310 (1995), 1279, 1305-6; and cancer survival rates in JAMA 273 (1995), 1000; BMJ 310 (1995), 617, 1352-3.

A survey of the ability of doctor's to calculate drug doses found poor performance, BMJ 310 (1995), 1173-4. A study finding 11% of information from drug sales reps contradicted information available to them is JAMA 273 (1995), 1296-8. In the UK special licensing may be given for herbal medicines, BMJ 310 (1995), 1023-4. A UK hospital was banned from neonatal heart operations after bad performances, BMJ 310 (1995), 960, 1195. Risks of ulcers from aspirins are discussed in BMJ 310 (1995), 827-30.

A study finding the cause of the oxidative damage of smoking is Morrow, J.D. et al. "Increase in circulating products of lipid peroxidation (F2-isoprotanes) in smokers", NEJM 332 (1995), 1198. The claim that the tobacco industry makes jobs is refuted by a UK study, Tobacco and Jobs, which says that if 40% of smokers stopped smoking by the year 2000, the money could create up to 150000 new jobs; Lancet 345 (1995), 1360. A study on the number of deaths passive smoking at work causes is Environmental Research 68 (1995), 3-9; and on heart disease in passive smokers, Glantz, S.A. & Parmley, W.W. "Passive smoking and heart disease", JAMA 273 (1995), 1047-53. A study finding that the smoking and drinking habits of Aborigines are responsible for many of the excess deaths is MJA 162 (1995), 475-8. On stereotypes of aboriginal health, MJA 162 (1995), 553; and on the Australian Tobacco Institute's problems, BMJ 310 (1995), 620. However in the USA, a survey shows that black children are stopping the habit, in a 1993 survey, 4.4% of African Americans but 23% of whites, Newsweek (15 May 1995), 52. The black children often say smoking is not cool, it is a white thing. A letter from a Japanese doctor calling for a boycott of the Japan Tobacco Corporation which is now marketting anti-cancer drugs is, Lancet 345 (1995), 1314.

A review is Bartecchi, C.E. et al. "The global tobacco epidemic", SA (May 1995), 44-51. A study on the difficulties of implementing tobacco restrictions is JAMA 273 (1995), 805-7; and on Israelis law on cigarette labelling, Lancet 345 (1995), 977. The French ban on advertising has had several exceptions introduced, BMJ 310 (1995), 962. A study of cigarette smuggling in Europe finds that expensive brands are being moved, BMJ 310 (1995), 1393-7. A review of the US state claims against tobacco industry for their health expenditures are JAMA 273 (1995), 1080-1; and on use of California's tobacco tax for research on smoking, Lancet 345 (1995), 781. A review of an Institute of medicine report on how to stop childhood smoking which is the main cause of addiction is JAMA 273 (1995), 1326; and on children's attitudes in the UK to health, BMJ 310 (1995), 1029-33.

The rise of alcoholism in the Russian Federation is discussed in BMJ 310: 646-8. Studies reporting low alcohol intake has a lower risk of cardiovascular disease are Gronbaek, M. et al. "Mortality associated with moderate intakes of wine, beer, or spirits", BMJ 310 (1995), 1165-9; Fuchs, C.S. et al. "Alcohol consumption and mortality among women", NEJM 332 (1995), 1245-50. It makes us remember the old proverb, a little bit of wine helps the digestion! A letter on whether a doctor should counsel patients to drink is JAMA 273 (1995), 1415-6.

Letters on caffeine dependence are JAMA 273 (1995), 1417-9; Lancet 345 (1995), 1066. US parents can check their children for drug use, Newsweek (24 April 1995), 45. A mail order company in the UK is selling the US home testing kit to check whether children are using drugs, Sunday Telegraph (30 April 1995), 1. The success of drug abuse programs is shown in JAMA 273 (1995), 1106-12. A WHO report on the global use of cocaine is discussed in BMJ 310 (1995), 825-6.

The mysterious Gulf War syndrome could have been caused by combined effects of a pill to protect against nerve gas and an insect repellant, NS (22 April 1995), 5. The persistence of dioxin from Agent Orange is shown in Schecter, A. et al. "Agent Orange and the Vietnamese: The persistence of elevated dioxin levels in human tissues", AJPH 85 (1995), 516-22, p. 476-8. There is also potential problems from dioxin that is missing from chemical use elsewhere, Nature 375 (1995), 353-4. A biochemical basis for DDT harm is in Nature 375 (1995), 538-9, 581-5.

In the US a pesticide applicator who used an unapproved pesticide has been sentenced to 5 years in prison, FDA Consumer (May 1995), 33-4. Repeated exposure to organophosphates is linked to long term mental change in Stephens, R. et al. "Neuropsychological effects of long-term exposure to organophosphates in sheep dip", Lancet 345 (1995), 1135-9. Diethylstilbestrol is discussed in Science 268 (1995), 16-7; and estrogen in FDA Consumer (April 1995), 25-9.

A study of recycled drinking water safety is EST 29 (1995), 174-9A. Lead poisoning is discussed in AJPH 85 (1995), 528-34; BMJ 310 (1995), 1408-9. Environmental health risks are discussed in Lancet 345 (1995), 1035-6; AJPH 85 (1995), 481-3; and gene-environment links in AJHG 56 (1995), 821-3.

The costs of obtaining consent from children in child survey research is discussed in Science 268 (1995), 967-8. Physician's roles in public health are discussed in JAMA 273 (1995), 1150-1, 1561-2; BMJ 310 (1995), 889. A number of papers on public health are in the Annual Review of Public Health; see also: Lancet 345 (1995), 1050, 1158-60; BMJ 310 (1995), 1212; JAMA 273 (1995), 1123-9. On epidemiological studies, BMJ 310 (1995), 752-4; AJPH 85 (1995), 474-6, 484-91.

The lack of a system for monitoring the health effects of body implants is criticised in NS (12 March 1995), 12-3. On silicone breast implants, MJA 162 (1995), 432-4; NEJM 332 (1995), 1306-7. The US product liability system is not being reformed, despite calls for it for several years, Lancet 345 (1995), 1359. From 1 July, the new Product Liability Law will take effect in Japan.

On asthma in New Zealand, Lancet 345 (1995), 984-5. Asbestos and cancer links are stronger following a new UK study, NS (8 May 1995), 8. Occupational health and lung cancer is discussed in SSM 40 (1995), 961-75. On epilepsy and driving, BMJ 310 (1995), 885-6; and on occupational disease, BMJ 310 (1995), 1282.

A Harvard University study has suggested only vigorous exercise will lead to longer life, not gentle exercise, Lee, I.M. et al. "Exercise intensity and longevity in men. The Harvard Alumini Health study", JAMA 273 (1995), 1179-84; Time (1 May 1995), 51. However general fitness also has benefits, JAMA 273 (1995), 1093-8; Bulletin WHO 73 (1995), 135-6. Hip fracture risks are discussed in NEJM 332 (1995), 814-5; and on osteoporosis, JAMA 273 (1995), 1082; BMJ 310 (1995), 989-92.

The protective effects of green tea on heath are shown in Imai, K. & Nakachi, K. "Cross sectional study of effects of drinking green tea on cardiovascular and liver diseases", BMJ 310 (1995), 693-6. Diet and health are discussed in BMJ 310 (1995), 823, 901-4, 1075, 1280-1; NEJM 332 (1995), 977-82, 1024-5; Lancet 345 (1995), 1107-10; JAMA 273 (1995), 1329-31, 1429-35; AJPH 85 (1995), 622-4. A study finding no correlation between baseline lipoprotein(a) and risk of future stroke is JAMA 273 (1995), 1269-73; however, fruits and vegetables did help, Gillman, M.W. et al. "Protective effect of fruits and vegetables on development of stroke in men", JAMA 273 (1995), 1113-7, p. 1077-8. A Finnish study linking low cholesterol with depression is NS (29 April 1995), 10; Amer. J. Epidemiology (April). The cost analysis of the use of HGM-CoA reductase inhibitors in reducing heart disease is JAMA 273 (1995), 1032-8. A paper on why people diet is Biener, L. & Heaton, A. "Women dieters of normal weight: Their motives, goals and risks", AJPH 85 (1995), 714-7. Measures against the food disease listeriosis in the USA appear to have worked, JAMA 273 (1995), 1118-22. On vitamin E, Lancet 345 (1995), 737.

Efforts to harmonise regional \occupational health laws are in AJLM XXI (1995), 7-44. A discussion of European and FDA procedures is Biotechnology 13 (1995), 636-8; Nature 376 (1995), 713-4. The FDA has given another 5 years before prescription drugs should all have drug information available to give to patients, and providing three quarters of the patients with this information, JAMA 273 (1995), 1815-6. The incidence of adverse drug reactions is reviewed in JAMA 273 (1995), 29-34, 35-43. In Japan, the MHW has produced an interim report calling for drug monitoring after approval, in response to the Sorivudine deaths, Japan Times (18 July 1995), 2.

As is discussed in the genetic disease markers section below, one of the major genes causing obesity has been found; Science 269 (1995), 475-6, 540-9. Discussion of whether obesity in Britain is "gluttony or sloth" is in BMJ 311 (1995), 279, 437-9; and also on dieting, Nature 376 (1995), 557; Lancet 345 (1995), 1537-40. Health is also falling in Japan, with rising cholesterol, Japan Times (24 August 1995), 2. A Japan-US comparison finds cholesterol levels are related to heart disease mortality, Iribarren, C. et al. "Serum total cholesterol and mortality", JAMA 273 (1995), 1926-32; Verschuren, W.M.M. et al. "Serum total cholesterol and long-term coronary heart disease mortality in different cultures", JAMA 274 (1995), 131-6.

Vitamin C may help vascular disease risk reduction but a large study needs to be done, BMJ 310 (1995), 1548-9, 1559-63, 1563-6. Vitamin supplements may benefit some people, Lancet 346 (1995), 85-9; and vitamin A deficiency did not respond to increased green vegetables in a UK study, Lancet 346 (1995), 75-81. Inadequate vitamin D status is reported in elderly people across Europe, Lancet 346 (1995), 207-10. On healthy eating, BMJ 311 (1995), 1453-5; and antioxidants, Lancet 346 (1995), 36-8.

The use of molecular genetics studies on cancer genes to study radiation harm is discussed in Land, C.E. "Studies of cancer and radiation dose among atomic bomb survivors", JAMA 274 (1995), 402-7. Also on radiation damage: Chernobyl victims, JAMA 273 (1995), 408-12, 427-8. The future of radiation and health studies between Japan and USA is still uncertain, but some funding has been given, Science 268 (1995), 1835; Nature 376 (1995), 709. Book reviews of James N Yamazaki, J.N. with Fleming, L.B., Children of the Atomic Bomb: An American Physician's Memoir of Nagasaki, Hiroshima, and the Marshall Islands (398pp.) and Kenzaburo Oe, Hiroshima Notes, in BMJ 311 (1995), 398. See the environment section for nuclear protests against France; and scientific ethics section also. Dangers of medical radiation are the subject of a new book, claiming that they are linked to breast cancer, JAMA 273 (1995), 367+. A study finding little risk of radiologists for breast cancer is JAMA 273 (1995), 394-401. On using heavy ion radiation as a therapy for cancer, Nature Medicine 1 (1995), 606-7.

A review is Ames, B.N. et al. "The causes and prevention of cancer", PNAS 92 (1995), 5258-65. The Delaney clause, in the USA regulations that no carcinogen should be added to food, is soon to be updated, Nature 376 (1995), 109. The joint studies on dioxin effects between USA and Vietnam have found authorities in Vietnam resistant to passage of biological samples, Science 269 (1995), 298. Also on dioxin, EST 29 (1995), 302A. Chemical toxins are increasing and there is more likelihood to have disasters, SA (July 1995), 22-3. Skin cancer mechanisms are discussed in JAMA 273 (1995), 445; and on stress and disease, Lancet 346 (1995), 104-6; Nature 376 (1995), 785-8.

A small alcoholic drink every day does not appear to be linked to hypertension, Lancet 345 (1995), 1588; BMJ 311 (1995), 3-4; NEJM 332 (1995), 1782-3; MJA 162 (1995), 565. A call for marihuana to be considered a medicine is made in JAMA 273 (1995), 1875-6. The prescribing of heroin for users is debated in Holland, BMJ 310 (1995), 1625; and Australia, Sydney Morning Herald (10 July 1995), 1; MJA 163 (1995), 62. However, a study showing that fatal injuries among cocaine users after use accounts for many of the young persons deaths in New York city, and 27% of all residents receiving fatal injuries have cocaine in their blood, would make us cautious; NEJM 332 (1995), 1753-7.

Poland's lower house voted on 27 August to ban smoking in most public places. A study suggests 80% of Israel's workplaces comply with a smoking ban, BMJ 311 (1995), 1487-8. The effects of laws on smoking bans in US hospitals have been found to be effective, but still some hospitals are to comply, JAMA 273 (1995), 488-91, 491-4. A study of restaurants in a Texas city finds no decrease in sales after smoking bans, JAMA 273 (1995), 206-7. The FDA has said nicotine is a drug, Nature 376 (1995), 205, 539; BMJ 311 (1995), 211; NEJM 333 (1995), 186-8; Newsweek (21 August 1995), 21-2. The costs of smoking to lost work are seen in SSM 41 (1995), 437-46. Attitudes to smoking among young people in Holland differ between the poor and rich, SSM 41 (1995), 419-24. Smoking on the airline Qantas may soon end, following a judges decision to pay compensation to non-smokers forced to sit in smoking seats (sounds very familiar!), BMJ 311 (1995), 38-40.

On the dangers of smoking, BMJ 310 (1995), 1431-3; 311 (1995), 142-3; JAMA 273 (1995), 155-60, 199-202, 208-9, 214-5; Lancet 346 (1995), 64, 168-9, 261. Brown and Williamson, the tobacco company, has withdrawn its claim on one third of 4,000 pages of internal documents held at the Library of the University of California SF; Nature Medicine 1 (1995), 397-8. Legal tactics of this and other tobacco companies are reviewed in JAMA 273 (1995), 219-24, 225-33, 234-40, 241-7, 254-7.

Grain dust is another risk factor for chronic renal failure, Lancet 346 (1995), 7-11. Safety in the Australian coal industry is reviewed in MJA 162 (1995), 7. Asbestos risk is debated in Lancet 346 (1995), 304-6.

The US gun control debate and various studies on the effects of guns on death are in JAMA 273 (1995), 1739-41, 43, 49-67, 1781, 1788-93. Canadian gun control debate, CMAJ 152 (1995), 2024-6, 28. The results of sarin poisoning in Matsumoto, Japan are published in Lancet 346 (1995), 290-3, 260; and on the deaths in Tokyo subways, Lancet 345 (1995), 1446-7; JAMA 274 (1995), 379. The OM religious cult has been found to be involved in a range of activities, and the bodies of a lawyer who started to investigate them has been found 6 years after death and burial, following confession of one of the murderers.

On public health in general, Biotechnology 13 (1995), 724; JAMA 273 (1995), 1712-3; Lancet 346 (1995), 1611-5; and on the limits of epidemiology, Science 269 (1995), 164-9. Psychosocial disorders are rising among young people in Europe and North America, BMJ 310 (1995), 1429.

The dangers of estrogen therapy for women are discussed in Time (26 June 1995), 52-9; NEJM 332 (1995), 1589-93, 1638-9; JAMA 274 (1995), 137-42, 178-9; O&G 86 (1995), 306-16. A study that did not find incidence of breast disease from breast implants is Sanchez-Guerrero, J. et al. "Silicone breast implants and the risk of connective-tissue diseases and symptoms", NEJM 333 (1995), 1666-70. Higher sexual activity and use of doxorubicin (used against childhood cancer) are risk factors for cardiac abnormalities in women, NEJM 332 (1995), 1738-43. On women's health, BMJ 311 (1995), 270.

A US study showing that low cholesterol can predict coronary heart disease mortality is JAMA 274 (1995), 539-44; 575-7; but improvements in monitorring are also needed, JAMA 274 (1995), 801-6; NEJM 333 (1995), 740-1; AJPH 85 (1995), 1207-11. There is a US study suggesting a link between low cholesterol to violence via serotonin, Science 270 (1995), 237. Letters on the reduction of heart disease with fish intake are in NEJM 333 (1995), 937-8. On the merits of physical activity, JAMA 274 (1995), 533-5, 1132-3. Obesity is related to earlier death, Lancet 346 (1995), 636-7; NEJM 333 (1995), 677-85, 686-92, 723-4; and avoiding premature coronary deaths in Asians in Britain is discussed in BMJ 311 (1995), 1035-6. Genetic factors are discussed in Lancet 346 (1995), 708-9.

A study of schizophrenic patients linking welfare payment to purchases of cocaine is NEJM 333 (1995), 777-83, 794-6. Book reviews on the history of drug use are in Nature 377 (1995), 23-4. In the UK there is debate over the use of cannabis for medicine, and the Dutch guidelines on addictive medicine are being revised, Lancet 346 (1995), 761-2. The majority in the USA are against the use of marijuana, JAMA 274 (1995), 598-9. The effects of alcohol on the liver urge caution for drinkers, Lancet 346 (1995), 987. Guidelines for alcohol use are examined in Lancet 346 (1995), 716.

Aspirin has some protective effect against colon cancer, after a decade of use, Giovannucci, E. et al., "Aspirin and the risk of colorectal cancer in women", NEJM 333 (1995), 609-14; 656-7. Studies of aspirin use in diabetic patients have found only slight reduction in cardiovascular events, BMJ 311 (1995), 641-2. An extract from the bark of an East African tree has been found to be an anticancer substance, Nature Medicine 1 (1995), 1046-51; Lancet 346 (1995), 1028.

It is expected that bills to reform the Food and Drug Administration (FDA) will be introduced later in 1995 in the USA, Lancet 346 (1995), 981; Science 269 (1995), 1038-41. One of the international problems is the expense of drugs, especially under Orphan drug acts, Lancet 346 (1995), 917. On the pharmaceutical drug industry, BMJ 311 (1995), 1101-2. The FDA has approved a new drug, Rilutek for treating amyotrophic lateral sclerosis, Lancet 346 (1995), 897.

There is some increased risk of breast cancer in women with more than 5 years of use of hormonal supplements, BMJ 311 (1995), 699-700. A book review of Reducing Breast Cancer Risk in Women is NEJM 333 (1995), 885-6. Letters on epidemiology are in Science 269 (1995), 1325-9.

A US survey on human exposure to major environmental pollutants is reported in EST 29 (1995), 398-9A. Thalidomide is being used for several diseases in experiments, despite its known adverse affects on fetal growth because it may be effective in treating adult disease, SA (Nov 1995), 20-2; Science 269 (1995), 1340. There are a growing number of drugs which are used for applications that they are not approved for, Time (25 Sept 1995), 46-7.

A review is Davis, D.L. & Bradlow, H.L. "Can environmental estrogens cause breast cancer?", SA (Oct 1995), 166-72. A letter on effects of testosterone is Science 269 (1995), 1341, 3. Letters on dioxin use and effects in Vietnam are Science 270 (1995), 217.

An editorial criticising the flaws in carcinogen testing is Science 270 (1995), 215; and on the development of new criteria at the EPA, EST 29 (1995), 448-9A. An anticancer drug is being reviewed because it may cause cancer, Science 270 (1995), 19. There is some evidence to suggest fiberglass may cause cancer, SA (Nov 1995), 16-8. In France a minister has promised to clean up asbestos; BMJ 311 (1995),898. Silicosis is another disease that should be eliminated, AJPH 85 (1995), 1346-7. On breast implants and disease, NEJM 333 (1995), 526; Newsweek (13 Nov 1995), 75. A Nevada women has been awarded US$4 million in compensation for health damage in a record decision which challenges the rest of the many cases.

The history of the censorship of the casualty data from the atomic bombs in Japan is reported in Nishimura, S. "Censorship of the atomic bomb casualty reports in occupied Japan. A complete ban vs. temporary delay", JAMA 274 (1995), 520-2. A book review on the bombings is Science 270 (1995), 1455-7; BMJ 311 (1995), 1100-1. The Nobel Peace Prize 1995 was awarded to the campaign against atomic weapons, Nature 377 (1995), 564. On nuclear waste storage, Science 269 (1995), 906-7, 1653-7.

A report on the debate on the dangers of electromagnetic radiation is SA (Oct 1995), 26-31. A draft report from a panel of the National Council on Radiation protection and measurements includes some dangers of EMF radiation, Science 270 (1995), 911. There is no threshold given, but it urges due diligence in reducing exposure. However, studies have failed to find a link to mutation of the myc oncogene, Science 269 (1995), 1816-7.

A paper showing slow decay in the radiocesium in the air and deposits in Bavaria since Chernobyl is in Naturwissenschaften 82 (1995), 417-20. Thyroid cancer cases are one of the results in the Ukraine since the accident, Lancet 346 (1995), 719. A radioactive contamination incident at MIT is being investigated, Nature 377 (1995), 563; as is one in NIH, Science 270 (1995), 379.

There are legal battles in the USA over the moves to regulate nicotine as an addictive drug by the FDA, Lancet 346 (1995), 453; see also Lancet 346 (1995), 510, 704-5, 831; Nature 378 (1995), 124. Smoking has some affect on the thyroid gland, NEJM 333 (1995), 1001-2. The Bellagio statement on tobacco and sustainable development, and smoking in the developing world is in, CMAJ 153 (1995), 1109-10, 1111-6. A survey in China has found that smokers in China spend about 60% of personal income and 17% of household income on average on cigarettes, JAMA 274 (1995), 1232-4. The dangers of occupational passive smoking are reported in JAMA 274 (1995), 956-60. The Canadian Supreme Court has ruled 5-4 to overturn a 7 year ban on tobacco advertising, though the tobacco industry has said it will attempt to obtain a mutually acceptable way to resume advertising, Lancet 346 (1995), 893. Both taxes and media campaigns can be effective to reduce smoking, AJPH 85 (1995), 1218-22. A survey of smoker's rights publications is AJPH 85 (1995), 1212-7. Letters on smoking doctors: BMJ 311 (1995), 945.

The consequences of driving ability tests and sight for persons over 70 years is reviewed in JAMA 274 (1995), 1026-30, 1060. A discussion of how social policy affects children is Roberts, I. & Pless, B. "Social policy as a cause of childhood accidents: the children of lone mothers", BMJ 311 (1995), 925-8. They conclude provision of day care would avoid some accidents.

An editorial calling for a ban on boxing is Nature 377 (1995), 561-2. The US Air Force Academy has ceased to make boxing mandatory in response to medical protests, JAMA 274 (1995), 784. The use of helmets is discussed in JAMA 274 (1995), 939-42. Violence is discussed in JAMA 274 (1995), 1031-6; Lancet 346 (1995), 563-4, 971; CMAJ 153 (1995), 879, 1261+. The dangers and crime to humanity of land mines are shown in Lancet 346 (1995), 715, 721-4. In the Mozambique household survey up to 1.6% of people had casualties, with half being fatal. On the pursuit of war technology, Science 269 (1995), 1599-600.

The relationship of the doctor-patient relationship to the way that public health information can be passed on is explored in a UK study in Makoul, G. et al. "Health promotion in primary care: Physician-patient communication and decision making about prescription medications", SSM 41 (1995), 1241-54. Schools also have a role in public health campaigns, JAMA 274 (1995), 1195. Under the Community Health Law (Chiki Hoken Ho) introduced in 1994, the health centre system in Japan is being changed, and will complete implementation by April 1997; Lancet 346 (1995), 494. The Health Centre Law will be replaced, and the number of health care centres reduced, and a move made to municipal health care centres who will take over the responsibility of community screening programs. A review of UK public health is BME 111 (Sept 1995), 13-18.

Design of attractive buildings in a hospital may increase recovery rates, NEJM 333 (1995), 735-9. A review of environmental medicine issues is Lancet 346 (1995), 860. A book review of Chasing Dirt. The American Pursuit of Cleanliness, is Science 270 (1995), 859-60.

A review of a book on human responses to disaster (see also EJAIB 5 (1995), 113-5, papers by D.Macer and F.Leavitt) is on, Ursano, R.J. et al. eds. The structure of human chaos (Cambridge University Press 1994), in Lancet 346 (1995), 490-1.

An editorial discussing the public concepts of risks to health, especially given recent UK government statements, is BME 112 (1995), 1. Comments on the FDA are in the section on recombinant product safety, see also, Lancet 346 (1995), 1492; TIBTECH 13 (1995), 235-6. Letters on the use of animals to determine cancer risk are in Science 270 (111091-95), 2; and Tennant, R.W., "Identifying chemical carcinogens and assessing potential risk in short-term bioassays using transgenic mouse models", Environmental Health Perspectives 10 (1995), 942-7. On taxomifen trials, Science 270 (1995), 910. A drug has been banned in Italy, after being used for several years without testing, as anticancer drug, Nature Medicine 1 (1995), 982. The dangers of herbal remedies are discussed in NS (4 Nov 1995), 36-40. A commentary looking at the apparently slower rate of treatment discover between 1965 to 1995 is Nature Medicine 1 (1995), 1122-5. On Japan's unsafe drugs, BMJ 311 (1995), 1522.

There appear to be numerous effects on health due to Chernobyl, NS (9 Dec 1995), 14-5. Thyroid cancer rates are dramatically increased (up to 100-fold) in exposed children, though there are some questions over how much is due to increased attention to it, Lancet 346 (1995), 1223-4, 1482; NS (2 Dec 1995), 4. The future of Chernobyl reactors is uncertain, Science 270 (1995), 567. Results of health effects from uranium mining in West Bohemia are reported in Environmental Health Perspectives 10 (Suppl. 2, 1995), 55-7, also pp. 49-53.

A study has found no genetic instability in certain genomic elements from survivors of the Japanese atomic bomb blasts, Kodaira, M. et al. "Lack of effects of atomic bomb radiation on genetic instability of tandem-repetitive elements in human germ cells", AJHG 57 (1995), 1275-83, 1263-6. On resistance to radiation, Science 270 (1995), 1318; NS (9 Dec 1995), 18. French and British researchers have been debating the "safe" limits of radiation exposure for nuclear workers, NS (2 Dec 1995), 3, 10. In Russia it is claimed 8000 people die each year due to excess radiation received in medical examinations, BMJ 311 (1995), 1120; and a claim that 75% of breast cancer is due to medical irradiation in the USA is JAMA 274 (1995), 1762. The NIH radiation poisoning case has led to tightened rules, Nature 378 (1995), 757.

A book review on EMF radiation is NEJM 333 (1995), 1293-4; and debate in NS (7 Oct 1995), 4; (18 Nov), 74. There are several papers on EMF radiation and health studies in Environmental Health Perspectives 10 (Suppl. 2, 1995), 59-62,63-7, 69-74. A study of increased breast cancer in female flight attendants in Finland is suggested to be linked to increased immune reactivity following radiation exposure at higher altitude, Lancet 346 (1995), 1379.

Melanoma and sun exposure is debated in Lancet 346 (1995), 1224-5; MJA 163 (1995), 511-2; NZMJ 108 (1995), 344-6, 508-10. Diet and fat consumption is discussed in JAMA 274 (1995), 1350-1, 1423-5, 1450-5; BMJ 311 (1995), 1239-40, 1251-4, 1255-9, 1260-4; NZMJ 108 (1995), 447-9; NS (21 Oct 1995), 28. Adverse of salt are shown in a study in chimpanzees, Nature Medicine 1 (1995), 994-6, 1001-16. Diet is a predictor of overall survival in elderly people in Greece, BMJ 311 (1995), 1457-60. On coronary heart disease in women, NEJM 333 (1995), 1570-1. Homocysteine is found to be a marker of cardiovascular risk in JAMA 274 (1995), 1526-33. Osteoporosis still needs drugs for treatment, Nature Medicine 1 (1995), 1130-1. The limits of starvation were extended in Somalia with a body mass index (body weight in kg divided by height in metres squared) of less than 10 kg per square metre, Nature Medicine 1 (1995), 810-4.

Breast implants and connective tissue diseases are debated in NEJM 333 (1995), 1423-4; FDA Consumer (Nov 1995), 11-6; Int. J. Health Services 25 (1995), 573-92. A jury in Nevada awarded a woman US$14 million in compensation, but Dow chemicals is appealing, BMJ 311 (1995), 1388; Newsweek (13 Nov 1995), 75; Lancet 346 (1995), 1287. A survey in the UK finds more female doctors take hormone replacement than the general public, BMJ 311 (1995), 1399-401; see also pp. 1193-6; MJA 163 (1995), 483-5.

Pesticides are discussed in the Environment section. On the dangers of chemicals in the developing world due to ignorance, NS (9 Dec 1995), 8. There is likely to be a world-wide ban against persistent chemicals, NS (11 Nov 1995), 7. A new International Society of Cancer Chemoprevention has been founded, Lancet 346 (1995), 1222. Occupational injuries, illness affect 1 in 13 Canadians, CMAJ 153 (1995), 1782-3.

Letters on alcohol consumption and female mortality, NEJM 333 (1995), 1081-2. Alcohol is considered a threat to young persons equal to drugs, BMJ 311 (1995), 1388.

On nicotine addiction, NEJM 333 (1995), 1196-1203, 1225-6; JAMA 274 (1995), 1347-52, 1353-8, 1390-1; BMJ 311 (1995), 1250; Science 270 (1995), 573-4. The Wall Street Journal has charged that a US company uses additives in cigarettes, Lancet 346 (1995), 1151. BAT industries increased profits by 34% in 1995 due to increased sales in poorer countries, BMJ 311 (1995), 1321; and on mortality, BMJ 311 (1995), 1530-3. The US government has continued support of tobacco exports, Nature Medicine 1 (1995), 989-90. Sales in Japan continue to increase mortality due to lung cancer, Economist (4 Nov 1995); links seen everywhere also, NZMJ 108 (12995), 419-20. In New Zealand between 1976 and 1991 the prevalence of cigarette smoking in adults decreased from 36 to 26%, NZ Public Health Report 2 (1995), 89-91. On dangers of passive smoking in children, BMJ 311 (1995), 1152-4, 1164; Science 270 (1995), 903. In New Zealand a divorced father has been denied access by a court to children if he smokes in their presence. A sociological study of UK middle class smoking and drinking is Sociology of Health & Illness 17 (1995), 668-80. Cessation of smoking may result in slight increase in overweight persons, NEJM 333 (1995), 1165-70, 1214-6.

Tightened controls on boxing have been made in the UK, and the government is reluctant to ban it, BMJ 311 (1995), 1183. A study in young monkeys suggests that the wearing of spectacles in young children may alter eye development, Nature Medicine 1 (1995), 737-9, 761-6.

A call for daytime running lights to be mandatory, as is already done in 7 countries, is made in Public Health Reports 110 (1995), 233-9. Airbags have saved many lives already and will become mandatory in new cars in some countries, however there have been several child deaths which suggests further improvements are needed, JAMA 274 (1995), 1752-3. A study has found increased mortality among Dutch development workers, especially traffic accidents, BMJ 311 (1995), 1343-4. A study showing that anticipation of job loss affects health even before change in employment, Ferrie, J.E. et al. "Health effects of anticipation of job change and non-employment: longitudinal data from the Whitehall II study", BMJ 311 (1995), 1264-9.

Computer based prescribing is recommended in BMJ 311 (1995), 1181-2; and on drug errors, BMJ 311 (1995), 1367-8. Patients given LSD in the UK in the late 1950s have won legal aid to seek compensation, BMJ 311 (1995), 1185-6. A call to deglamorise cannabis is made in Lancet 346 (1995), 1241. A vaccine against cocaine is reported in Nature 378 (1995), 666-7, 727-30.

A paper reporting the cloning of the obese gene, ob, and the demonstration that it encodes a secreted protein (leptin) that binds specifically to a receptor (OB-R) in the brain, have shown that it is the same as the diabetes gene, Science 271 (1996), 994-99, see also 913. The most potent regulator of feeding yet found is glucagon-like peptide-1 has been found, Lancet 347 (1996), 47; as report last time, Nature 379 (1996), 6-72; and on leptin, NEJM 334 (1996), 292-5, 324-5. Weight loss is better than exercise to reduce risk of heart attack, JAMA 274 (1995), 1915-21, 1964-5.

Mid-life systolic blood pressure is a predictor of reduced cognitive function in later life, JAMA 275 (1996), 1846-51. On cholesterol, Science 271 (1996), 460-1; Lancet 346 (1995), 1647-53. Advice not to generally take lipid-lowering drugs because of possible carcinogenicity is JAMA 275 (1996), 55-60, 67-9. A review of the US diet and recommendations for improvement is AJPH 85 (1995), 1609-10, 1623-9. A US study has found no evidence of a link between breast cancer and higher dietary fat intake, NEJM 334 (1996), 356-61; nor is there is evidence of weight gain with hormone replacement therapy, JAMA 275 (1996), 46-9. Beta-carotene has been reported to have mortality, causing cessation of some cancer trials in the USA, Lancet 347 (1996), 249. The benefits of exercise encourage work on education at school level, BMJ 312 (1996), 199.

On December 21, 1995 the Supreme Court of Canada dismissed an appeal by Dow Corning Corporation against a lower court finding of negligence in the manufacture of a breast implant. The plaintiff, had undergone breast implant surgery in 1983. In 1985 the right implant had to be removed because it had ruptured. In 1989 she sued Dow and the doctor who had performed the initial surgery. The Supreme Court stated that "The principles underlying the doctrine of 'informed consent' apply to the relationship between manufacturers of medical products and consumers. The manufacturer-consumer relationship, unlike the doctor- patient relationship, is characterized primarily by a lack of direct communication which creates a relationship of complete dependency between manufacturer and patient. Manufacturers, therefore, can be reasonably required to make clear, complete and current informational disclosure to consumers concerning the risks inherent in the ordinary use of their products." According to the "learned intermediary" rule a manufacturer of medical devices may discharge this duty of disclosure by informing doctors of the risks associated with the use of the product. The doctor will in turn inform the patient. However, in this case Dow's warning to the surgeon was inadequate, and so the judgment against the company will stand, Canadian Bioethics Report (Jan 1996). See a letter on another disease, JAMA 275 (1996), 184-5.

A link has been made showing the level of the B form of monoamine oxidase is reduced in people who smoke by about 40%, which in turn increases the addictive nature of smoking, Nature 379 (1996), 677-8. Smoking in Canada is discussed in CMAJ 154 (1996),159+, 191-2, 226-32. Some affect is being seen from the tough smoking law in Ontario. On tobacco advertising bans in the UK, IDHL 46 (1995), 575. Thailand is requiring a list of additives to be shown on the tobacco, something other countries could also do, Lancet 347 (1996), 112. There are also tobacco wars in China, Lancet 346 (1995), 1695. The link between smoking and increased heart attacks is explained in Wang, XL et al. "A smoking-dependent risk of coronary artery disease associated with a polymorphism of the endothelial nitric oxide synthase gene", Nature Medicine 2 (1996), 41-5. Another health effect is also observed in passive smokers, NEJM 334 (1996), 150-4. A call for inclusion of tobacco related disease in the list of diseases is renewed in JAMA 275 (1996), 276-80; and on publishing research sponsored by the tobacco industry, BMJ 312 (1996), 133-4.

A review of addiction is Lancet 347 (1996), 162-6; and the question of legal regulation is in Lancet 347 (1996), 301-5. Letters on decriminalization of cannabis are in Lancet 347 (1996), 1708-10. A criticism of the British government's decision to increase recommended drinking allowances is Lancet 347 (1996), 1643-4.

A FDA committee has recommended calcium-blockers are safe, Lancet 347 (1996), 313. On the ethics of drug testing, NEJM 334 (1996), 126. Thompson NP "Genetics versus environment in inflammatory bowel disease: results of a British twin study", BMJ 312 (1996), 95-6. On general environmental and genetic links, BMJ 312 (1996), 271. On general public health, Lancet 346 (1995), 1545-6; 347 (1996), 3-4; NEJM 334 (1996), 203-7. More victims of Minamata disease in Japan have been given compensation, Lancet 346 (1995), 1695-6.

The health dangers of EMF radiation are discussed in NS (17 Feb 1996), 4; Nature Medicine 2 (1996), 23-4; Nature 379 (1996), 571; BMJ 312 (1996), 463. The health dangers of nuclear radiation are reviewed in NEJM 333 (1995), 1787-8; JAMA 275 (1996), 72-3; JMG 32 (1995), 997; and on medical X-rays, Lancet 346 (1995), 1701-2. In Japan there is much public distrust of nuclear power (see also the paper by Macer et al. in this issue (March 1996) and in D. Macer, Bioethics for the People by the People (1994). This has grown with a sodium coolant leak in Monju fast breeder reactor, which was still in a test phase of development, Nature 379 (1996), 196.

The UK Ministry of Defense has ordered a new study into Gulf War syndrome, Nature 379 (1996), 482. A report from experiences during the Great Hanshin earthquake of 1995 is Lancet 347 (1996), 307. In the USA, the National Highway System Designation Act was passed which included removing the 55 miles per hour national maximum speed limit, which will result in increased traffic deaths, Lancet 347 (1996), 1547.

There is increasing use of behaviour pills in US schools, NS (9 March 1996), 7. A letter on effects of sugar on children's behaviour is JAMA 275 (1996), 756-7; and on antisocial behaviour, JAMA 275 (1996), 403-4.

A US study of 43757 health care professionals between 40-75 years of age has found fiber intake reduces heart disease, Rimm, EB et al. "Vegetable, fruit, and cereal fiber intake and risk of coronary heart disease among men", JAMA 275 (1996), 447-51, 486-7. Coffee is not linked to heart disease in women, JAMA 275 (1996), 458-62. Research on obesity is reviewed in Biotechnology 13 (1995), 1060-3. WHO is launching a campaign against obesity, Lancet 347 (1996), 751; and on health effects, NEJM 334 (1996), 732-3; AJPH 86 (1996), 25-30. A study finding vitamin E may decrease risk and beta-carotene may increase risk of angina is JAMA 275 (1996), 693-8; and a study showing beneficial effects of vitamin E from the Cambridge Heart Antioxidant Study is Lancet 347 (1996), 776-7, 781-6. Personality is also linked to heart disease, Lancet 347 (1996), 417-21; AJPH 86 (1996), 301-3. Consumption of oily fish may protect against asthma, MJA 164 (1996), 137-40; and on diet, BMJ 312 (1996), 931-40.

Silicone breast implants are discussed in SA (April 1996), 36-7; and a study of health care professionals confirms some health effects, JAMA 275 (1996), 616-21, 680; BMJ 312 (1996), 595. An Australian study finds people spend twice as much on alternative medicines as they do on contributions to pharmaceuticals, Lancet 347 (1996), 569-73, 972-3; and on profits from nutriceuticals, Lancet 347 (1996), 775. A study finding religious belief is positive for health is Kark, JD. et al. "Does religious observance promote health? Morality in secular vs. religious Kibbutzim in Israel", AJPH 86 (1996), 341-6.

On March 13 the history of US smoking court cases was changed when the Liggett Group, the 5th largest tobacco company in the USA, agreed to settle a court case out of court and pay for prevention programs and pay funds to states for health damage, Lancet 347 (1996), 823. Also, NS (30 March 1996), 10; AJLM XXI (4, 1995), 445-72. Passive smoking is discussed in JAMA 275 (1996), 441-2; MJA 164 (1996), 260-1, 266-9; BMJ 312 (1996), 997-8, 1051-2. Dangers of maternal smoking and congenital urinary tract anomalies are confirmed, AJPH 86 (1996), 249-53. There is controversy in Cambridge over the funding of a professorship by BAT industries (a tobacco company), BMJ 312 (1996), 721-2, 773-4; see also a series of papers in Science 272 (1996), 488-94. People may misunderstand current tar values on cigarettes, AJPH 86 (1996), 18-24, 231-6. A study of the length of time adolescent smokers use cigarettes is in AJPH 86 (1996), 156-8, 214-20, 253-6; also p.221-4. Dopamine may reinforce smoking addiction, BMJ 312 (1996), 529.

Confirmation of the role of mild alcohol use in reducing heart disease is BMJ 312 (1996), 731-6, 736-41; and on alcoholism, JAMA 275 (1996), 803-4; Lancet 347 (1996), 545-6; MJA 164 (1996), 133-4, 141-5. There will be stricter control on soft drugs in the Netherlands, Lancet 347 (1996), 895; to control harder drugs, also see BMJ 312 (1996), 635-7. Heavy marijuana use appears to impair brain function, JAMA 275 (1996), 521-7, 560-1. Drug testing is being made tougher in the 1996 Olympic Games, but it is still difficult to detect all, JAMA 275 (1996), 348-50.

Book reviews on the health effects of radiation are NEJM 334 (1996), 544-5; Lancet 347 (1996), 525-6; Science 271 (1996), 1821-2; and of health and nuclear weapons, JAMA 275 (1996), 808-9; Science 271 (1996), 1664. The efforts to attempt a nuclear test ban treaty are discussed in NS (9 March 1996), 6. A review of the ten year's since Chernobyl is SA (April 1996), 44-9; NS (20 April 1996), 40-3; Science 272 (1996), 352-60; BMJ 312 (1996), 1052-3. Floods in Chernobyl have threatened millions of people from radiation, NS (23 March 1996), 4. Also fish in the North Atlantic could be threatened by past radioactive dumping by Russia, NS (2 March 1996), 7. On Seascale cancer cluster, BMJ 312 (1996), 865. Some medical isotopes may be misused, Science 271 (1996), 1221.

On regulation of Euromedicines, Lancet 347 (1996), 483. Over-the-counter drugs and the social effects are discussed in BMJ 312 (1996), 629-32, 644, 688-91, 758-60.

An ethical debate on the law is Unwin, NC. "Cycle helmets - when is legislation justified?", JME 22 (1996), 41-5. On the use of airbags, Lancet 347 (1996), 560; and seatbelts, AJPH 86 (1996), 31-4. Reviews of triage are in NEJM 334 (1996), 438-44, 460-1.

A study in the UK found women in houses with gas cookers have more respiratory problems, Lancet 347 (1996), 426-31. Asbestos and the amphibole hypothesis is discussed in AJPH 86 (1996), 179-86 The future of dental care is discussed in Nature Medicine 2 (1996), 283.

An English summary of the Health Council of the Netherlands April 1995 report on environmental risk assessment is Network 10 (March 1996), 26-8; (June 1996), 8-9; and of toxic substances levels in the workplace, Network 10 (March 1996), 28-32. A special issue of The Science of the Total Environment 184 (1996), 1-147 is on "Ethical and philosophical issues in environmental epidemiology", from a 1994 WHO/ISEE international workshop. A review of this volume is expected in the next issue of EJAIB. The National Research Council of the USA is supporting a new approach to assessment, Nature 381 (1996), 638, 659; Lancet 347 (1996), 1179; EST 30 (1996), 238-9A; and a review is Perera, F. "Uncovering new clues to cancer risk", SA (May 1996), 54-62. Air pollution in homes may be more important than outdoor pollution but is difficult to monitor, BMJ 312 (1996), 1316.

On antioxidants such as carotene and cancer risk, studies have found no benefits!, NEJM 334 (1996), 1145-9, 1150-5, 1189-90. Letters on the link between dietary fat and breast cancer are in NEJM 334 (1996), 1606-7; Lancet 347 (1996), 1346, 1351-6. Calls for reducing salt are made in BMJ 312 (1996), 1239-41, 1287-9. A series of papers on heart attacks are in Science 272 (3 May 1996), 629+. Nonsteriodal anti-inflammatory drugs and estrogen reduce risk of Alzheimer's risk, JAMA 275 (1996), 1389-90. There is much debate over melatonin and health, BMJ 312 (1996), 1242-3. Herbal medicines may do more harm then good sometimes, Newsweek (13 May 1996), 44-54. Obesity gene is discussed in MJA 164 (1996), 393-4; also Science 272 (1996), 959. In the USA, Dexfenfluraine (Redux) is the first obesity pill to be approved for 20 years, Lancet 347 (1996), 1321.

EMF fields and cancer are debated in Goldsmith, JR. "Epidemiological studies of radio-frequency radiation: current status and areas of concern", Science of the Total Environment 180 (1996), 3-8; Lancet 347 (1996), 1059-60.

Papers discussing the health effects of Chernobyl include: Nature 380 (1996), 653, 658, 665-6; Dubrova YE et al. "Human minisatellite mutation rate after the Chernobyl accident", Nature 380 (1996), 683-6; Baker, RJ et al. "High levels of genetic change in rodents of Chernobyl", Nature 380 (1996), 707-8; NS (27 April 1996), 6; BMJ 312 (1996), 1119; Lancet 347 (1996), 1176, 1178, 1482-3; Science 272 (1996), 935-6. The mutation rate in children doubled. In the study of voles living next to the reactor, every individual had a different DNA sequence at the gene studied, mitochondrial cytochrome b, which is unprecedented DNA diversity. The base-pair substitution rates of 1 in 10,000 per generation are the highest known, yet the vole population remains healthy. On nuclear power protests, NS (18 May 1996), 3; (15 June 1996), 6; Nature 381 (1996), 199-200; and on cleaning up Hanford in the USA, SA (May 1996), 88-97; and storage of waste at Yucca mountain, SA (June 1996), 72-9. Natural radiation may account for 3% of deaths in the UK according to research on low level gamma radiation, NS (4 May 1996), 4. There are claims of radiation safety breaches at CERN in France, Science 272 (1996), 655.

A recommended vitamin C dose of no more than 400mg is suggested by the kinetics in volunteers, and a safe dose is less than 1000mg a day, PNAS 93 (1996), 3704-9. The benefits of moderate alcohol consumption are raised in BMJ 312 (1996), 1179-80. There are still dangers driving under the influence and Europe is working on an action plan, Lancet 347 (1996), 985-6.

Positive results of hospital smoking bans have been found in the USA, JAMA 275 (1996), 1252-7, 1281-4. There is still widespread residual serum traces of tobacco in most of the population, JAMA 275 (1996), 1233-40. Also on tobacco, JAMA 275 (1996), 1217-9, 1285, 1301; Lancet 347 (1996), 1476, 1546; Science 272 (1996), 1247. A new low smoke cigarette is being marketed by Reynolds as one which does not annoy non-smokers, NS (11 May 1996), 11. A Danish study finding smoking is the major cause for differences in lung cancer incidence, BMJ 312 (1996), 1259-63. The Netherlands has proposed new anti-smoking laws, BMJ 312 (1996), 1440.

A series of papers on inappropriate distribution of medicines by professionals in developing countries is SSM 42 (1996), 1117-1200+ (No. 8), a problem not limited to there. On FDA drug approvals, Nature Biotechnology 14 (April 1996), editorial, 511-2. Different drugs can also have different names in different countries which is confusing to patients, BMJ 312 (1996), 1315-6. A review of taxoids for use against cancer is SA (June 1996), 94-8. More mechanisms by which cocaine interferes with the brain has been found, Science 272 (1996), 957.

On breast implants, Angell, M. "Evaluating the health risks of breast implants: The interplay of medical science, the law and public opinion", NEJM 334 (1996), 1513+. France has extended its moratorium, Lancet 347 (1996), 1543 Subclinical neurological damage of organophosphate pesticides has been found in BMJ 312 (1996), 1312-3. Du Pont may face compensation claims from 40 British families whose children were born without eyes depending on the results of a Florida trial of benomyl, a pesticide, BMJ 312 (1996), 1247. Pesticides may link with estrogen to develop breast cancer, EST 30 (1996), 210-1A. Dangers of lead are discussed in MJA 164 (1996), 390-1. Exposure to environmental lead during the first seven years of life is associated with cognitive deficits that seem to persist into later childhood; Tong, S. et al. Lifetime exposure to environmental lead and children's intelligence at 11-13 years: the Port Pirie cohort study, BMJ 312 (1996), 1569-75. On mercury EST 30 (1996), 193A.

A study on the role of age in sun cancer avoidance is Carmel, S. et al. "The role of age and an expanded health belief model in predicting skin cancer protective behavior", Health Education Research 9 (1994), 433-47. A year study found no link between arthritis pain and the weather, PNAS 93 (1996), 2895-6. There are numerous comments on tougher gun laws in Australia, including BMJ 312 (1996), 1378; Lancet 347 (1996), 1616; also, CMAJ 154 (1996), 1619.

A new neuropeptide Y receptor involved in obesity has been found, Gerald, C. et al. "A receptor subtype involved in neuropeptide-Y-induced food intake", Nature 382 (1996), 168-71; GEN (August 1996), 1, 8. It is the most potent appetite stimulator so far described. The role of leptin is discussed in Nature Medicine 2 (1996), 723-4; PNAS 93 (1996), 5793-6, 6221-4, 6231-5. Also on obesity, SA (August 1996), 88-94; JAMA 276 (1996), 445; Lancet 347 (1996), 1756; AJPH 86 (1996), 798-803. Dietary fat and risk of coronary heart disease in men is studied in BMJ 313 (1996), 84-90. On calcium channel blockers and safety, Lancet 348 (1996), 488-9. On adverse effects of salt, Lancet 348 (1996), 250-1; and positive effects of vitamin E, Lancet 347 (1996), 1689-91. Garlic eaten raw is perhaps the best of easily acceptable foods that improves heart condition.

Herbal medicine research from Chinese medicine is discussed in GEN (15 June), 29, 32; (August 1996), 10, 35; NS (13 July 1996), 12-3; Lancet 348 (1996), 5-6; Science 273 (1996), 578. Too much fibre may damage health, Lancet 348 (1996), 319-20. The USA is relaxing the Delaney clause, so that foods can contain carcinogens if they pose a negligible risk, NS (27 July 1996), 9.

Cigarette advertising and onset of smoking in children is studied in BMJ 313 (1996), 398-9, 400-1. Also on smoking, BMJ 313 (1996), 96. Methods to stop smoking are discussed in JAMA 275 (1996), 1882-3, 276 (1996), 371-2. Although we will enter the 21st century with 3 fewer diseases than 100 years ago, smallpox, Guinea worm disease and polio, but tobacco is predicted to triple its annual death toll over the next 3 decades, JAMA 275 (1996), 1846-7. On tobacco companies, AJPH 86 (1996), 1073-5; NS (24 August 1996), 6. Massachusetts has had success in reducing alcohol-impaired driving, AJPH 86 (1996), 791-7. On addiction, Science 273 (1996), 611-2; Pontieri, FE et al. "Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs", Nature 382 (1996), 255-7, 206-7.

A review of the mechanism that sunlight can cause skin cancer is in SA (July 1996), 52-9. In France patient groups have accused the government of delaying for years the removal of asbestos from buildings, Lancet 348 (1996), 53. On environmental knowledge, Hearne, SA. "Tracking toxics. Chemical use and the use of the public's right to know", Environment 38 (July/August 1996), 4-9, 28-34. EPA reassessment has found there maybe 20 times less cancer risk from PCBs as was first thought, EST 30 (1996), 332-3A. A review of occupational medicine is JAMA 275 (1996), 1831-2. The question why developing countries are slow to remove lead from petrol is discussed in NS (27 July 1996), 12-3.

Anabolic steroid abuse by body builders is associated with male subfertility, BMJ 313 (1996), 100. On the use of drugs and ethics, Catlin, DH & Murray, TH. "Performance-enhancing drugs, fair competition, and Olympic sport", JAMA 276 (1996), 231-7. On the dangers of sport, Lancet 348 (1996), 277; NEJM 335 (1996), 281-3. Papers on the links between availability of guns and violence are in Blendon RJ et al. "The American public and the gun control debate", JAMA 275 (1996), 1719-22, 1723-4, 1729-33, 1765-7; yet still some people promote guns, Lancet 348 (1996), 52. Australia has passed tighter laws on gun control, Lancet 348 (1996), 327. One risk factor for hospitalization for injury is prior injury, AJPH 86 (1996), 929-34.

The dangers of ionizing radiation to diagnosis are discussed in MJA 165 (1996), 743-7. A commentary on the mysteries of childhood leukaemia are in Nature 382 (1996), 303-4. Letters on breast cancer among radiologic technologists are in JAMA 276 (1996), 369-70. On the health effects in survivors of Chernobyl see letters in JAMA 275 (1996), 1881-2; Science 273 (1996), 313, 562-4. The USA and Belarus have began building a power plant to burn contaminated forest trees from Chernobyl, Science 273 (1996), 37. The US-Japan long term study on health effects of atomic bomb survivors has been given more secure funding, Science 273 (1996), 171. Bacteria may pose some concerns about safety of long term radiation storage, NS (7 Sept 1996), 12. A report on the Canberra Commission on the Elimination of Nuclear Weapons is NS (24 August 1996), 7.

Analysis of why stress is bad for our brains is Science 273 (1996), 749-50. A review of psychiatric drug development in Japan is in Science 273 (1996), 318-9. A survey in Australia has found many laboratories have high error rates, MJA 165 (1996), 128-30. Letters on breast implants and connective tissue disease are in JAMA 276 (1996), 101-3; and a book review in Science 273 (1996), 917.

A study concluding that typical residential magnetic fields generated by high voltage power lines do not seem to be related to the risk of overall cancer in adults. A study of 383,700 people who lived during 1970-89 within 500 metres of overhead power lines of 110-400kV in a magnetic field calculated to be greater than or equal to 0.01 micro T, found 8,415 cases of cancer; Verkasalo, PK et al. "Magnetic fields of high voltage power lines and risk of cancer in Finnish adults: nationwide cohort study", BMJ 313 (1996), 1047-50. All incidence rate ratios for both sexes combined were non-significant and between 0.91 and 1.11. Significant excesses were observed in multiple myeloma in men (incidence rate ratio 1.22) and in colon cancer in women (1.16). The previously suggested associations between extremely low frequency magnetic fields and tumours of the nervous system, lymphoma, and leukaemia in adults and breast cancer in women were not confirmed. A letter on leukemia in Japan is Lancet 348 (1996), 821-2.

Letters that do not conclude there is a higher mutation rate in children exposed to nuclear bomb blasts in Japan or Chernobyl accident, are in Nature 383 (1996), 226; and on a letter opened to the public that was a British study criticizing the US researchers in Japan after the bombs because they failed to note the residual radiation effects, Lancet 348 (1996), 620. See also Lancet 348 (1996), 748; Science 273 (1996), 1787. On the nuclear weapons test ban, NS (28 Sept. 1996), 59.

Studies on women and men showing that cigarette smoking is an independent and avoidable risk factor for Age-Related Macular Degeneration are JAMA 276 (1996), 1141-1146; 1147-1151. On the blindness risk with smoking, BMJ 313 (1996), 898. On the dangers, Phillips, AN et al. "Life expectancy in men who have never smoked and those who have smoked continuously: 15 year follow up of large cohort of middle aged British men", BMJ 313 (1996), 907-8. When study estimates were combined with those from national mortality statistics for men aged 20-40, only an estimated 42% (95% confidence interval 36% to 50%)of lifelong smokers alive at the age of 20 would be alive at 73, compared with 78% (74% to 82%) of lifelong non-smokers. A book review of Smoke Screen: Women's Smoking And Social Control is BMJ 313 (1996), 1018. Passive smoking is discussed in BMJ 313 (1996), 929-933; AJPH 86 (1996), 1267-72, 1303-5; JAMA 276 (1996), 595, 603-4; and non-smoking spouses of smokers have more coronary heart disease due to the smoke, Lancet 348 (1996), 673; Circulation 94 (1996), 622-8. Smoke slows down the development of children's lungs, NEJM 335 (1996), 931-7. A report of the FDA regulation of tobacco products since 23 August is NEJM 335 (1996), 988-94. On seeking smoke-free workplaces, JAMA 276 (1996), 909-13; and on book reviews, NEJM 335 (1996), 981-2. On brain effects of nicotine, Nature 383 (1996), 670-1.

Mutational hotspots in P53 gene have been found for cigarette components, Denissenko, MF. et al. "Preferential Formation of Benzo[a]pyrene Adducts at Lung Cancer Mutational Hotspots in P53", Science 274 (1996), 430-2. The distribution of benzo[a]pyrene diol epoxide (BPDE) adducts along exons of the P53 gene in BPDE-treated HeLa cells and bronchial epithelial cells was mapped at nucleotide resolution. Strong and selective adduct formation occurred at guanine positions in codons 157,248, and 273. These same positions are the major mutational hotspots in human lung cancers. Thus, targeted adduct formation rather than phenotypic selection appears to shape the P53 mutational spectrum in lung cancer. These results provide a direct etiological link between a defined chemical carcinogen and human cancer. A study of lung damage by particulate air pollution has found more ozone increases the damage, EST 30 (1996), 382A. A study of the types of p53 mutations in murine skin cancers induced by PUVA therapy (includes UV light) is PNAS 93 (1996), 7961-5.

Leptin in obesity is discussed in BMJ 313 (1996), 953-4. Paul Zimmet et al. "Serum leptin concentration, obesity, and insulin resistance in Western Samoans: cross sectional study", BMJ 313 (1996), 965-8. They conclude the strong relation of leptin with obesity is consistent with leptin production being proportional to mass of adipose tissue. The relation with insulin independent of body mass index suggests a possible role for leptin in insulin resistance or hyperinsulinaemia

A call for healthy diets and to enjoy your fruits and vegetables is in Key TJA et al. "Dietary habits and mortality in 11000 vegetarians and health conscious people: results of a 17 year follow up", BMJ 313 (1996), 775-8; 765-6. In this cohort of health conscious individuals, daily consumption of fresh fruit is associated with a reduced mortality from ischaemic heart disease, cerebrovascular disease, and all causes combined. The incidence of high cholesterol has fallen with changed cooking oil in Mauritius, BMJ 313 (1996), 1044-6; and on a study of fish eaters in Tanzania, Lancet 348 (1996), 784-8. Also on diets and disease, Lancet 348 (1996), 670, 834, 904-6, 956-9; NEJM 335 (1996), 716-20, 738-9, 1065-9; JAMA 276 (1996), 647-8, 875-81. 882-8, 914-5; Nature 383 (1996), 589-90.

Pesticides have been linked to Gulf war syndrome, BMJ 313 (1996), 897; as have chemical weapons exposure from exploding ammunition dumps in Iraq. Exposure to 2,4-D and MCPA herbicides in farmers has a short term immuno-suppressive activity, Occupational & Environmental Medicine 53 (1996), 583-5. Methods for global tracking of persistent organic pollutants are reviewed in EST 30 (1996), 390-6. On the dangers of infected water, AJPH 86 (1996), 1203-4. On the removal of the Delaney clause in the USA, Nature Biotechnology 14 (1996), 1056; EST 30 (1996), 380A. A review of the dangers of cadmium exposure to health is Ambio 25 (1996), 370-6.

A code of ethics for Organizations is in , J. Occupational & Environmental Medicine 38 (1996), 869-83. Certain workers have a higher rate of germ cell testicular cancer, seminoma for miners and food and beverage processors, and utilities employees, while leather industry employees have more nonseminoma, in an Ontario study, J. Occupational & Environmental Medicine 38 (1996), 884+.

Hormone Replacement Therapy may increase bone density. A retrospective study of 13 women runners shows that a combination of estrogen and progestin significantly increased bone density among women getting hormone replacement therapy, Arch Internal Med. 156 (1996), 2193-2195. A letter on breast cancer and hormone exposure is Lancet 348 (1996), 682-4. Letters on evaluating the health risks of breast implants are in NEJM 335 (1996), 1154-6.

A UK survey (N=2000) is Priest, RG et al. "Lay people's attitudes to treatment of depression: result of opinion poll for Defeat Depression Campaign just before its launch", BMJ 313 (1996), 858-60. The lay public in general seemed to be sympathetic to those with depression but reluctant to consult. Most (1704 (85%)) believed counseling to be effective but were against antidepressants as addictive. They concluded, although people are sympathetic towards those with depression, they may project their prejudices about depression and the rationale for antidepressant treatment. Age differences in depression in Japan are reported in SSM 43 (1996), 967-74.

On morals and public health, Lancet 348 (1996), 618-9. Secrecy in drug safety can destroy trust, according to a critical report in the UK, NS (28 Sept. 1996), 4; Lancet 348 (1996), 765. In general on public health, JAMA 276 (1996), 923-4; NS (14 Sept. 1996), 3-4. Getting guns out of society and homes is discussed in BMJ 313 (1996), 739-40, 1030-1. A commentary on responses to disasters is AJPH 86 (1996), 1207-10. A paper showing that lowering US state legal blood alcohol limits to 0.08% would result in a reduction by 500-600 in the fatal crashes each year, AJPH 86 (1996), 1297-9. A survey of UK university student alcohol use is Lancet 348 (1996), 922-5.

A report released at the end of 1996 by the US National Research Council, Possible Health Effects of Exposure to Residential Electric and Magnetic Fields, Washington, DC: National Academy Press; 1996 (US$45), says, there remains unexplained a "weak but statistically significant" association between high levels of exposure to EMF and childhood leukemia--the observation made 20 years ago that triggered public concern over the issue (Am J Epidemiol. 1979; 1209: 273-284); Science 274 (1996), 910. The committee reviewed more than 500 reports of exposure to EMF; these reports investigated both electric fields, which are produced by any electrically charged particle, and magnetic fields, which occur when electrically charged particles are moving. The committee evaluated the epidemiologic evidence, experimental animal data, and in vitro data contained in the reports. "Over the years, a number of epidemiologists have found that children who live near concentrations of electric power lines are about 1.5 times more likely to contract leukemia [than those who live elsewhere]. The council report states that animal and laboratory studies of cells and tissues showed no discernible effects from exposure to EMF at intensities similar to those found in homes (50 Hz to 60 Hz). Only at extremely high field intensities, thousands of times higher than those found in homes, do cells react. In the USA, a major program of EMF investigations called Research and Public Information Dissemination (RAPID) is currently under way. It has about $65 million in funding from the US Department of Energy, National Institute of Environmental Health Sciences, and industry.

A legal court case is underway in the USA following claims of experiments on the corpses of those who died who had been involved in radiation experiments, NS (2 Nov 1996), 10. There are also claims in the UK that the government continues to hide experiments there, NS (30 Nov 1996), 3. Chernobyl forests that were contaminated are going to be burnt to generate electric power. About a quarter of the country of Belarus is contaminated, NS (26 Oct 1996), 9. However it may take 70 years to make the reactor area safe by sealing the reactor, and extracting radioactive fuel. France has started to demolish its facilities on Mururoa, NS (26 Oct 1996), 7. The US has approved salt bed burial of nuclear waste in New Mexico, Nature 383 (1996), 752; whereas Russia continues to pump waste into the ground, SA (Dec 1996), 20, 24. Yucca mountain repository is still expected to be the largest in the USA, Science 273 (1996), 913-4.

There have been direct links established between benzopyrene, a carcinogen in cigarette smoke, and p53 gene mutations, Lancet 348 (1996), 1157; Science 274 (1996), 430-2. Letters on nicotine and addiction are in Nature 383 (1996), 18-9; and alcohol makes the addictive crave for nicotine stronger, NS (23 Nov 1996), 18. Heavy smokers are recommended to avoid high dose beta-carotene supplements, Lancet 348 (1996), 1369. Canada is introducing tough laws on smoking advertisements, NS (14 Dec 1996), 3-4; Ontario already had some guidelines, as did other provinces, Health Law Journal 4 (1996), 221-58. On the FDA campaign to stop children smoking, FDA Consumer (Oct 1996), 7.

The receptor for morphine has been shown to be the u-opioid receptor, Nature 383 (1996), 759-60, 819-23; as may be the cocaine receptor, Zubieta, JK. et al. "Increased mu opioid receptor binding detected by PET in cocaine-dependent men is associated with cocaine-craving", Nature Medicine 2 (1996), 1225-9. There are differences between men and women, Nature Medicine 2 (1996), 1184-5, 1248-50. California and Arizona voted to approve marijuana therapy for pain relief, Nature 384 (1996), 95. A study of alcohol and drug use among US welfare recipients is AJPH 86 (1996), 1450-4.

A study of 5645 men in the west of Scotland found status for behavioural risk factors (exercise and smoking) was associated primarily with current socioeconomic circumstances, while status for physiological risk factors (serum cholesterol, blood pressure, body mass index, and FEV 1) was associated to varying extents with both past and present socioeconomic circumstances; Blane, D. et al. "Association of cardiovascular disease risk factors with socioeconomic position during childhood and during adulthood", BMJ 313 (1996), 1438+. Studies on health effects of garlic are still in dispute, see Lancet 348 (1996), 1186-7.

A call for examination of how discrimination may affect health in racial differences in blood pressure is made in Krieger, N. & Sidney, S. "Racial discrimination and blood pressure: the CARDIA study of young black and white adults", AJPH 86 (1996), 1370-8. Also on race and health, AJPH 86 (1996), 1401-5; NEJM 335 (1996), 1545-51, 1552-8, 1597-9. There are also regional differences as well. There is also suspicion that endothelin levels may be higher in blacks with hypertension, Science 274 (1996), 725. A letter on risk factors for heart disease in Asian Indians is Lancet 348 (1996), 1241-2.

Claims of health foods need to be backed up by more data than in the past in several countries, in efforts to improve the way food is advertised, NS (2 Nov 1996), 12-3. Milk from cows fed on a diet enriched with corn oil could help people against cancer, NS (16 Nov 1996), 8, by boosting conjugated linoleic acid. A study of US public found that public health encouragements to alter diet to prevent cancer can work, AJPH 86 (1996), 1394-400; and lifestyle change may prevent cancer, Lancet 348 (1996), 1436. Japanese-American men in Hawaii who continue a Japanese style of life have decreased diabetes, Lancet 348 (1996), 1020. A survey of the number of food adverts on TV found Australia and the US were the highest, NS (30 Nov 1996), 8.

In a Baltimore study of iron-deficient adolescent girls who were not anemic, iron supplements increased verbal learning and memory, Lancet 348 (1996), 992-6. On osteoporosis, Lancet 348 (1996), 1019.

A survey of the results of an anthropological survey of India which found 49% of communities eat meat regularly, only 16% were strictly vegetarian, NS (26 Oct 1996), 39-42. The rates of depression have been found to vary widely between different countries, SA (Nov 1996), 24, 28. There are sex differences in the effects of stress on social preferences in prairie voles, PNAS 93 (1996), 11980-4. Former UK coal miners are taking British Coal to court over chest diseases, BMJ 313 (1996), 1163.

Daily consumption of five to six cups of strong cafetiere increases serum alanine aminotransferase concentration, and also raises low density lipoprotein cholesterol concentration and thus the risk of coronary heart disease, Urgert, R. et al. "Comparison of effect of cafetiere and filtered coffee on serum concentrations of liver aminotransferases and lipids: six month randomised controlled trial", BMJ 313 (1996), 1362-5.

A call for focusing on non-fatal diseases such as arthritis rather than only on fatal diseases, as a way to increasing quality of life of the elderly is shown in Boult, C. et al. "Decreasing disability in the 21st century: The future effects of controlling six fatal and nonfatal conditions", AJPH 86 (1996), 1388-93. Chronic diseases have high costs across all ages, JAMA 276 (1996), 1473-9. Two studies showing keeping pet birds does not increase risk of lung cancer are BMJ 313 (1996), 1233-5, 1236-8.

In a study of the marketing approval dates of 214 drugs introduced into the world market from Jan 1990 through Dec 1994, the US and the UK have similar patterns of drug availability, but the US has a number of therapies with significant public health benefits that are not yet available in the UK; David A. Kessler, et al. "Approval of New Drugs in the United States: Comparison With the United Kingdom, Germany, and Japan ",JAMA 276 (1996), 1826-31. The findings also show that the US approves drugs faster than Germany and Japan. Globalisation of food is leading to calls for international studies of foodborne illness, BMJ 313 (1996), 1093-4.

The case of an editor who was contacted by the makers of NutraSweet aspartame numerous times after they learnt of a forthcoming negative research paper is described in Lancet 348 (1996), 1435. Scientists are still debating the adrenal hormone DHEA which is supposed to be an anti-aging hormone, JAMA 276 (1996), 1365-7.

The US National Rifle Association may have been successful in stopping funding for the Centers for Disease Control research on the effects of guns on violence, Lancet 348 (1996), 1025. Efforts to ban boxing in the UK by the BMA are still to bring about a ban, BMJ 313 (1996), 1168. On dementia and driving, Lancet 348 (1996), 1114. A review of lessons from Kobe and open emergency communications is Science 273 (1996), 739-40.

A report from Health Council of the Netherlands, Marihuana as Medicine (1996, 21E) concludes that there is insufficient scientific evidence to warrant legalizing the use of marihuana as medicine, due to its side effects and alternatives. However there is debate in the USA still, Science 275 (1997), 485; NEJM 336 (1997), 366-7; BMJ 314 (1997), 92. A survey of illicit drug use in the USA by persons with disabilities is AJPH 86 (1996), 1613-5. On reassessment of thalidomide, NatMed 3 (1997), 8. A discussion of former FDA commissioner David Kessler is NatMed 3 (1997), 6-7; NatBio 15 (1997), 9.

Lead exposure may be linked to tooth decay, NS (18 Jan, 1997), 5. The potency of estrogenic pesticides is reviewed in Science 275 (1997), 405-6. Determination of platinum is described in EST 31 (1997), 309+. Canada and France differ on dangers of asbestos, Nature 385 (1997), 379.

A review of drug therapy is Landry, DW "Immunotherapy for cocaine addiction", SA (1997), 28-30. There are common neural substrates for the addictive properties of nicotine and cocaine, Science 275 (1997), 83-5. The matching of alcoholics with particular treatments is recommended in Science 275 (1997), 35. Alcohol-impaired driving was reported by 2.5% of US drivers in 1993, JAMA 277 (1997), 122-5. Moderate alcohol consumption has improved life expectancy in middle-aged Chinese men, BMJ 314 (1997), 18-23. It did not matter what type. Hangovers may be due to methanol, not ethanol, BMJ 314 (1997), 2-3. On alcohol and health, BMJ 314 (1997), 414-8, 420-4, 441.

Smoking, Kessler, DA. et al. " The Legal and Scientific Basis for FDA's Assertion of Jurisdiction Over cigarettes and Smokeless Tobacco", JAMA 277 (1997), 405-9. The FDA concluded that cigarettes and smokeless tobacco are subject to FDA jurisdiction because they contain a "drug," nicotine, and a "device" for delivering this drug to the body. On FDA Regulation of Tobacco Advertising and Youth Smoking, JAMA 277 (1997), 410-418. The use of tobacco by Indians in Northern Canada is high, CMAJ 156 (1997), 345-6. Also on smoking in Canada, CMAJ 156 (1997), 237-48; NatMed 3 (1997), 9. On litigation, Annas, GJ. "Tobacco litigation as cancer prevention: dealing with the devil", NEJM 334 (1997), 304-8. A lawsuit has begun in France, Newsweek (13 Jan 1997), 33; BMJ 314 (1997), 93. Brain monoamine oxidase is inhibited in smokers, PNAS 93 (1996), 14065-9. Nurses can help patients stop smoking, AJPH 86 (1996), 1557-60. Hong Kong University has declined tobacco money, BMJ 314 (1997), 169.

The reasons for a recent decline in mortality from coronary heart disease in the USA, 1980-1990, are reported in JAMA 277 (1997), 535-542. On the use of education as an indicator of socioeconomic position, AJPH 86 (1996), 1525-6. A survey of the costs of adverse drug events in hospitalized patients in the USA is JAMA 277 (1997), 307-11.

The USA and Russia are to study radiation effects on health, Science 275 (1997), 1062. Book reviews are in BMJ 314 (1997), 82-3. Chernobyl may not be shut down due to costs, NS (1 Feb), 18; (5 Feb, 1997), 4. On health near nuclear reprocessing plants, BMJ 314 (1997), 36-7, 101-6; NS (15 Feb, 1997), 3; (22 Feb), 5. Nuclear waste disposal (also see Environment section) is discussed in Nature 385 (1997), 282, 599; NS (11 Jan, 1997), 10.

Infrared imaging spectroscopy can be used to visualization of silicone gel in breast tissue, NatMed 3 (1997), 235-7. A federal judge in Oregon ruled at the end of Dec 1996 that the scientific evidence linking silicone breast implants to autoimmune disorders was too weak for a court case, Science 275 (1997), 21.

Letters calling for cyclists to wear helmets are in BMJ 314 (1997), 69-70. On the dangers of driving in Calcutta, NS (1 Feb. 1997), 51. On gun control, NEJM 336 (1997), 74-5. Car telephones increase the rate of vehicle crashes 4 times, Redelmeier, DA & Tishirani, RK. "Association between cellular telephone calls and motor vehicle collisions", NEJM 336 (1997), 453-8, 501-2.

In general a book review on public health is Nature 385 (1997), 594. Diabetes and hypertension in Britain's ethnic minorities is expected to have increased incidence of renal failure, calling for prevention, BMJ 314 (1997), 290-13. A review of the way parents protect children's health is EST 31 (1997), 63A.

Studies of alcohol consumption and health in the UK are in BMJ 314 (1997), 1159-1168. A possible link between milk and diabetes is being researched in New Zealand, though people are still urged to drink milk, BMJ 314 (1997), 836. Antioxidant state may be linked to heart disease, BMJ 314 (1997), 629-33. Fish consumption decreases death from heart disease, Daviglus, ML. et al. "Fish consumption and the 30 year risk of fatal myocardial infarction", NEJM 336 (1997), 1046-53. There has been a decline in heart attack mortality, JAMA 277 (1997), 535-42. A book review of Vitamania, is NEJM 336 (1997), 1112. A household food inventory is an easy method to measure food intake, AJPH 87 (1997), 272-5. Fruit and vegetables are recommended in FDA Consumer (March 1997), 16-23; JAMA 277 (1997), 871-2. Modest consumption of carbonated beverages does not appear to adversely affect mineral bone density in older women, AJPH 87 (1997), 276-9. High pressure processing is reviewed in NS (12 April 1997), 28-32.

There is debate over the way the EPA assesses the cancer risk from dioxin, EST 31 (1997), 130-1A; and the Californian Dept. of Health has been accused of delaying reports on it, Nature 386 (1997), 102. On methods to assess estrogens, a review is Zacharewski, T. "In vitro bioassays for assessing estrogenic substances", EST 31 (1997), 613-23. An Australian way to preserve grain without pesticides is NS (15 March 1997), 48. Studies of Gulf War syndrome are still being expanded, Lancet 349 (1997), 707, 931.

The cigarette group, Ligget, has admitted that cigarettes cause cancer and nicotine is addictive, and will pay a percentage of its earnings, Newsweek (31 March 1997), 44; Time (31 March 1997), 26-9; NS (29 March 1997), 3: Lancet 349 (1997), 932; JAMA 277 (1997), 751-3. Other tobacco companies are still denying it. On strategies to reduce child smoking, JAMA 277 (1997), 778. Maternal smoking is associated with significant expenses for children7s respiratory infections, AJPH 87 (1997), 205-9. A general explanation is Kessler, DA. et al. "The legal and scientific basis for FDA's assertion of jurisdiction over cigarettes and smokeless tobacco", JAMA 277 (1997), 405-9; and on advertising, Gostin, LO. et al. "FDA regulation of tobacco advertising and youth smoking", JAMA 277 (1997), 410-8. Hostility may affect health, and be related to smoking and alcohol, SSM 44 (1997), 1089-96. On industry sponsored research, Lancet 349 (1997), 588, 778. China has banned smoking on trains and buses, BMJ 314 (1997), 772. On methods to measure smoking, AJPH 87 (1997), 56-61, 108-111.

An NIH panel has concluded more study is needed to assess marijuana in medicine, JAMA 277 (1997), 867-8; Lancet 349 (1997), 624; NS (15 March 1997), 14-5. Letters on cocaine are in JAMA 277 (1997), 457-8. On herbal medicines, Lancet 349 (1997), 812; JAMA 277 (1997), 776. Fluoxetine is a contested drug for mental disorders, Lancet 349 (1997), 888. Drug treatments for dementia also raise ethical problems, BMJ 314 (1997), 693-4. Aspirin has been officially recognized as a preventative agent for heart attacks by the FDA, JAMA 277 (1997), 701. The transfer of drugs to developing countries is discussed in Hogerzeil, HV et al. "Guidelines for drug donations", BMJ 314 (1997), 737-40; and on some cases of false labels causing death, NS (29 March 1997), 16-7.

There have been a series of attempted cover-ups in the nuclear industry in Japan in March and April, which has decreased public confidence in the industry, especially in case of major leaks should they occur, Nature 386 (1997), 209. A tritium leak in the USA has shaken confidence also, Nature 386 (1997), 3; as has cancers from Three Mile accident, Lancet 349 (1997), 625; Environmental Health Perspectives 105 (1997), 52-7; and in the UK, Nature 386 (1997), 423; and in France, BMJ 314 (1997), 846. The US and Russia will study radiation effects together in Mayak, Science 275 (1997), 1062-3. There are numerous problems from the dumping of old nuclear submarines, SA (March 1997), 20-2. On the US nuclear clean-up, EST 31 (1997), 134-7A. A public survey is Feldman, DL & Hanahan, RA. "Public perceptions of a radioactively contaminated site: Concerns, remediation preferences, and desired involvement", Environmental Health Perspectives 104 (1996), 1344-52. A study that did not find association between EMF exposure and brain cancer is Occupational & Environmental Medicine 54 (1997), 7-13.

Breast implants are discussed in NEJM 336 (1997), 677-82, 718-9. Letters on whether bicycle helmets should be voluntary are in JAMA 277 (1997), 883-4; and on brain damage in divers, BMJ 314 (1997), 689-90. Owners of automatic guns in the USA also have a tendency for binge drinking, AJPH 87 (1997), 286-8.

Studies of alcohol consumption and health in the UK are in BMJ 314 (1997), 1159-1168. A possible link between milk and diabetes is being researched in New Zealand, though people are still urged to drink milk, BMJ 314 (1997), 836. Antioxidant state may be linked to heart disease, BMJ 314 (1997), 629-33. Fish consumption decreases death from heart disease, Daviglus, ML. et al. "Fish consumption and the 30 year risk of fatal myocardial infarction", NEJM 336 (1997), 1046-53. There has been a decline in heart attack mortality, JAMA 277 (1997), 535-42. A book review of Vitamania, is NEJM 336 (1997), 1112. A household food inventory is an easy method to measure food intake, AJPH 87 (1997), 272-5. Fruit and vegetables are recommended in FDA Consumer (March 1997), 16-23; JAMA 277 (1997), 871-2. Modest consumption of carbonated beverages does not appear to adversely affect mineral bone density in older women, AJPH 87 (1997), 276-9. High pressure processing is reviewed in NS (12 April 1997), 28-32.

There is debate over the way the EPA assesses the cancer risk from dioxin, EST 31 (1997), 130-1A; and the Californian Dept. of Health has been accused of delaying reports on it, Nature 386 (1997), 102. On methods to assess estrogens, a review is Zacharewski, T. "In vitro bioassays for assessing estrogenic substances", EST 31 (1997), 613-23. An Australian way to preserve grain without pesticides is NS (15 March 1997), 48. Studies of Gulf War syndrome are still being expanded, Lancet 349 (1997), 707, 931.

The cigarette group, Ligget, has admitted that cigarettes cause cancer and nicotine is addictive, and will pay a percentage of its earnings, Newsweek (31 March 1997), 44; Time (31 March 1997), 26-9; NS (29 March 1997), 3: Lancet 349 (1997), 932; JAMA 277 (1997), 751-3. Other tobacco companies are still denying it. On strategies to reduce child smoking, JAMA 277 (1997), 778. Maternal smoking is associated with significant expenses for children7s respiratory infections, AJPH 87 (1997), 205-9. A general explanation is Kessler, DA. et al. "The legal and scientific basis for FDA's assertion of jurisdiction over cigarettes and smokeless tobacco", JAMA 277 (1997), 405-9; and on advertising, Gostin, LO. et al. "FDA regulation of tobacco advertising and youth smoking", JAMA 277 (1997), 410-8. Hostility may affect health, and be related to smoking and alcohol, SSM 44 (1997), 1089-96. On industry sponsored research, Lancet 349 (1997), 588, 778. China has banned smoking on trains and buses, BMJ 314 (1997), 772. On methods to measure smoking, AJPH 87 (1997), 56-61, 108-111.

An NIH panel has concluded more study is needed to assess marijuana in medicine, JAMA 277 (1997), 867-8; Lancet 349 (1997), 624; NS (15 March 1997), 14-5. Letters on cocaine are in JAMA 277 (1997), 457-8. On herbal medicines, Lancet 349 (1997), 812; JAMA 277 (1997), 776. Fluoxetine is a contested drug for mental disorders, Lancet 349 (1997), 888. Drug treatments for dementia also raise ethical problems, BMJ 314 (1997), 693-4. Aspirin has been officially recognized as a preventative agent for heart attacks by the FDA, JAMA 277 (1997), 701. The transfer of drugs to developing countries is discussed in Hogerzeil, HV et al. "Guidelines for drug donations", BMJ 314 (1997), 737-40; and on some cases of false labels causing death, NS (29 March 1997), 16-7.

There have been a series of attempted cover-ups in the nuclear industry in Japan in March and April, which has decreased public confidence in the industry, especially in case of major leaks should they occur, Nature 386 (1997), 209. A tritium leak in the USA has shaken confidence also, Nature 386 (1997), 3; as has cancers from Three Mile accident, Lancet 349 (1997), 625; Environmental Health Perspectives 105 (1997), 52-7; and in the UK, Nature 386 (1997), 423; and in France, BMJ 314 (1997), 846. The US and Russia will study radiation effects together in Mayak, Science 275 (1997), 1062-3. There are numerous problems from the dumping of old nuclear submarines, SA (March 1997), 20-2. On the US nuclear clean-up, EST 31 (1997), 134-7A. A public survey is Feldman, DL & Hanahan, RA. "Public perceptions of a radioactively contaminated site: Concerns, remediation preferences, and desired involvement", Environmental Health Perspectives 104 (1996), 1344-52. A study that did not find association between EMF exposure and brain cancer is Occupational & Environmental Medicine 54 (1997), 7-13.

Breast implants are discussed in NEJM 336 (1997), 677-82, 718-9. Letters on whether bicycle helmets should be voluntary are in JAMA 277 (1997), 883-4; and on brain damage in divers, BMJ 314 (1997), 689-90. Owners of automatic guns in the USA also have a tendency for binge drinking, AJPH 87 (1997), 286-8.

A commentary asking how to stop ethical shortcuts in drug trials in developing countries is NS (17 May 1997), 14-5. Japan is also reviewing drug trials, Lancet 349 (1997), 1007. In general on drug validation, GEN (1 June 1997), 1, 14. Medical marijuana is debated in NEJM 336 (1997), 1184-7; AJPH 87 (1997), 585-90. The use of natural mood boosters from the plant Saint Johnswort, Hypericum perforatum, has been increasing; Newsweek (5 May 1997), 58-9. Germany is producing many of Europe's herbal medicines, GEN (15 April 1997), 14, 29.

A study has shown that aspirin benefits stroke patients, though with a small total impact, Lancet 349 (1997), 1563-5, 1569-81, 1641-9; BMJ 314 (1997), 1646. Adverse outcome may be linked to low cholesterol concentration, BMJ 314 (1997), 1584-8.

On 25 April a US Federal judge ruled that the FDA could regulate tobacco, Lancet 349 (1997), 1305. Tobacco companies in the USA may pay US$386 billion as a lawsuit settlement in return for immunity from future prosecution, BMJ 314 (1997), 1217; Newsweek (28 April, 1997), 46-53. A US map showing 1975-1994 deaths by lung cancer in males shows where the tobacco states are, SA (June 1997), 28. Israel plans to sue tobacco companies, BMJ 314 (1997), 1711. On litigation, NEJM 336 (1997), 1832-3. On prevention methods, BMJ 314 (1997), 1371-5. The UK plans to ban advertising, BMJ 314 (1997), 1502. Canada is debating its smoking law proposals, BMJ 314 (1997), 1222; and a book review, JAMA 277 (1997), 1651-2. Romania plans tough laws, BMJ 314 (1997), 1506. The tobacco industry is turning more to developing countries to sell tobacco, NatMed 3 (1997), 594-5. Vietnam has the highest male smoking rate reported in the world, 73% (4% in women), JAMA 277 (1997), 1726-31; BMJ 314 (1997), 1644. WHO wants governments to stop people smoking, BMJ 314 (1997), 1688.

Passive smoking doubles the risk of heart disease, in a US study of 32046 healthy non-smoking women, Circulation 95 (1997), 2374-9; BMJ 314 (1997), 1572; Lancet 349 (1997), 1606. A California study has also been released, JAMA 277 (1997), 1026-7. A memo listing the types of scientists that the tobacco industry buys to support its claim has been found, BMJ 314 (1997), 1569. On funding by tobacco industry, BMJ 314 (1997), 1350-1. The early use of alcohol and tobacco is associated with increase risk taking later in life, AJPH 87 (1997), 359-64. In Japan a survey of 34,000 people found 55% of men, and 13% of women smoke, but 18% of women in 20-30s.

A paper on the excess mortality of air pollution showing consistency across Europe is Katsouyanni, K. et al. "Short term effects of ambient sulphur dioxide and particulate matter on mortality in 12 European cities: Results from time series data from the APHEA project", BMJ 314 (1997), 1658-63. Asthma is one of the diseases, JAMA 277 (1997), 1503-4; and it can also be caused by occupation, Lancet 349 (1997), 1465-9; and indoor allergens like cockroaches, NEJM 336 (1997), 1382-4. Also on asthma, BMJ 314 (1997), 1427-8; Science 276 (1997), 1327. A review of asbestosis and silicosis is Lancet 349 (1997), 1311-5.

The ideal body weight is below the average in terms of survival and quality of life, BMJ 314 (1997), 1291-2. On 14 May the drug Xenical from Hoffman-La Roche received unanimous approval from an FDA committee for use as an antiobesity pill, Lancet 349 (1997), 1529. Another pill that increases metabolism, and mimics adrenaline is being developed, NS (26 April 1997), 11. However drugs should come after diet fails, BMJ 314 (1997), 1643; Lancet 349 (1997), 1374; AJPH 87 (1997), 541-3. On treatment for hypercholesterolemia, JAMA 277 (1997), 1320-1, 1281; JAMA 277 (1997), 1281-6. On obesity research, Nature 387 (1997), 27-8; also a review of company research on the subject is available in a report, <http://www.ibcusa.com/pub/obesity>

A low fat diet can lower blood pressure, Science 276 (1997), 350. Antioxidants are being tested for affects upon heart disease, Lancet 349 (1997), 1710-1; and on dementia, Lancet 349 (1997), 1189. Cooler houses, less activity outdoors and fewer clothes increases risk of heart disease in Europe, Lancet 349 (1997), 1337, 1341-6. The use of defibrillators on Qantas airlines has led to adoption by some other airlines including American Airlines, following the release of figures showing increasing death rates on planes, NS (4 June 1997), 4; Lancet 349 (1997), 1008. On variations in US black and white deaths from cardiovascular disease, NEJM 336 (1997), 1321-2; AJPH 87 (1997), 635-42. Mental stress can trigger myocardial ischemia, JAMA 277 (1997), 1558-9, 1521-6. Cocaine may only have acute effects not broad, AJPH 87 (1997), 629-34.

Activity reduces risk of breast cancer, Thune, I. et al. "Physical activity and the risk of breast cancer", NEJM 336 (1997), 1269-75, 1311-2. Postmenopausal women have lower mortality with more physical activity, JAMA 277 (1997), 1287-92. There is dispute over how much and what type of exercise reduces risk of heart attack, Science 276 (1997), 1324-7. Green tea may prevent cancer due to particular compounds called UPA inhibitors, Nature 387 (1997), 561.

A study of the diseases that we are most likely to die from in 2020 is reviewed in Lancet 349 (1997), 1263; and papers from the Global Burden of Disease Study on mortality, disability, risk factors, life expectancy, include Lancet 349 (1997), 1269-76, 1347-52, 1436-42, 1498-1504. On public health, JAMA 277 (1997), 1579.

Nutrient supplements may improve immunity in elderly persons, Meydani, SN. et al. "Vitamin E supplementation and in vivo immune response in healthy elderly subjects. A randomized controlled trial", JAMA 277 (1997), 1380-6, 1398-9. The persons consumed 200mg/day with no ill effects. A book review of Apple, RD. Vitamania: Vitamins in American Culture, is JAMA 277 (1997), 1247. The effects of religion on people's health is positive in an Israeli study, Kark, JD. et al. "Psychosocial factors among members of religious and secular kibbutzim", Isr. J. Med. Sci. 32 (1996), 185-94.

A genetic response to radiation is Baskaran, R. et al. "Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation", Nature 387 (1997), 516-9; also pp. 520-3. On infant leukemia after Chernobyl, Nature 387 (1997), 246. The UK has decided not to build an underground nuclear waste repository, NS (19 April 1997), 5. Leukemia has been reported around La Hague reprocessing plant in France, but questions are being raised, BMJ 314 (1997), 1553-5; Lancet 349 (1997), 969-70, 1473-9. Japan is also having problems, Nature 387 (1997), 219, 838-9. Radioactivity from Sellafield in the UK has spread around the Arctic, and the iodine is an order of magnitude higher than the signature from the earlier open air atomic bomb tests, NS (10 May 1997), 14. The US NRC has supported open access to test-ban data, Nature 388 (1997), 107.

An Australian study found twice as many immune cell cancers when exposed to levels of EMF similar to cellphone use, Radiation Research 147 (1997), 631; NS (10 May 1997), 4. Cellphones generally do not interfere with pacemakers, NEJM 336 (1997), 1518-9. A Dutch study has been completed on cell phone dangers and it recommends limits for exposure to EMFs, Network 11 (April 1997), 7-11. The US DOE has stopped its research into health effects of EMF radiation from 1998, Science 276 (1997), 1867; and a US study finds no statistical evidence of health effects from power lines, NEJM 336 (4 July 1997).

The presence of pollution appears to be of similar weight to poverty on leading people into crime, NS (31 May 1997), 4. Pesticide poisonings are discussed in Lancet 349 (1997), 1161-6. The impacts of war on society are discussed in Lancet 349 (1997), 1568; JAMA 277 (1997), 1479-80. Children abuse can continue to exert as strong an influence as current abuse, JAMA 277 (1997), 1362-8. On violence, JAMA 277 (1997), 1391-7, 1400-1, 1641-2. Some data suggests males should live longer than females and pursuit of sex shortens their life, NS (24 May 1997), 19.

A call for scientific activism following experience with silicone breast implants is Science 276 (1997), 1524-5; and on differences between women, JAMA 277 (1997), 1643-4, 1612-7. Letters on the diseases caused are Lancet 349 (1997), 1170-3.

A paper calling for greater public discussion of enhancement ethics is Whitehouse, PJ. et al. "Enhancing cognition in the intellectually intact", HCR 27 (1997), 14-22. There are already some drugs available which enhance intellect, and we can expect more in the future. A weekend dose of Ecstasy drug can leave forgetfulness and poor concentration, NS (21 June 1997), 3, 4. The FDA is investigating a slimmer's drug, Redux, NS (28 June 1997), 10; Time (21 July 1997), 35. There is an long term history of drug use in the USA, JAMA 277 (1997), 1919-21; NEJM 337 (1997), 57-9. On cosmetic surgery, J. Health Politics, Policy & Law 22 (1997), 245-51. Dow Corning has raised its settlement offer for implant damages (Detroit, 26 August, 1997, Reuters News).

On the ethics of public health, Mann, JM. "Medicine and public health, ethics and human rights", HCR 27 (1997), 6-13; JAMA 277 (1997), 1894-5; and the ethics of epidemiology, Weed, DL. "Underdetermination and incommensurability in contemporary epidemiology", KIEJ 7 (1997), 107-28; Tancredi L, ed. Ethical Issues in Epidemiologic Research. New Brunswick: Rutgers UP, 1986; J. Clinical Epidemiology 44 (1991), Supplement I.; Coughlin S, ed. Ethics in Epidemiology and Clinical Research, Newton, Mass.: Epidemiology Resources, Inc., 1995. Coughlin S, et al. Case Studies in Public Health Ethics Washington, DC: American Public Health Association, in press. A review of preventive health services in Europe is Int. J. Health Services 27 (1997), 247-71.

There is debate about how much pharmaceutical companies should warn users about the dangers of mixed use, NS (12 July 1997), 20-1. In Japan 39 patients out of 5430 have died as a result of side effects of the anti-cancer drug irinotecan hydrochloride since release in April, 1994; Lancet 350 (1997), 124. On drug treatment guidelines and limits, Lancet 350 (1997), 155, 232-3; JAMA 278 (1997), 179-85. On herbal medicine in China, BMJ 315 (1997), 115-7. The use of home blood pressure control in Japan is reported in Lancet 350 (1997), 290-1. US seeds were suspected in radish shoot cases of E.coli O157 outbreaks in Japan, NatMed 3 (1997), 705-6.

There are still some doubts over whether the US$369 billion deal with 5 major US tobacco companies to pay for health damages caused through tobacco addiction will be the last, NS (28 June 1997), 7; BMJ 314 (1997), 1849; Lancet 349 (1997), 1894; 350 (1997), 1; AJPH 87 (1997), 906-8; NatMed 3 (1997), 712-3. The AMA said it was not enough. On changing public attitudes to smoking, AJPH 87 (1997), 910-2. In Hong Kong record number of smokers have stopped in 1996 and 1997, CMAJ 156 (1997), 1441-5; and they have banned tobacco advertising, BMJ 315 (1997), 8. The Philippines fear that they will be targeted by the US tobacco industry, Lancet 350 (1997), 126; as are other Asian countries, BMJ 315 (1997), 209. Pipe and cigar smokers have greater risk of lung cancer than life-long non-smokers, BMJ 314 (1997), 1860-3. On the method of addiction, NS (5 July 1997), 4; Nursing Research 46 (1997), 155+; JAMA 278 (1997), 339-40. Marijuana may be harder than thought, Science 276 (1997), 1967-8.

Fresh fruits increase lung function in children, Lancet 350 (1997), 120; Thorax 52 (1997), 826-33; and increase the levels of compounds in the blood which reduce cancer risk, BMJ 314 (1997), 1787-91. Vitamin E is particular useful for diabetics, BMJ 314 (1997), 1845-6. Food advertisers will have to avoid saying foods are cures for diseases, according to the FDA, NS (5 July 1997), 15. Higher milk consumption may not protect again bone fractures, AJPH 87 (1997), 992-7. On the dangers to health from herbal teas, FDA Consumer (July-Aug 1997), 6-11. Alcohol consumption appears to delay the onset of menopause, BMJ 315 (1997), 188; but there are class differences in alcohol related mortality, BMJ 315 (1997), 211-6; and heavy consumption is thought to be related to decreased life expectancy in Eastern Europe, J. Health & Social Behavior 38 (1997), 117-30. On the dangers of being overweight throughout different periods of life, BMJ 3145 (1997), 1791-4. Obesity is related to genes in humans as well as mice, NS (28 June 1997), 7. On the relationship between medical genetics and public health, with the change in paradigm of disease prevention, AJMG 71 (1997), 289-91.

An international committee has confirmed a leak between a reprocessing plant at la Hague and increased leukemia, BMJ 314 (1997), 1854. In Japan some drums of radioactive waste have corroded after 30 years storage at Tokai storage facility causing further embarrassment to the authorities, Japan Times (27 August 1997), 1. Arctic people still consume radioactive foods from atomic bomb test residues, NS (21 June 1997), 11. On disposal of plutonium, NS (21 June 1997), 5. On the risks of low level radiation from radon, PNAS 94 (1997), 5996-7. EMF and health risks are debated in Science 277 (1997), 29; Occupational and Environmental Medicine 54 (1997), 396-402; NEJM 337 (1997), 1-7, 44-6. ES cell lines with increased sensitivity that can be used for research are reported in PNAS 94 (1997), 8076-81. Cellular telephones do present risks of traffic accident, NEJM 337 (1997), 127-9.

A conference report on reducing the risks of UV exposure, is CMAJ 157 (1997), 175-7; Chronic Diseases in Canada 18(1, 1997) (see also environment section above). On the dangers of working too long, Occupational & Environmental Medicine 54 (1997), 367-75; Am. J. Occup. Env. Med. (1997), 556+. A review of industrial disease is Lancet 350 (1997), 226. The difficulties of measuring lifestyle by questionnaire are discussed in J. Public Health Med. 19 (1997), 203-7, 219-21.

A call for South-North research collaborations to study pesticides is in Wesseling C. et al. "Agricultural pesticide use in developing countries: health effects and research needs", Int. J. Health Sciences 27 (1997), 273-308. Pesticides are linked with a fish sex imbalance in the USA, EST 31 (1997), 3123A. On dioxin in foods, Lancet 350 (1997), 267. The range of chemical substances in human society from perfumes and other materials is often linked to disease, NS (21 June 1997), 30-5. Dicophane (DDE) does not appear to increase breast cancer in European women, BMJ 315 (1997), 81-5. On biomarkers (see also Environment section), EST 31 (1997), 1837-48. A scientist died after methyl mercury was absorbed through latex gloves in a spill, while using as a standard, Science 276 (1997), 1797. The powder from surgeons gloves may cause illness, NS (5 July 1997), 5.

Rubber or woodchip surfaces in children's playground decrease injuries, Lancet 349 (1997), 1874-6. Calls to decrease weapons sales are in NS (5 July 1997), 18-9; Lancet 350 (1997), 63; BMJ 315 (1997), 72, 135. Guns are linked to violence, AJPH 87 (1997), 899-900, 918-21, 974-8. Brief periods of exposure to benzodiazepines are associated with increased risk of motor vehicle crashes in the elderly, JAMA 278 (1997), 27-31, 66-7. On the psychology of the Aum cult violence in Japan, JAMA 278 (1997), 191-3.

A study found doctor's expectations of what the patient's wanted was the strongest determinant of prescribing in a UK study, BMJ 315 (1997), 520-3. On Spanish drug policy, being the 7th largest drug market in the world, Lancet 350 (1997), 679-80. WHO drug control is debated in Lancet 350 (1997), 601. On US FDA reform, JAMA 278 (1997), 459; BMJ 315 (1997), 447. The AMA has started to endorse some products, BMJ 315 (1997), 445. A call for more research on medical marijuana has been made by a NIH panel, JAMA 278 (1997), 802; NEJM 337 (1997), 435-9; whereas Dutch coffee shops are providing it at cost price, BMJ 315 (1997), 504. A study showing advantages of direct reporting by hospital pharmacists on adverse drug reactions is BMJ 315 (1997), 519. On the growing desire for alternative medicines and homeopathy, NS (27 Sept. 1997), 3; NatMed 3 (1997), 824-7; Nature 388 (1997), 842. Thalidomide will be licensed as a leprosy treatment, BMJ 315 (1997), 699; and it is probably not a mutagen so those affected can have children without so much fear, Nature 389 (1997), 118.

On health promotion and public health, BMJ 315 (1997), 361-3, 694-5. On false diagnosis, NS (27 Sept. 1997), 38-41. The Swedish Institute for Health Service Development, Spri, has been set up to strengthen position of patients in research and form better priority of projects; contact Spri, Box 70487, S-107 26 Stockholm, Sweden. A study of affects of commuting on health in Japan is Lancet 350 (1997), 639. The personality trait of submissiveness may be associated with less heart attacks, Whiteman, MC et al. "Submissiveness and protection from coronary heart disease in the general population: Edinburgh Artery Study", Lancet 350 (1997), 541-5. A comparison of 27 variable for heart disease is in BMJ 315 (1997), 722-9; and on fish, NEJM 337 (1997), 497-9.

A rat that grows 1.4kg as a model of obesity has been made in India, NatMed 3 (1997), 823. A call for a more ecological approach to the obesity pandemic is made in BMJ 315 (1997), 477-80; and also on obesity, Lancet 350 (1997), 423-6; NEJM 337 (1997), 869-73, 926-7. There are many diet pills, NEJM 337 (1997), 629-30. On diet and health: BMJ 315 (1997), 404-5; NEJM 337 (1997), 562-7; antioxidants, Lancet 350 (1997), 667-8; vitamin B6, Nature 389 (1997), 7; herbal tea dangers, FDA Consumer (July/Aug. 1997), 6-11. The addition of vitamin B1 to wheat is debated in NS (13 Sept. 1997), 54. Predatory trout grow faster in the presence of a competitor, NS (30 Aug. 1997), 8. Iodine supplements increased infant health in China, Lancet 350 (1997), 771-3.

Calcium supplements has a mild positive effect on bone fractures and bone loss in elderly patients, NEJM 337 (1997), 670-6. There does not seem to be much affect on bone loss during breast feeding, NEJM 337 (1997), 523-8, 558-9. Other diet elements may also have some effect, NEJM 337 (1997), 701-2. Letters on breast implants are in JAMA 278 (1997), 818-9; Lancet 350 (1997), 648, 740-1.

Reports from the tobacco conference held in China, the world's largest consumer and producer of tobacco are BMJ 315 (1997), 440-1, 448, 502, 565. Also on ethics and tobacco, Siegel, M. et al. "Preemption in tobacco control. Review of an emerging public health problem", JAMA 278 (1997), 858-63. IDHL 48 (1997), 250-2. There are still debates over the US tobacco compensation deal for US$368 billion over 25 years, NatMed 3 (1997), 81; BMJ 315 (1997), 564; Lancet 350 (1997), 303. The US has banned smoking on federal property, BMJ 315 (1997), 384; Lancet 350 (1997), 571; but in Australia bans are not always working, Lancet 350 (1997), 721. On efforts to ban advertising of tobacco, BMJ 315 (1997), 439-40. Taxes from tobacco will be increased to give money to diabetes research and screening, NatMed 3 (1997), 939. There is much debate however over decisions to stop tobacco companies funding research, Science 277 (1997), 755. Molecular studies can identify which mutations are caused by which chemicals, NS (2 Aug. 1997), 20. The substances are also seen in second hand smoke, like NNK, NS (20 Sept. 1997), 13. A study of the race concept in US use within smoking studies is SSM 45 (1997), 1075-87. Exercise studies can identify persons at highest risk of heart attack due to smoking, Lancet 350 (1997), 495. Africa may be the next target of US/European companies, Lancet 350 (1997), 792.

An environmental genome project is planned to resequence genes implicated in environmental carcinogenesis by the US National Institute of Environmental Health Sciences (NIEHS, Research Triangle Park, NC). The Environmental Genome Project (EGP) will attempt to build "the capacity for correlating individual genetic differences with exposure outcomes so that exposure-disease relationships can be more precisely addressed," says Sam Wilson, deputy director of NIEHS. Nature Biotechnology 15 (1997), 939.

Water fluoridation is associated with dental hygiene benefits more in poor areas than wealthy ones, BMJ 315 (1997), 514-7. Maternal lead ingestion increases caries in rats, NatMed 3 (1997), 956. Lead levels in USA are dropping, EST 31(1997), 424-9A. On marijuana addiction, Science 277 (1997), 749-52; and on alcohol addiction, BMJ 315 (1997), 358-60. It is thought to be responsible for health decline in Russian men, BMJ 315 (1997), 386; Lancet 350 (1997), 379, 383-8. On the perils of drowsy driving, NEJM 337 (1997), 783-4.

Also on the EMF/health debate, NS (9 Aug. 1997), 3, 16-7. A proposal that plants can use electric fields to signal eminent climatic changes is discussed in NS (23 Aug. 1997), 28-31. Mutation in barn swallows around Chernobyl is 2-10 times higher, Nature 389 (1997), 593-6. Nuclear test fallout in the US may result in from 10-75,000 extra cases of thyroid cancer, BMJ 315 (1997), 329; Lancet 350 (1997), 415. There have also been extra revelations of personnel from military in the USA being exposed to radiation, BMJ 315 (1997), 566; Nature 389 (1997), 534; in addition to UK cases, Lancet 350 (1997), 649. The problems of bioaccumulation of radioactive isotopes by crustaceans around atolls means they are not a good place for dumping waste [if any is], NS (27 Sept. 1997), 4. Plutonium from Sellafield is being found in teeth of growing children across the UK, NS (2 Aug. 1997), 16; and increased leukemia is found around other nuclear sites in the UK, BMJ 315 (1997), 309. The site for disposal is still to be decided, Nature 389 (1997), 428; NS (16 Aug. 1997), 10. A Taiwanese study has found cytogenetic damage in persons living in buildings built with cobalt-60-contaminated steel, Lancet 350 (1997), 330-3.

French ministries are arguing over the impact of the report on health dangers of asbestos, Nature 389 (1997), 649-50. On air pollution and lung damage, Env. Health Persp. 103 (1995), 852-6; and coal dust, NS (27 Sept. 1997), 20-1. A study of allergies to oilseed rape emissions has found only a few individuals are affected, but more study is called for, Lancet 350 (1997), 458-9. Hydrofluorocarbons that are substituting for CFCs are related to liver disease, Lancet 350 (1997), 556-9. A USDA food survey found many pesticides, on 65% of fruits and vegetables sold in USA, but 4% violated EPA limits, EST 31 (1997), 406-7A. California Prop. 65 is a right to know all such details, EST 31 (1997), 368-9A.

The risks of violence increase in houses with alcohol or illicit drug use, JAMA 278 (1997), 569-75. A series of papers on violence and health is in SSM 45 (1997), 1143-98. There is debate over the safety of CS sprays for crowd control, Lancet 350 (1997), 605. A review of crime is Sampson, RJ. et al. "Neighborhoods and violent crime: A multilevel study of collective efficacy", Science 277 (1997), 918-24.

The US FDA has new guidelines, JAMA 278 (1997), 946-7; GEN 17 (15 Oct 1997), 1, 10, 38; Lancet 350 (1997), 1153, 1690. The law allows companies to distribute peer-reviewed journal articles on off-label uses to doctors. Fast-track processes are included, trials on pediatric patients will have market exclusive period extended, and allowing health claims on foods. WHO is considering regulating Ads, and sale of products on the Internet, JAMA 278 (1997), 1723-4. A comment on men, women and animals used in drug advertisements is BMJ 315 (1997), 1550. On alternative medicines integration in the USA, JAMA 278 (1997), 2111-2; NatMed 3 (1997), 1306-7. Further trials of homeopathy are suggested although no definitive results are shown in trials in Lancet 350 (1997), 834-43, 824-5. On the influences to make doctors prescribe, BMJ 315 (1997), 1482-3. On risk adjustment, JAMA 278 (1997), 1600--7. Personal use of drug samples is discussed in JAMA 278 (1997), 1567-9.

Donation of the anti-malarial drug malarone may be related to development of resistance if used improperly, Lancet 350 (1997), 1624-5, 1628. On inappropriate drug donation practices in Bosnia, NEJM 337 (1997), 1842-5. The FDA has found no major danger from Halcion, Lancet 350 (1997), 1760. Letters on use of statins are in BMJ 315 (1997), 826-7, 1554-5, 1615-20. About 65% of the 751 instances of counterfeit drugs notified to WHO in the past 15 years have been produced in developing countries, Lancet 350 (1997), 1690; BMJ 315 (1997), 1557; Time (26 Jan 1997), 42-4. A call for greater information to patients and doctors when new drugs are approved is made BMJ 315 (1997), 1248-9; and on consumer reports, JAMA 278 (1997), 1579-84.

A survey of health behavior in Australian 18 year olds is SSM 45 (1997), 1549-62. On health behaviour of Hindus and Sikhs and Europeans, Lancet 350 (1997), 1578-83. Bed-rails should be modified to reduce injury, AJPH 87 (1997), 1675-7. A review is Brown, SL. et al. "Rupture of silicone-gel breast implants: causes, sequelae, and diagnosis", Lancet 350 (1997), 1531-7. On women in clinical trials, NatMed 3 (1997), 1179-80. There is a plan to register unpublished epidemiology studies, Science 277 (1997), 1754.

With the return of thalidomide, there are calls for monitoring of birth defects, AJMG 73 (1997), 251-8; NatBio 15 (1997), 1238; Lancet 350 (1997), 873; JAMA 278 (1997), 1135-7. Anti-obesity drugs, Pondimin and Redux have been withdrawn from the market as a link to heart valve defects is tested, Lancet 350 (1997), 867; BMJ 315 (1997), 1329. A biosensor for genotoxin screening in recombinant E. coli cells is reported in AEM 63 (1997), 4377-84.

Suspicions of food safety are high after diseases like BSE, and E. coli, Lancet 350 (1997), 1234; Science 278 (1997), 1887; but regulations in the UK have decreased incidence, BMJ 315 (1997), 1114. There is often too much information, JAMA 278 (1997), 1052-3; NS (18 Oct 1997), Supplement 1-4. On the dangers of red meat consumption and what is a safe level, Lancet 350 (1997), 1007; BMJ 315 (1997), 1018. Healthy eating has health benefits as shown in a Vietnam child program, BMJ 315 (1997), 1122-5; and high milk consumption in girls increases bone mass, BMJ 315 (1997), 1255-60. Modest reduction in salt consumption in older people leads to reduced blood pressure, Lancet 350 (1997), 850-4. Women with high consumption of phyto-estrogens have lower rate of breast cancer, Lancet 350 (1997), 990-74, 971-2; as do lighter women, JAMA 278 (1997), 1407-11. Xenoestrogens may be related to cancer, NEJM 337 (1997), 1303-4, 1686-7; Time (1 Dec 1997), 55.

An extract of Ginkgo biloba can be used for dementia treatment, JAMA 278 (1997), 1327-32. Multivitamin and vitamin E consumption leads to less colon cancer risk, Lancet 350 (1997), 1452; Cancer Epidemiol. Biomarkers Prev. 6 (1997), 769-74. If antioxidant vitamins are taken with a high fat meal the endothelial function is not reduced, JAMA 278 (1997), 1682-6. Too much is bad however, Time (6 Dec 1997). Fat quantity rather than quality may be related to heart disease risk, Lancet 350 (1997), 1603; BMJ 315 (1997), 997-1000; NEJM 337 (1997), 1491-9, 1544-5. Caloric restriction may retard cancers, BMJ 315 (1997), 1332; NS (15 Nov 1997), 15; and aging, NEJM 337 (1997), 986-8. A call for checking cholesterol levels health affects in elderly patients is Lancet 350 (1997), 1119-23. A review on jet-lag is Lancet 350 (1997), 1611-6. On SF-36 questionnaire to assess health, BMJ 315 (1997), 1273-9. A review of diet and cancer links is JAMA 278 (1997), 1650-1; and on cancer, Science 278 (1997), 995.

On environmental affects on human health see the Environment section; also, JAMA 278 (1997), 1793; AJPH 87 (1997), 1798-807; Sellers, C. "Discovering environmental cancer: Wilhelm Hueper, Post-World War II epidemiology, and the vanishing clinician's eye", AJPH 87 (1997), 1824-35. Gulf-war illness appears to be vaccine side effects (see Vaccine section), also, Nature 390 (1997), 4. Mortality of coal miners is reviewed in Occup. Env. Med. 54 (1997), 708-13. On health and child labour, Lancet 350 (1997), 1395-6; and work conditions in general, Lancet 350 (1997), 1187. There is an East-West European gap in mortality, Lancet 350 (1997), 1255. On liver abnormalities caused by HCFCs, Lancet 350 (1997), 1248-9. On controls for age affects in occupational epidemiology, Occup. Env. Med. 54 (1997), 769, 772-6. On hazards of lead paint in houses, AJPH 87 (1997), 1698-702, 1871; and mercury in fish, NS (22 Nov 1997), 3; Science 278 (1997), 1904-5.

Smoking cessation may be cost effective to reduce health care costs, JAMA 278 (1997), 1759-66; but eventually all will die and costs may not be so different claims one study, NEJM 337 (1997), 1052-7. A study of the impact of US tobacco restrictions is JAMA 278 (1997), 2055-7. US flight attendants have received damages for exposure to smoke, BMJ 315 (1997), 968. Smoke-free ordinances do not adversely affect bar or restaurant sales in USA, AJPH 87 (1997), 1687-93; and laws may reduce use, NEJM 337 (1997), 1044-51. On tobacco politics, AJPH 87 (1997), 1593-5; Lancet 350 (1997), 890; NatMed 3 (1997), 1305; BMJ 315 (1997), 961-2, 1037; JAMA 278 (1997), 1028; NEJM 337 (1997), 1082-3; Science 278 (1997), 203. The UK Cancer Research Campaign has said it will no longer fund any work if a Department or Faculty received money from tobacco companies, BMJ 315 (1997), 967. A Brazilian cigarette company has been fined for premature death caused by smoking, Lancet 350 (1997), 1014. A review is Hackshaw, AK. et al. "The accumulated evidence on lung cancer and environmental tobacco smoke", BMJ 315 (1997), 980-8; hip fracture in old age increases, BMJ 315 (1997), 841-6; and on heart disease, BMJ 315 (1997), 973-80; also see PNAS 94 (1997), 13915-20. Nicotine activates and desensitizes midbrain dopamine neurons, Nature 390 (1997), 401-4; and acetylcholine receptors are involved, Nature 391 (1998), 173-7; but on whether to increase or decrease nicotine levels is unsure, NEJM 337 (1997), 1230-1. On motor racing influence and exemptions to the UK tobacco advertising ban, Lancet 350 (1997), 1411, 1474; BMJ 315 (1997), 763, 1251, 1325-6, 1397. Europe has agreed to a total tobacco ban by 2006, BMJ 315 (1997), 1559; one can ask why a decade late? Australian law courts have judged in favour of people with asthma to be guarantied a smoke free interior, BMJ 315 (1997), 904. Tobacco damage in China is reported in JAMA 278 (1997), 1505-8, 1531-2; Science 277 (1997), 1769.

Alcohol problems are another avoidable health risk, discussed in JAMA 278 (1997), 1755-8, 1781-2; Lancet 350 (1997), 956-7; BMJ 315 (1997), 1179, 1637-9, 1664-8; Moderate consumption reduces mortality in US middle or old aged adults, NEJM 337 (1997), 1705-14, 1763-4. A social perspective is Warner, J. "Shifting categories of the social harms associated with alcohol: Examples from late Medieval and early modern England", AJPH 87 (1997), 1788-97. On substance abuse, J. Rehabilitation (Oct 1997), 5+; Time (19 Jan 1998), 35. Doctors have ambivalent attitudes, BMJ 315 (1997), 1297-9. Alcohol may protect, and coffee increase risk, of Helicobacter pylori infection, BMJ 315 (1997), 1489-92. The BMA wants the licensing of cannabis changed to allow trials, BMJ 315 (1997), 1329; the NIH has funded a marijuana study, Science 278 (1997), 211; and a book review is Science 278 (1997), 75. Several papers on addiction are in Science 278 (1997), 15, 45-63, including Dutch cannabis policy and on genetic and hormonal factors.

Air bags can reduce fatalities from car crashes, JAMA 278 (1997), 1418-25, 1437-9. The ban on landmines has ethical backing, comments include, Lancet 350 (1997), 891-2, 941; BMJ 315 (1997), 1450-2; and on banning blinding lasers, BMJ 315 (1997), 1392. The effects of gun laws on firearm mortality, JAMA 278 (1997), 1084-6. Violence is often found in TV commercials as well, JAMA 278 (1997), 1045-6.

The largest ever study of its kind finds a role of radiation exposure of fathers to childhood cancers, Draper, GJ. et al. "Cancer in the offspring of radiation workers: a record linkage study", BMJ 315 (1997), 1181-8, 1232-5; Nature 390 (1997), 107; Ecologist 27 (1997), 170-2; NS (11 Oct 1997), 36-40; (15 Nov 1997), 3-5. Taiwan has compensated residents exposed to radiation from their apartment buildings that used radioactive building components, Lancet 350 (1997), 1232. There is increased nuclear debate in France, Nature 390 (1997), 322. A retraction of a paper reporting high levels of DNA change in rodents around Chernobyl is Nature 390 (1997), 100; and a study is underway to examine affects of um sized metal particles from Chernobyl, NS (20 Dec 1997),15. Radiation therapy after retinoblastoma treatment could lead to more cancer, JAMA 278 (1997), 1262-7. An atmospheric study of radionuclides finds seasonal variation, Naturwissenschaften 84 (1997), 535-9. A shipment of highly radioactive nuclear waste -- the third and largest ever shipment to date -- is departing France for Japan in January 1998. This third shipment will be carrying 60 blocks of vitrified (glassified) high-level radioactive waste thus containing more than 2000 times the radioactivity of the Hiroshima fallout. The movement against the nuclear imports to Japan can be contacted, Green Action, 22-75-103, Tanaka Sekiden-cho, Sakyo-ku, Kyoto 606-8203, JAPAN. Tel: 075-701-7223. Fax: 075-702-1952. Email: amsmith@gol.com. The costs of nuclear cleanup are very high, NS (6 Dec 1997), 3, 15; (13 Dec 1997), 3, 14; EST 31 (1997), 458A, 510-4A. Atomic fingerprints may be used to monitor ships that dump oil at sea, NS (8 Nov 1997), 23.

Researchers are testing if cell phones affect memory, SA (Dec 1997), 20. Exposure to magnetic fields and leukemia is debated in NEJM 337 (1997), 1471-4. Letters on cardiac pacemakers and cellular telephone effects are in NEJM 337 (1997), 1006-8. A call for reducing radio wave pollution is Nature 390 (1997), 101, 103.

There are calls to legalize use of marijuana for medical purposes in Canada, CMAJ 158 (1998), 373-6; and book reviews of the subject, BMJ 316 (1998), 239; Lancet 350 (1997), 1828. The Malaysian Ministry of Health has given traditional medicine manufacturers until the end of 1998 to comply with Good Manufacturing Practices guidelines, New Strait Times (21 Feb. 1998), 4. On regulation of herbs, SA (Feb. 1998), 30, 32. There may be no clear benefit from moderate drinking of alcohol, Science 279 (1998), 991. It is difficult to determine the alcohol concentration in postmortem samples, BMJ 316 (1998), 87. A report on the battle to set drug prices in New Zealand is Lancet 351 (1998), 195. On the use of aspirin instead of statin, Lancet 351 (1998), 227-8.

A review of the burial of radioactive waste under the seabed is SA (Jan 1998), 60-5. The world's worst radioactive contamination is around the Mayak Production Association in the Urals, by Kasli, EST 32 (1998), 80A. The introduction of microbial nutrients into nuclear waste disposal vaults may increase bacterial levels by 20 times, EST 32 (1998), 317-26. The UK wants to earn money from US nuclear waste reprocessing, NS (31 Jan. 1998), 11.

A discussion of whether electric fields cause cancer is SA (March 1998), 33-4; Lancet 351 (1998), 276. Letters on health effects of acute exposure to EMF are in Occup. Environ. Med. 55 (1998), 144. It has been found that applying changing magnetic fields to the brain helps neurons form new connections. Discussion of how to reduce skin cancer is MJA 167 (1997), 515-6.

The failure of people to follow resolutions to reduce weight is discussed in NEJM 338 (1998), 52-4; and obesity, Nature 391 (1998), 759; NEJM 338 (1998), 1-7, 127-9; Lancet 351 (1998), 194. Walking in old age reduces overall mortality, NEJM 338 (1998), 94-9. On labeling of fat-reduced milk products, FDA Consumer (Jan. 1998), 22-5. Consumption of fish at least once a week reduces risk of sudden cardiac death in men, JAMA 279 (1998), 23-8, 65-6. Consuming high levels of vitamin B6 and folate may decrease women's rate of heart disease. Not eating vegetables and fruits poses a greater risk to health then not eating them even if they contain pesticide residues, Cancer 80 (1997), 2019-33. A study of the reason why some food aid was sold in Africa from camps is that it was a shortage of some items not excess, Lancet 351 (1998), 128-30. On stress mediators, NEJM 338 (1998), 171-9; SA (Jan. 1998), 28-9.

Some children receive silicone through placenta and milk from mother's who have breast implants, Lancet 351 (1998), 349. Also on breast implants, Nyren, O. et al. "Risk of connective tissue disease and related disorders among women with breast implants: a nation-wide retrospective cohort study in Sweden", BMJ 316 (1998), 417-22, 403-4. PVCs are implicated in testicular cancer, NS (24 Jan. 1998), 13. On phyto-estrogens and breast cancer, Lancet 351 (1998), 137-9 A review of cancer in the rubber industry is Occup. Environ. Med. 55 (1998), 1-12. In general on cancer risks, BMJ 316 (1998), 318.

Brown and Williamson Tobacco has admitted that the company used genetically modified tobacco with enhanced nicotine levels, and continued despite assurances 4 years ago that it stopped the practice; Science 279 (1998), 317. Drs. CE. Koop and D. Kessler have said that they oppose giving tobacco companies protection against further legal suits in a tobacco settlement, 18 Feb. 1998. Also on US tobacco action, Lancet 351 (1998), 276, 476; AJPH 87 (1997), 1989-96, 2042-4. A call for advertising bans is Lancet 350 (1997), 1831; and on tobacco control, BMJ 316 (1998), 321; Lancet 351 (1998), 451-2; Nursing Times (4 Feb 1998), 42; Environmental Research 75 (1997), 95-9. Heavy smoking may cause irreversible damage to arteries, BMJ 316 (1998), 250; and passive smoking advances atherosclerosis, Lancet 351 (1998), 189; JAMA 279 (1998), 119, 125-9, 157-8; as well as other costs, NEJM 338 (1998), 470-3; Science 279 (1998), 796. A doctor in the Netherlands who refused to treat patients who smoked has been warned that he should by the government, BMJ 316 (1998), 250.

On the ethics of controlling driving in persons with dementia, MJA 167 (1997), 406-7.

A review of the risks of dermal exposure is EST 32 81998), 134-7A; and on toxicity in general, EST 32 (1998), 138-44A. A study of mortality in synthetic rubber workers is Occup. Environ. Med. 55 (1998), 230-5; and on exposure to lead and neuropsychological dysfunction, Occup. Environ. Med. 55 (1998), 202-9. The US Senate is supporting a large study into chemical risks, Science 279 (1998), 1839. A conference report of the role of human neurobehavioural tests in regulatory activity on chemicals is Occup. Environ. Med. 55 (1998), 210-4. In general on public health, Lancet 351 (1998), 590-2; MJA 168 (1998), 228-30; AJPH 88 (1998), 188-92.

There are concerns again about the pesticide ivermectin used in Scottish salmon farms, NS (7 Feb. 1998), 23. A fuel additive called methyl tertiary-butyl ether is building up in water reservoirs in the USA, NS (7 Feb. 1998), 22.

The US Dept. of Defense has not explained to the FDA why it broke rules in the delivering of vaccines against tickborne encephalitis in Bosnia, NatMed 4 (1998), 255. The use of calcium channel blockers may increase the risk of suicide, BMJ 316 (1998), 741-3; NEJM 337 (1998), 679-80. On the prescribing of psychotropic medications, JAMA 279 (1998), 526-31. The drug acetaminophen is a risk factor for excessive warfarin anticoagulation, JAMA 279 (1998), 657-62. A commentary on the export of expired drugs to developing countries is SA (April 1998), 31-2. The drug tamoxifen appears to reduce breast cancer risks.

A study from 1919 shows illicit drug use increased after WWII, AJPH 88 (1998), 27-33. On the Swiss heroin trials, BMJ 316 (1998), 639; and substance abuse, AJPH 88 (1998), 9-11. A study of how households affect drinking is SSM 46 (1998), 971-9. Efforts to increase public health are discussed in Lancet 351 (1998), 463, 687. Social stress is related to the high Russian mortality, JAMA 279 (1998), 790-1, 793-800. Methods to measure the burden of disease are discussed in AJPH 88 (1998), 196-202. Unfavourable diet in childhood can increase cancer risk in later life, BMJ 316 (1998), 499-504; NatMed 4 (1998), 465-6; and estrogen derivatives in the body are related to cancer, Science 279 (1998), 1631-3. Moderate wine drinking decreases mortality in a French study, BMJ 316 (1998), 648.

A new obesity mediator has been found, orexin A and B, Cell 92 (1998), 573-83; BMJ 316 (1998), 649. In March the FDA failed to approve Xenical a new anti-obesity drug, as the panel was split, Lancet 351 (1998), 885.Fast foods and access to televised entertainment may contribute to obesity in the USA, AJPH 88 (1998), 277-80. Also on obesity, Lancet 351 (1998), 888, 903-4; and QOL in obese persons, Lancet 351 (1998), 853-6. Very low fat diets can cause harm to some people, BMJ 316 (1998), 573.

Vitamin C exhibits pro-oxidant properties, Nature 392 (1998), 559. There is also a need for more vitamin D, NEJM 337 (1998), 828-9; and vitamin E may affect immune response, JAMA 279 (1998), 505-6. How to control claims of healthy foods is discussed in Lancet 351 (1998), 609. There is controversy in the UK over a report The Nutritional Aspects of the Development of Cancer (HMSO 1998) which makes dietary suggestions, BMJ 316 (1998), 798. People with high levels of homocysteine and low levels of folate in the blood are at higher risk of heart disease, Lancet 351 (1998), 502; BMJ 316 (1998), 498. A US study of sodium intake could not make specific recommendations, Lancet 351 (1998), 781-5. US and Japanese scientists are disputing the presence of E.coli O157 in radish sprouts, Nature 392 (1998), 642. A letter describing why figs are the preferred food by many animals is Nature 392 (1998), 668.

A survey of spices around the world has shown that they reduce the effects of food-borne disease, Nature 392 (1998), 649-50. A review is Borchers, AT. et al. "Complementary medicine: a review of immunomodulatory effects of Chinese herbal medicines", Amer. J. Clin. Nutrition 66 (1997), 1303-12. Baxter Healthcare has offered between C$7-70,000 per woman who had ill effects from silicone breast implants, Lancet 351 (1998), 508; BMJ 316 (1998), 574. On the rupture of implants, Lancet 351 (1998), 520-1. Nancy Reagan's breast mastectomy increased the use of surgery in US women, JAMA 279 (1998), 762-6.

The growth of tobacco sales in Asia is reviewed in Asian Business Review (March 1998), 31-4; Lancet 351 (1998), 889. The US tobacco settlement with the federal government is now considered a dead deal as the government is seeking more damages from the companies; BMJ 316 (1998), 803. A new policy is needed, JAMA 279 (1998), 550-1. Germany has rejected a ban on smoking in public places, BMJ 316 (1998), 496; despite the growing presence of these bans, BMJ 316 (1998), 727-30, 881. Predictors of smokeless tobacco use are discussed in AJPH 88 (1998), 20-6; and of smoking in adolescents, AJPH 88 (1998), 104-7; and on adolescent exposure to tobacco adverts, JAMA 279 (1998), 511-5, 516-20, 772-7; BMJ 316 (1998), 712. Industry's voluntary ban on all television, radio, cinema and Internet advertising of tobacco in Japan went into effect on 1 April, 1998, Lancet 351 (1998), 579. Public resistance to passive smoking is discussed in Lancet 351 (1998), 845; and it causes health damage, Science News 153 (1998), 36; Lancet 351 (1998), 503, 807; BMJ 316 (1998), 945; CMAJ 158 (1998), 1178-80. Increased effort to public health efforts to stop smoking are called for in SSM 46 (1998), 703-17. There has not been a continued decline in Australian smoking in 1995, MJA 168 (1998), 204-5, 209-13. British patients can sue tobacco companies, BMJ 316 (1998), 571. On the health hazards, Nature 392 (1998), 122.

The standard radiation safety limits need to be revised to protect young and old persons, NS (28 Feb. 1998), 12. On Yucca mountain nuclear deposit, Science 279 (1998), 2040-1. A review is Lacy-Hulbert, A. et al. "Biological responses to electromagnetic fields", FASEB J 12 (1998), 395-420. Some EMF effects are through hormones, Science News 153 (10 Jan 1998), 29-31. Television broadcasts can be linked to seizures in photosensitive persons, NatMed 4 (1998), 265-6.

Letters on cost-effectiveness of airbags are in JAMA 279 (1998), 506-7. The export of weapons of torture is criticized in Time (6 April 1998), 30-1.

Papers on the globalization of public health are in, AJPH 88 (1998), 735-4. On the roles of WHO, BMJ 316 (1998), 1402-4; Science 280 (1998), 2027. On public health in general, BMJ 316 (1998), 951-2. Adverse reactions to drugs should be better reported but they may not be preventable, JAMA 279 (1998), 1200-5, 1216-7; NS (27 June 1998), 3. There are some dangers of giving public direct access to pharmaceuticals, Lancet 351 (1998), 921. FDA funding may imperil safety of products even in USA, JAMA 279 (1998), 899-901. Attention deficit disorder is also under-diagnosed, BMJ 311 (1998), 1594-6.

The Dow Corning Corporation has suggested a US$3.2 billion bankruptcy plan for 400,000 women regarding silicone breast implant damage in early July, 1998. There is an attempt to ban them in Europe, BMJ 316 (1998), 1040; see also Lancet 351 (1998), 1358-9. A new Internet-based electronic certification system for bovine serum imported into Europe from New Zealand is being used to stop serum forgers from using the countries disease free name, NatBio 16 (1998), 503.

Use of vitamins A, C and E for cancer prevention are discussed in CMAJ 158 (1998), 1483-90; Lancet 351 (1998), 961, 1523; and for heart disease including folic acid, Lancet 351 (1998), 11; NEJM 337 (1998), 1009-15, 1060-1. Genistein may be one of e ingredients in soybean that is an anticancer substance, NS (14 March 1998), 14. There is debate over the way tamoxifen should be used for lessening cancer risk, Lancet 351 (1998), 1107, 1451-67; BMJ 316 (1998), 1557. Aspirin can help lessen risk of heart attacks over at least 10 years, BMJ 316 (1998), 1337-43. Placebos can have major effects, Lancet 351 (1998), 1722-5; NEJM 337 (1998), 1236-7; Science 280 (1998), 1901-2; as can alternative medicine, JAMA 279 (1998), 1548-53. There is much criticism of the side effects of Viagra, a pill to increase sexual erections in males, BMJ 316 (1998), 1755; Lancet 351 (1998), 1635; JAMA 279 (1998), 1684; NS (16 May 1998), 14. The first Japanese user died in early July. Israel has banned its import, after 6 deaths in the USA, BMJ 316 (1998), 1625.

A paper on injuries associated with the farm harvest in Canada is in CMAJ 158 (1998), 1493-8. The contribution of environment to breast cancer risk is discussed in Lancet 351 (1998), 1791. Exercise can help, NEJM 337 (1998), 1269-75, 1311-2; also for heart disease, Lancet 351 (1998), 1603-8. Factors that influence car travel for children are analyzed in BMJ 316 (1998), 1426-8. Lung cancer from work is reviewed in Environmental Research 76 (1998), 78-84. Asbestos is a carcinogen, NEJM 337 (1998), 1618-9. Rugby injuries continue to show it is a dangerous game, MJA 168 (1998), 379-81; but boxing should be banned according to many, BMJ 316 (1998), 1813-5. Efforts to stop violence in children are discussed in JAMA 279 (1998), 1853; NEJM 337 (1998), 1375-6; BMJ 316 (1998), 1551. On Cambodia, BMJ 316 (1998), 1082-6. Racial factors on mortality appear to be from income disparity, Lancet 351 (1998), 934-9; NEJM 337 (1998), 1321-2; JAMA 279 (1998), 1703-8. On gender as a determinant, SSM 46 (1998), 1417-24.

Obesity rates are rising, Science 280 (1998), 1364-8; NEJM 337 (1998), 1156-8. On ethnic foods, Nature 393 (1998), 427-8; and on the protection given by spices, Quarterly Review of Biology 73 (1998), 3-84. The FDA has declared the fat substitute, Olestra safe, BMJ 316 (1998), 1926; and on other drugs, Science 280 (1998), 1374-87;MJA 168 (1998), 409+; BMJ 316 (1998), 1241-2, 1956-8. Television may contribute, JAMA 279 (1998), 938-42, 959-60; as may the environment, Science 280 (1998), 1371-4. On heart disease prevention, NEJM 337 (1998), 1690-1; Lancet 351 (1998), 1259; AJPH 88 (1998), 623-9; and biochemistry of obesity, Nature 393 (1998), 684-8; Science 280 (1998), 1369-70; NatMed 4 (1998), 718-21. Stricter limits on pesticide residues are expected on foods in the USA, NS (4 April 1998), 14. On perception of risk, NS (21 Feb. 1998), 16-7; BMJ 316 (1998), 1033-4, 1154-7.

The European Parliament has passed a ban on all direct and indirect advertising of tobacco from 2001, Lancet 351 (1998), 1568; BMJ 316 (1998), 1334. A legal analysis of tobacco regulation is Paralusz, KM. "Ashes to ashes: Why FDA regulation of tobacco advertising may mark the end of the road for the Marlboro man", AJLM XXIV (1998), 89-122. Many tobacco company documents have been released revealing the efforts made to attempt to deny passive smoking risks, NS (2 May 1998), 22; Lancet 351 (1998), 1450; BMJ 316 (1998), 1186, 1923; NS (16 May 1998), 3; SA (July 1998), 30-1. Companies are attempting to subpoena important scientific files, Science 280 (1998), 514-5. Tobacco companies in the USA established networks of sympathetic scientists, BMJ 316 (1998), 1555; NS (16 May 1998), 4-5. A review article written by authors with affiliations to the tobacco industry is 88 times more likely to conclude that passive smoking is not harmful than authors that do not, BMJ 316 (1998), 1554; JAMA 279 (1998), 1566-70. On methods for oral delivery of drugs and peptides, TIBTECH 16 (1998), 152-7. A UK nurse's case against passive smoking exposure reached the UK High Court but she lost, in which she claims her asthma made who leave a job where she had to be in a communal lounge with smokers, BMJ 316 (1998), 1477, 1629.

A study on school attempts to stop smoking is AJPH 88 (1998), 940-3; children may be learning at home also, AJPH 88 (1998), 797-800; as well as the direct health affects, NS (6 June 1998), 22. Breast-fed infants of smoking mothers have ten times the level of urine cotinine level, AJPH 88 (1998), 893-6. It is difficult to stop retailers selling tobacco unless there is enforcement of laws, AJPH 88 (1998), 932-9. A study finding that tobacco legislators influence state legislative behaviour is AJPH 88 (1998), 918-23. On tobacco industry in Britain is also challenging government reports, BMJ 316 (1998), 1768. Cigar sales are steady despite falls in cigarettes, JAMA 279 (1998), 1513; but tobacco is exported, Lancet 351 (1998), 1597. A study of how people take doctor's advice to quit smoking is BMJ 316 (1998), 1878-81. A call to include smoking as a cause of death is made in BMJ 316 (1998), 1606-7. An Austrian company Austria Tabak has started to fund anti-smoking campaigns, Lancet 351 (1998), 1040. The US Minnesota tobacco suit was settled for US$6.5 billion on 7 May, Lancet 351 (1998), 1498. The US federal tobacco deal has been ended, BMJ 316 (1998), 1185; Newsweek (22 June 1998), 30-33; Time (29 June 1998), 42-4. A call for smokers to reap rewards of tobacco taxes is NS (11 April 1998), 3.

BRCA-mutation carriers are urged not to take up smoking due to high risk, Lancet 351 (1998), 1635; J. Natl. Cancer Inst. 90 (1998), 761-6. On the mechanism of nicotine addiction, NatMed 4 (1998), 659-60. On health damage, JAMA 279 (1998), 1715-9; BMJ 316 (1998), 1017, 1043-7; NS (30 May 1998), 5. Native American pipes have been found 3000 years old, Science News 153 (1998), 238. The combination of radon and smoking dramatically increases lung cancer deaths, and a US estimate suggests 12% of lung cancer cases are from radon, Science 279 (1998), 1311; BMJ 316 (1998), 1557. Methods to reduce exposure to indoor allergens are discussed in BMJ 316 (1998), 1075+.

Letters on mortality from alcohol include, NEJM 337 (1998), 1385; BMJ 316 (1998), 1515-7. The impact of alcohol dependency on liver transplantation policy is discussed in J. Rehabilitation (April-June 1998), 19+. Also see EJAIB 8 (1998), 105-111. A small amount of alcohol may make children attracted to alcohol, NS (7 March 1998), 12. Alcoholism in India is discussed in BMJ 316 (1998), 1394-5; and in the Western world in SA (June 1998), 80-5. The research into medical use of marijuana in the UK will be increased, BMJ 316 (1998), 1034-5, 1335; but WHO does not want to be involved, NS (21 Feb. 1998), 3-4, 24-31. There have been recent increases in student marijuana use in USA, AJPH 88 (1998), 887-92. On heroin and methadone treatment, MJA 168 (1998), 590-1, 596-600; BMJ 316 (1998), 1038, 1256-7. Mice that lack serotonin-1B receptor have increased susceptibility to cocaine, Nature 393 (1998), 118-9, 175-9. In general on illegal drugs, JAMA 279 (1998), 827-32.

A discussion of marijuana as medicine is in SA (August 1998), 18-9. It may alter cognitive functioning, NS (11 July 1998), 52; yet also protect the brain from damage after strokes, NS (11 July 1998), 16. Small changes in the A118G opiate receptor can make people more resistant to using opioid drugs, PNAS 95 (1998), 9608-12. Snorting cocaine leads to narrow arteries, NS (15 August 1998), 6. The UN is joining the campaign against illegal drugs, Lancet 351 (1998), 1863. A written questionnaire is being tested in UK schools to predict who will use drugs, NS (22 August 1998), 23. A call for doctors to be concerned about doping in sport is Lancet 352 (1998), 42, 415. A call for doctors to stop alcoholism is JAMA 279 (1998), 1767-8.

More information allows better public health measures but does make analysis complicated, AJPH 88 (1998), 1019-21; NEJM 339 (1998), 481-2. It is 150 years since the UK's first public health Act, Lancet 352 (1998), 251-2. Some diseases like cancer are very difficult to unravel however, NS (8 August 1998), 49. On clinical trials and use of data, Lancet 351 (1998), 1952-4; 352 (1998), 495-6; BMJ 317 (1998), 362-3. Patient preferences should be included when possible, BMJ 317 (1998), 78-9; SSM 47 (1998), 891-8. On patient information, BMJ 317 (1998), 264-5. Physicians may still be slow to implement the results of trials, such as the low prescription rate for diuretics, JAMA 279 (1998), 1813-6. The UK MRC was cleared of major misconduct in its radiation experiments in the 1950s and 1960s, but still the inquiry suggested more information could have been provided, NatMed 4 (1998), 752. A proposed radiotherapy trial in the UK also has ethical concerns, BMJ 317 (1998), 155-6.

The side effects of new drugs need to be informed more in many cases so that patients can choose, NEJM 338 (1998), 1844-6. Two trials of taxomifen on breast cancer found no effect, Lancet 352 (1998), 80-1, 93-7, 98-101; BMJ 317 (1998), 162. Bisphosphonates are discussed in NEJM 339 (1998), 398-400. A call has been made for more side effect studies on steriod drugs before they are used, Lancet 352 (1998), 461. Thalidomide is being approved for erythema nodosum leprosum, Lancet 352 (1998), 298. Also on thalidomide's new licensing, NatBio 16 (1998), 695. There are still concerns over Viagra, Lancet 352 (1998), 124; BMJ 317 (1998), 165. Letters on vitamin B6 10mg a day recommendation are in Lancet 352 (1998), 62-3; BMJ 317 (1998), 92-3, 370. On EU drug licensing policy and secrecy, Lancet 352 (1998), 480-2. Italy is stopping use of an unproven cancer treatment, the Di Bella cure, Nature 394 (1998), 514.

Methods for mapping genes that underlie ethnic variation in disease risk are reviewed in AJHG 63 (1998), 241-51. There are variations in cancer risk related to the genes we are born with, AJHG 63 (1998), 1-5; and racial factors may be involved beyond socio-economic trends, JAMA 279 (1998), 1801-7; 280 (1998), 356-62; Ophthalmology 105 (1998), 1135-6; BMJ 317 (1998), 164. A little bit of dirt is good for the immune system, NS (18 July 1998), 26-31. Discussion of suntan and melanoma is in Science News 153 (1998), 360-5.

Healthy food intake is discussed in Health Education Research 13 (1998), 1-12, 171-84; AJPH 88 (1998), 1216-8. The benefits of soybeans are discussed in Science News 153 (1998), 348-9. A US court has lifted an FDA ban of a dietary supplement called "natural" anticholesterol, Lancet 351 (1998), 1940. A debate of salt and high blood pressure is in Science 281 (1998), 933; NS (18 July 1998), 4. Education is also needed to make people aware of the warning signs of stroke, JAMA 280 (1998), 1288-92. Suicide rate is not affected by anorexia nervosa, AJPH 88 (1998), 1206-7. A trial found that orlistat can help reduce weight, Lancet 352 (1998), 167-73; an important goal for modern society, Lancet 352 (1998), 160-1. A paper on optimal body mass index and sexual attractiveness is Lancet 352 (1998), 548. Diet and cholesterol may not be so closely linked as assumed, NEJM 339 (1998), 12-20. Choices for obese patients are discussed in BMJ 317 (1998), 266-7.

On hormone replacement therapy and heart disease prevention, JAMA 280 (1998), 650-1. On the use of complementary medicines, MJA 169 (1998), 180-1. Gender bias and power is seen in Andean ethnomedicine, as in Western medicine, SSM 47 (1998), 1005-15. On occupational medicine, AJPH 88 (1998), 1012-3.

A review is Jacobson, N. "The socially constructed breast: Breast implants and the medical construction of need", AJPH 88 (1998), 1254-61. Letters on the risks of damage from implants include BMJ 317 (1998), 161, 230, 470-1; Lancet 352 (1998), 211, 380; Science 281 (1998), 511. A new UK study has found no increased risk of connective tissue damage from implants. In the Philippines many women want paler skin and are suffering from the chemicals used to bleach skin, Lancet 352 (1998), 555. On cosmetic treatment, JAMA 279 (1998), 1595-6.

There have been French and UK trials of feeding pesticides to people, who did not get sick after that, which may not be accepted by the US EPA, NS (8 August 1998), 13; BMJ 317 (1998), 430; Lancet 352 (1998), 499; Nature 394 (1998), 515. However pesticides may have impaired child development in an Arizona community, Science News 153 (1998), 358. A food borne outbreak is reported in BMJ 317 (1998), 268-8. Lead exposure damages the brain, and the damage is seen in children 20 years after exposure in Bunker Hill in the USA, Occup. Environ. Med. 55 (1998), 507-16. The lead levels in blood in the UK are 80% lower than 10-15 years ago, BMJ 317 (1998), 99.

A US study has found smoking doubles dementia and Alzheimer's disease risk, Lancet 351 (1998), 1840-3. Dopamine receptor genes may be related to ability to give up smoking, Lancet 352 (1998), 84-5. Smoking is more dangerous for black Americans, BMJ 317 (1998), 98. Letters on passive smoking and health damage are in BMJ 317 (1998), 301, 344-9; AJPH 88 (1998), 1011, 1025-9; JAMA 280 (1998), 32-33. On 14 August a US Federal Appeals Court said that the FDA did not have jurisdiction to make tobacco a drug, or monitor levels in the product. On the relationship between breast cancer, BRCA1 and tobacco, Science News 153 (1998), 325. A study of the way cigarette taxes influence sales is AJPH 88 (1998),1118-9. From 1991 to 1997 more US teenagers smoked, JAMA 280 (1998), 323-4, 1250-1; AJPH 88 (1998), 1193-8. Teenage girls start smoking to lose weight, BMJ 317 (1998), 366. Formula one sponsorship is one factor, Lancet 352 (1998), 205. A UK government report on smoking will be released to tobacco companies, NatMed 4 (1998), 872; Lancet 352 (1998), 7-8. South Africa is restricting smoking, Lancet 352 (1998), 465. The US is discussing various new tobacco bills, Lancet 351 (1998), 1869, 1941. The British Columbia government is requiring all components of cigarettes to be displayed, BMJ 317 (1998), 101. Nicotine withdrawal may be related to accident rates, Nature 394 (1998), 137.

Methods to reduce violence are being discussed as more school age acts are seen in USA, SA (Sept. 1998), 15-6. One factor there is the availability of guns, JAMA 280 (1998), 403-7, 423-7, 439-42, 471-5; NEJM 339 (1998), 565-6. The Dutch government is studying brains of boxers for damage, BMJ 317 (1998), 370. The safety of chemical police CS sprays is being questioned and an editorial called for a moratorium on their use, Lancet 352 (1998), 159. A call for doctors to be involved in suicide prevention is BMJ 317 (1998), 156-7; and in domestic violence prevention, BMJ 317 (1998), 99. Antidepressant drugs may be usually little better than placebos, NS (11 July 1998), 3, 13. A book review of The Placebo Effect is Lancet 351 (1998), 1895. A placebo needle is being added to trials of acupuncture research, Lancet 352 (1998), 364-5. There are adverse health effects of job insecurity, AJPH 88 (1998), 1030-6.

An EPA panel has concluded that EMF may be carcinogenic, BMJ 317 (1998), 12; Science 281 (1998), 21-2. Resting blood pressure increases during exposure to radio-frequency electromagnetic fields, Lancet 351 (1998), 1857-8. EMF dangers from mobile phones are discussed in Lancet 352 (1998), 576-7. Some unexplained forest fires may be caused by power line sparks, NS (25 July 1998), 20.

The seas around the UK are expected to stay radioactive for a long time, NS (1 August 1998), 22. There are high risks of damage being caused by accidents at Sellafield, Lancet 352 (1998), 44. A US project to collect babies teeth to measure radioisotope strontium-90 in the teeth is called the Tooth Fairy Project, see <www.radiation.org>. Scientists have been attempting to slow the nuclear arms race between India and Pakistan, JAMA 280 (1998), 467; Science 281 (1998), 494-5; JAMA 280 (1998), 456-61. Attempts to reduce dangers of plutonium are discussed in Nature 394 (1998), 415-6.

A review of cholesterol-lowering plant oil products is in GEN (15 Sept. 1998), 1, 14, 18. Tamoxifen can be sold in the USA but not with a claim for prevention of breast cancer, but for reducing short-term incidence of breast cancer in women at increased risk, Lancet 352 (1998), 883; BMJ 317 (1998), 697; Science News 154 (1998), 166. Viagra continues to receive much attention, and is being marketed on the Internet, Lancet 352 (1998), 751. A review of the situation in different countries is BMJ 317 (1998), 836-8. Also see JAMA 280 (1998), 119-20, 867+; BMJ 317 (1998), 759-61, 824. Benzodiazepines may reduce driver safety, Lancet 352 (1998), 1324-5, 1331-6.

Many Japanese pharmaceutical companies are carrying out clinical trials of new drugs in Europe rather than in Japan, to avoid regulations and expense, Japan External Trade Organization (JETRO; Tokyo). JETRO surveyed 64 Japanese drug companies, NatBio16 (1998), 898-9. A report on clinical trials on children in Canada is discussed in NatMed 4 (1998), 1095. Children are not just small adults, Lancet 352 (1998), 630. See also, Lancet 352 (1998), 590-1. On the European Medicines Evaluation Agency, BMJ 317 (1998), 898; and FDA, BMJ 317 (1998), 899; Nature 395 (1998), 4; JAMA 280 (1998), 187-193. Placebos are discussed in JAMA 280 (1998), 751-2; BMJ 317 (1998), 875-80.

There is accumulating evidence that transplacental exposure to cigarette smoke causes genetic damage in utero, NatMed 4 (1998), 1119-20; BMJ 317 (1998), 903 (see Fetal Environment section). The relationship between women's magazines and tobacco suggests another area for regulation, Lancet 352 (1998), 786-7. A survey in Switzerland has calculated that the annual cost of smoking per person is US$6.5 to the country, Lancet 352 (1998), 797. There has been a tobacco deal in the USA with several states and companies for compensation to the costs caused Also on US tobacco control, JAMA 280 (1998), 1173-81; 1279+. Israel has filed a suit against tobacco companies, BMJ 317 (1998), 968. Smoking can have a direct role in strokes, BMJ 317 (1998), 962-3; and on the risk of Alzheimer's disease, Lancet 352 (1998), 818-9; and hearing loss, JAMA 280 (1998), 963-5. There are differences between people and perhaps race also, JAMA 280 (1998), 152-6. A book review of For Your Own Good, a defense of smoking is Lancet 352 (1998), 745-7. A review of a Californian researchers dismissal from a contract after results were not positive for the state control program (JAMA 280 (1998), 893-9) is discussed in Nature 395 (1998), 629. Smoking cessation plans are evaluated in NEJM 339 (1998), 673-9.

The U-shaped relation for alcohol and health is discussed in Lancet 352 (1998), 877. There is still lack of clear evidence for linking specific beverages to cancers, BMJ 317 (1998), 827, 844-8; JAMA 280 (1998), 1138-9. Also on alcohol studies, JAMA 280 (1998), 166-71. Votes on medical marijuana were conducted in various US states. Some illegal drugs are being made from legal precursors, Lancet 352 (1998), 1045. Herbal medicines are going to be more tightly regulated, NS (24 Oct. 1998), 53; NEJM 337 (1998), 785-91, 839-41.

Prevention of occupational mental diseases are discussed in Lancet 352 (1998), 999; also pp. 1213-5. Long hours do increase risk of heart disease in Japan, BMJ 317 (1998), 775-80. Flight attendants may have some increased risk of breast cancer, Lancet 352 (1998), 626. The US congress has required health plans to pay for breast reconstruction, Lancet 352 (1998), 1453. On performance enhancers, BMJ 317 (1998), 702.

On food, leptin, and diet, Lancet 352 (1998), 712, 756-7; NatMed 4 (1998), 983, 1189+; BMJ 317 (1998), 553-4, 835, 1069-71; Nature 395 (1998), 231-2, 454, 763-70; NEJM 337 (1998), 719-24, 765-6, 856-7; JAMA 280 (1998), 869. On selenium may be linked to lower risk of prostrate cancer, Lancet 352 (1998), 713, 755-6. Methylmercury exposure has neurotoxicity, JAMA 280 (1998), 701-7, 737-8. A series of papers on ethics of epidemiology are in SSM 47 (1998), 1133-230+. On public health in general, Lancet 352 (1998), 903-4; BMJ 317 (1998), 549-52, 584-6; JAMA 280 (1998), 196. Prevention of lead poisoning is discussed in Science 281 (1998), 1617-8. Life expectancy in Europe has fallen, BMJ 317 (1998), 767. On firearm policy, NEJM 337 (1998), 813-8.

A report from the Netherlands Health Council on toxic substances in the workplace is reviewed in Network 13 (Dec 1998), 5-7. Landfill sites may be associated with congenital abnormalities sometimes, Lancet 352 (1998), 1705. Chemical exposures are also discussed in the Environment section above, see also JAMA 280 (1998), 1797-8; Lancet 352 (1998), 1945; AJPH 88 (1998), 1759-60. Patients from sheep dip exposure will be treated more carefully, BMJ 317 (1998), 1339; NS (14 Nov. 1998), 14. Flying foxes in Queensland are developing abnormalities, NS (21 Nov. 1998), 15. On lead levels in an urban setting in children, AJPH 88 (1998), 1837-9, 1871-7; JAMA 280 (1998), 1915-9; and children next to a battery factory were also at risk of lead poisoning, AJPH 88 (1998), 1843-5. Lead may be found in game birds, NS (2 Jan. 1999), 14. Occupational medicine is discussed in JAMA 280 (1998), 1795-6; and on the dangers of living near a steel factory, Occupational & Environmental Medicine 55 (1998), 812-22. The dangers of children exposed to traffic accidents are discussed in AJPH 88 (1998), 1840-5; and on stress disorder in victims, BMJ 317 (1998), 1619-23; and on air pollution from traffic and health in children, Occupational & Environmental Medicine 55 (1998), 771-8. Airbag safety is being improved, Science News 154 (1998), 206-7.

Moderate alcohol consumption reduces risk of myocardial infarction, Lancet 352 (1998), 1882-5. Ethanol consumption and resistance are inversely related to neuropeptide Y levels, Nature 396 (1998), 366-9. A cannabinoid dexanabinol (HU-211) may protect against head trauma, Lancet 352 (1998), 1529. Cocaine reward is regulated by a transcription factor CREB, Science 282 (1998), 2273-5. Addiction is a brain disease, Amer. J. Psychiatry 155 (1998), 711-3. On drugs that alter the mind, JAMA 280 (1998), 1873; Lancet 352 (1998), 1697-9; and welfare dependency, AJPH 88 (1998), 1616-22; MJA 169 (1998), 356-9, 404-5; and race and class factors, Columbia Law Review 98 (1998), 1795-842. On stress in farming, Occupational & Environmental Medicine 55 (1998), 729-34. Doping in sport is discussed in Lancet 352 (1998), 1781-2. A US panel has called for reexamination of the drug Ritalin used to treat attention deficit hyperactivity disorder in children, BMJ 317 (1998), 1545; NS (28 Nov. 1998), 3. A review of psychopathology in children is Amer. J. Psychiatry 155 (1998), 715-25.

Cardiovascular disease is increasing in China, NatMed 4 (1998), 1209-10; Lancet 352 (1998), 1795. Antioxidants may also help in Crete, Lancet 352 (1998), 1987-8; and nuts, BMJ 317 (1998), 1332-3, 1341-5; Science News 154 (1998), 328-9. On cholesterol destroying drugs, Science News 154 (1998), 311. In East Asia blood pressure is a stronger link to stroke than in Western countries, Lancet 352 (1998), 1801-7. On drinking and driving, Lancet 352 (1998), 1871. Methods to change behaviour are required for all health advice, NS (28 Nov. 1998), 53. Diet and cancer is discussed in Lancet 352 (1998), 1789-90; BMJ 317 (1998), 1331-2, 1636-40; Newsweek (30 Nov. 1998), 42-8. Exercise is good medicine, Lancet 352 (1998), 1999-2000; NEJM 339 (1998), 1552-3.

A gene has been found that is associated with appetite, and the peptides are called orexins. Chromosome 10 appears to have some obesity-related genes, NatGen 20 (1998), 304-8; also Clinical Genetics 54 (1998), 385-895. On obesity mechanisms, BMJ 317 (1998), 1607-8. Food labels are being used by 43% of women and 27% of men in a US study, FDA Consumer (Nov. 1998)., 4. Not all the claims of foods are truthful however, FDA Consumer (Nov. 1998), 16-21. Low calorie diets may slow monkey aging, Science 282 (1998), 1018. Until now, red wine has been the cardioprotective beverage of choice, but the convenience and lack of adverse effects make beer a more cost-effective, safe and widely available choice, CMAJ 159 (1998), 1463-6.

Two studies suggest one third of Chinese men will die from tobacco-related deaths, BMJ 317 (1998), 1399-40, 1411-24; Lancet 352 (1998), 1683; NS (28 Nov. 1998), 18-9. There was also a UK government report, called "Smoking kills", Lancet 352 (1998), 1991; and there are calls to mention smoking as a cause of death on death certificates, BMJ 317 (1998), 1456. A letter calling it an ethical obligation to advise patients to quit smoking is BMJ 317 (1998), 1588. Doctors have also called for the level of nicotine to be reduced to non-addictive levels, BMJ 317 (1998), 1271. Nicotine replacement therapy should be covered by health systems, BMJ 317 (1998), 1266-7. Another drug may reduce nicotine craving, called gamma vinyl-GABA; Science 282 (1998), 1797-8; Synapse (Jan. 1999).

The price of a pack of cigarettes in the USA has risen by 50 cents following the deal on a US$206 billion settlement with 46 states, Lancet 352 (1998), 1765, 1839. In the UK some cancer patients are sueing companies, BMJ 317 (1998), 1614. In 1998 tobacco companies had to open about 30 million pages of closed documents, which revealed many secrets on strategies, NS (2 Jan. 1999), 30-1. US students are smoking more cigarettes, JAMA 280 (1998), 1673-8; BMJ 317 (1998), 1405. Community efforts may be needed, AJPH 88 (1998), 1658-63. The WHO has issued Guidelines for Controlling and Monitoring the Tobacco Epidemic (WHO, 1998, 200pp. ISBN 92-4-154508-9). On smoking and tax, BMJ 317 (1998), 1339. South Africa has banned advertising of tobacco, Lancet 352 (1998), 1609. Tobacco laws are discussed in AJPH 88 (1998), 1606-7. Nonsmoking restaurants are still associated with cooking emissions, AJPH 88 (1998), 1834-6; but still health of workers has improved, JAMA 280 (1998), 1909-14. A study of smoking and DNA adduct levels is FASEB J. 12 (1998), 1409-17. Identifying people at risk is a challenge, JAMA 280 (1998), 1947-9.

A review of trends in alternative medicine use in the USA is JAMA 280 (1998), 1554-6, 1569-75, 1616-7, 1626-8, 1635; Science 282 (1998), 2175-6; BMJ 317 (1998), 1270. The ethical obligations of providing alternative medicines are discussed in JAMA 280 (1998), 1623-5. Acupuncture has been accepted in USA for some therapies, Lancet 352 (1998), siv1. Phytooestrogens are very popular, Lancet 352 (1998), 1762. Adverse effects of cannibis are discussed in Lancet 352 (1998), 1565, 1610-6; BMJ 317 (1998), 1394; while some medical trials continue, Nature 396 (1998), 206; NS (14 Nov. 1998), 3. Genetic factors may determine if someone will be a heavy user, Amer. J. Psychiatry 155 (1998), 1016-22. Herbal plants also have implications for the biotech industry, GEN (1 Nov. 1998), 1, 10, 26, 40. Though one of the supporters of herbals has said that none is as safe or effective as standard drugs, Probe VII (No. 2, Dec 1998), 1, 8. Chinese herbal medicine may help irritable bowel syndrome however, JAMA 280 (1998), 1585-9; Lancet 352 (1998), 1605. Some supplements are associated with disease, FDA Consumer (Sept. 1998), 34-5. Aspirin is being recommended for heart disease and stroke by the FDA, BMJ 317 (1998), 1176. On FDA regulation, Science 282 (1998), 1263. A FDA-style agency may be developed after reforms in Japan, NatBio 17 (1999), 7.

On clinical trials: Studdert, DM. & Brennan, TA. "Clinical trials in developing countries: scientific and ethical issues", MJA 169 (1998), 545-8; Edwards, SJL et al. "The ethics of randomized controlled trials from the perspectives of patients, the public, and healthcare professionals", BMJ 317 (1998), 1209-12. Tsutani, K. "General view of clinical trials and GCP in East Asia", Drug Information J. 31 (1997), 1057-64; Lancet 352 (1998), 1217-20, 1243-5, 1767-70; BMJ 317 (1998), 1170-2, 1177-80, 1191-2000. Adverse reactions to drugs can be reported by Email, mail or fax, FDA Consumer (Nov 1998), 7-9. Internet marketing can be dangerous, and it is possible to buy human male/female pheromone attractants, and they are advertised on the Internet, <http://www.angelfire. com/fl/beaches69/index.html>.

Dow Corning has released details of the proposed breast-implant settlement, which sets up a US$3.2 billion fund for 170,000 women involved in injury claims, Lancet 352 (1998), 1688. At the same time a scientific panel has suggested that only a few cases of the diseases would be caused by the implants, Science 282 (1998), 1963, 1965. Public health is general is discussed in Public Health 112 (1998), 283-5. A group of 13 Barcelona doctors have been charged with fraud for claiming more expensive drug costs from the government than they paid, BMJ 317 (1998), 1616. The question why patients do not take their pills for hypertension is debated in CMAJ 160 (1999), 64-5.

A consistent risk of EMF fields and childhood leukemia is reported in AJPH 88 (1998), 1787-94. People are trying to combat noise pollution from cell phones with radiofrequency emitters that jam the signals, promoting more pollution of the radiowaves, NS (12 Dec. 1998), 6. On health risks of radiation, Nature 396 (1998), 402. The Yucca mountain depository is reviewed in Nature 396 (1998), 497, 500. There are fears of an accident at the UK nuclear waste repositories, NS (2 Jan. 1999), 7. Nuclear safety standards should also protect plants and animals, NS (12 Dec. 1998), 27. A plant that goes blue when radiated has been developed, NS (28 Nov. 1998), 22. Cells that escape a direct hit from radiation are still altered by it, NS (5 Dec. 1998), 22. Scottish sheep farms are still contaminated with Chernobyl fallout, NS (21 Nov. 1998), 12.

On drug approval in Europe, NatBio 17 (1999), 237-40. There is concern that a number of drugs used on children have only been tested on adults, BMJ 318 (1999), 554; NS (20 Feb. 1999), 18-9. On drug-testing for cancer, SA (Feb 1999), 19, 22. The needs for postmarketing surveillance are discussed in JAMA 281 (1999), 824-29; 830, 841. The question of testing poisons on human volunteers is being debated by the EPA, Science 283 (1999), 18-9. A fluorescent jellyfish gene is being used as a marker for carcinogens, NS (20 Feb. 1999), 7. A review of Prozac Diary is Lancet 353 (1999), 155-6. On psychological stress among international business travelers, Occup. Environ. Med. 56 (1999), 245-52.

A book review of Salt, Diet and Health is Lancet 353 (1999), 597-8. Papers on salt include MJA 170 (1999), 174-9. On coronary disease risks, AJPH 89 (1999), 379-82; JAMA 281 (1999), 1291-7. One risk factor is depressive illness, BMJ 318 (1999), 826; another is poor prenatal nutrition, BMJ 318 (1999), 427-31. There is concern that statins may not be prescribed for the people who rely need them, BMJ 318 (1999), 827. A paper on platelets and wine ethanol is Lancet 353 (1999), 1067. Angiogenesis is inhibited by drinking tea, Nature 398 (1999), 381. A US report has recommended the use of marijuana for some pain control, but this has been rejected, Lancet 353 (1999), 1077; NS (27 March 1999), 14. Early infection, e.g. through nursery contact, may protect against allergies in later life, Lancet 352 (1998), 450-4.

Increased grain intake reduces mortality, AJPH 89 (1999), 322-9. On antioxidant vitamins, AJPH 89 (1999), 289-91; and vitamin A and B, BMJ 318 (1999), 551-2. There are safe limits to consumption but they are not well defined, NS (27 Feb. 1999), 18-9. On fat intake, FDA Consumer (Jan 1999), 23-7. Frequent dieting can expose people to toxic chemicals, NS (30 Jan. 1999), 13. Overcooking of meat results in increased breast cancer risk, Science News 154 (1998), 341; and on meat and cancer, Lancet 353 (1999), 686-7. Endostatin has been confirmed as a tumour shrinker, Nature 397 (1999), 597. On exercise, JAMA 281 (1999), 327-34, 335-40, 375. A special report WHO Technical Series 883, titled Food Safety Issues Associated with products from Aquaculture 50pp., has been released (WHO 1999). On sprouts and food safety, FDA Consumer (Jan 1999), 18-22.

On occupational safety, BMJ 318 (1999), 1015; Occup. Environ. Med. 56 (1999), 145-51; MJA 170 (1999), 150-1. An unlicensed ingredient of the vaccine mix may have caused Gulf War syndrome, NS (10 April 1999), 5; BMJ 318 (1999), 274-5; Lancet 353 (1999), 169-78, 179-82. In general on public health, JAMA 281 (1999), 1030-3; and promoting children's health, AJPH 89 (1999), 155-7. Giving food cooked in iron pots can help reduce iron deficiency, Lancet 353 (1999), 712-6, 690. The benefits of hand washing are great for health care workers, BMJ 318 (1999), 686. A call for increased health literacy is JAMA 281 (1999), 552-7.

A survey of EMF from cellular telephone repeaters is Thansandote, A. et al. "Radiofrequency radiation in five Vancouver schools: exposure standards not exceeded", CMAJ 160 (1999), 1311-2, 1318-9; and on the growing fear, NS (10 April 1999), 3. Russian research has identified a number of potential hazards to food safety caused by microwave ovens, ENDS (1 Nov. 1999), 24; Environment & Health News 12 (March 1999), 9-10. A small study finding no link between EMF and fertility is Occup. Environ. Med. 56 (1999), 253-5; however a study has found men who worked in the presence of strong EMF fields may have 3 times higher heart disease risk, Science News 155 (1999), 70; Amer. J. Epidemiology (15 Jan. 1999). On radon and lung cancer, AJPH 89 (1999), 351-7. On mobile phones, NS (27 Feb. 1999), 20-5.

The use of depleted uranium as a hardener for military vehicle armour and for bullets has led to growing concerns on the exposure of persons to the radiation from it, Environment & Health News 12 (March 1999), 1. The health affects on nuclear test veterans are still being addressed in the UK and Australia, Lancet 353 (1999), 299. Nuclear waste storage is discussed in NS (16 Jan. 1999), 12, 30-33; (27 March 1999), 3, 22-3; Science 283 (1999), 158-9, 1626-7; Nature 398 (1999), 271, 357, 645. On recovery from Chernobyl accident, NS (10 April 1999), 7.

Papers on silicone breast implants and health are AJPH 89 (1999), 483, 484-9; BMJ 318 (1999), 414; Bernstein, DE. "The breast implant fiasco", California Law Review 87 (1999), 457-510. Implants containing soy oil have been withdrawn in the UK, Lancet 353 (1999), 903. On cosmetic surgery, BMJ 318 (1999), 512-6. The American Academy of Pediatrics has concluded that circumcision is not to be routinely recommend, JAMA 281 (1999), 1075.

A paper finding that smoking is associated with poorer mental health and calling for careful cessation to restore health is MJA 170 (1999), 74-7. On anti-smoking campaigns, AJPH 89 (1999), 346-50; Lancet 353 (1999), 388, 909; BMJ 318 (1999), 892; NEJM 340 (1999), 572-3. Tobacco and alcohol use is found in two thirds of G-rated children animated films, JAMA 281 (1999), 1131-6. On the long history of a tobacco industry public relations journalist, Probe 7 (1 April 1999), 1, 3-7. The industry had methods to reduce risks to health but did not use them, NS (6 March 1999), 3, 4-5. In general on risks, NatMed 5 (1999), 15-7; Bulletin WHO 77 (1999), 82-3; NEJM 340 (1999), 920-6, 958-9; JAMA 281 (1999), 1019-21; BMJ 318 (1999), 891. On drug addiction, Nature 398 (1999), 567-70; heroin addiction, MJA 170 (1999), 129-30; and nicotine addiction, NS (16 Jan. 1999), 3. The prevalence of smoking among pregnant women is lower in Italy than in England, BMJ 318 (1999), 1012. A terminally ill patient was awarded US$50 million in damages against Philip Morris company, who have said they will appeal, BMJ 318 (1999), 481. Some cancer centers are trying to obtain money from the US tobacco settlement, NatMed 5 (1999), 10. On the question of whether tobacco money should be used for research, NatMed 5 (1999), 125, 129.

The European Commission's Scientific Committee on Veterinary Measures released a report on 3 may claiming that 17B-oestradiol is a carcinogen, thus justifying the EC ban on imports of hormone-treated beef from the USA, before the 13 May deadline of the World Trade Organization for the EC to lift its ban, Nature 399 (1999), 8; Lancet 353 (1999), 1864. The consequences for food safety from the use of fluoroquinolones in food animals is reviewed in NEJM 340 (1999), 1581-8. On food-borne illness, JAMA 281 (1999), 1845-7.

The FDA regulations on financial disclosure by clinical investigators are discussed in BME 147 (1999), 9-11. A review of the ten great achievements of public health in the USA this century is JAMA 281 (1999), 1481.

On the placebo effect, Nature 399 (1999), 427. Thalidomide is being reintroduced to medicine, NatMed 5 (1999), 489-90. On the use of alternative medicine, NEJM 340 (1999), 1758-9; JAMA 281 (1999), 1698-9; and safety of medicines, JAMA 281 (1999), 1753-4.

A paper on heroin trials in Australia is Pike, GK. "Heroin trials - no easy fix", Bioethics Research Notes 11 (1999), 1-4; JAMA 281 (1999), 1782-3. Also on drug policy, Science 284 (1999), 1277-8; Issues in Science & Technology 14 (1998), 45-52, 53-60; NS (29 May 1999), 7; Lancet 353 (1999), 1449-50; BMJ 318 (1999), 1300-1. Research to make tobacco less harmful is suggested in NS (May 1999), 18-9; and against smoking, Bulletin WHO 77 (1999), 367; NS (29 May 1999), 15, 18-9; AJPH 89 (1999), 691-8; JAMA 281 (1999), 1849+. On alcohol use, BMJ 318 (1999), 1311-6; AJPH 89 (1999), 678-84, 685-90; Lancet 353 (1999), 1448. Smoke-free ordinances in restaurants may increase patronage in a US study, JAMA 281 (1999), 1911-8.

An egg a day may not harm health, JAMA 281 (1999), 1387-94; BMJ 318 (1999), 1094. Also on diet and health, BMJ 318 (1999), 1418-9; NEJM 340 (1999), 1770-2; Science News 155 (1999), 181; Lancet 353 (1999), 1458-9, 1540-1, 1547-57. NIH recommendations for vitamin C intake of 100-200 mg/day is suggested in JAMA 281 (1999), 1415-23, 1460. A series of papers on antioxidant action are in FASEB J. 13 (1999), 963-1106.

More reports from silicone breast implant safety trials are reviewed in Lancet 353 (1999), 1455, 1506. The question of whether cellphones cause cancer is discussed in NS (29 May 1999), 5. Limited vitamin D intake and sunscreens may lead to rickets in some cases, BMJ 318 (1999), 1417. On guns and death, BMJ 318 (1999), 1160-1.

A study from South America has found four types of craniofacial defects were more common in higher altitude and two types of neural tube defects were lower, Castilla, EE. Et al. "Altitude as a risk factor for congenital anomalies", AJMG 86 (1999), 9-14.

A review of orphan drug law is in FDA Consumer (May-June 1999), 29+. The role of courts in health technology assessment is discussed in Science 285 (1999), 203-4. Online pharmacies are still striving for respectability, Lancet 354 (1999), 782. Japan is attempting to increase the number of clinical trials, NatMed 5 (1998), 860. Prescribing medicine for children remains difficult, BMJ 319 (1999), 70-1. A report from Japan (in Japanese) is Tsutani, K. & Shimizu, N., eds., Evidence of Off-Label Use of Drug, Clinical Evaluation Vol. 26 (1999), Supplement No. XIII, 334pp., ISBN 4-925066-01-3, Y5000). Pharmacotherapy for children with intellectual disability is reviewed in Lancet 354 (1999), 231-40. On problems of randomization using sealed envelopes, Lancet 354 (1999), 73-4. On evidence-based medicine, MJA 170 (1999), 465-6. Reducing adverse drug reactions requires cooperation between all groups, JAMA 282 (1999), 315-6. Noncompliance may be a cause of half of the antihypertensive drug failues, JAMA 282 (1999), 313-4.

An historical account of debate on foreign drugs is Lancet 354 (1999), 149-51. A study of donated drugs to Kosovo found 40% were non-essential and 30% were close to expiry dates, Lancet 353 (1999), 2131. A museum review of Illegal Drugs in America is Lancet 354 (1999), 604; and opium in BMJ 319 (1999), 131. Questions on the use of drug tests at work are in NS (24 July 1999), 18-9. Nuns at St. Vincent's Hospital in Sydney are going to run Australia's first legal heroin injecting room, BMJ 319 (1999), 400. More means to prevent cocaine addiction may be developed, Nature 399 (1999), 371-5. The US is making research marijuana more accessible, NatMed 5 (1998), 721. There is an increase in deaths in the USA on the first week of the month which is associated with substance abuse, NEJM 341 (1999), 93-8. On abuse of drugs for sport, MJA 171 (1999), 206-8. The life expectancy in Russia for men has now fallen to 58 years, from 62 years in 1980, BMJ 319 (1999), 468.

Chinese medicine is discussed in Lancet 354 (1999), 493; BMJ 319 (1999), 160-1. In the USA the following popular drugs are being tested for safety, aloe vera, ginseng, kava and milk thistle. On the use of alternative medicine, NEJM 340 (1999), 1758-9, 1845; Nature 400 (1999), 729. A review of social factors in the taxol drug is Walsh, V. & Goodman, J. gCancer chemotherpay, biodiversity, public and private property: the case of the anti-cancer drug Taxolh, SSM 49 (1999), 1215-25. Overuse of androstenedione is discussed in JAMA 281 (1999), 2043-4, 2020+. On public health and injecting drug use, Lancet 354 (1999), 65-8.

Individual susceptibility to pesticides may be the best way to assess risks, Occup Environ. Med. 56 (1999), 449-53. Prolonged exposure to sheep-dip is a health risk, Lancet 354 (1999), 133. Illnesses associated with occupational use of flea control agents are discussed in JAMA 282 (1999), 125-6. A book review of Black Lung, which looks at coal-mine related death is NEJM 340 (1999), 1770.

A study showing recent Russian immigrants to Israel drink more than Israelis is AJPH 89 (1999), 1212-6. Ethnic groups in the US vary widely in child health, AJPH 89 (1999), 1066-71. Overnight wearing of contact lenses is a health risk, Lancet 354 (1999), 174-5, 181-5.

A survey of epidemiology articles found 24% included policy recommendations, AJPH 89 (1999), 1206-11; on epidemiology in laws, Lancet 353 (1999), 2238-9; and on the role of epidemiology in public health, AJPH 89 (1999), 1151-55, 1158-61. Health promotion using entertainment television is one strategy that has been used following the successful US TV program, ER, AJPH 89 (1999), 116-7. A book review on education methods is SSM 49 (1999), 705-8. The UK has launched a public health campaign that hopes to prevent 300,000 deaths over 10 years, Lancet 354 (1999), 139; BMJ 319 (1999), 73, 139-40.

Although once a year is a reasonable frequnecy to go to the dentist, rates of disease progression vary widely, BMJ 319 (1999), 204-5. HIV-positive women tend to use dentists less, AJPH 89 (1999), 834-9.

A review is Hemingway, H. & Marmot, M. gPsychological factors in the aetiology and prognosis of coronary heart disease: systematic review of propective cohort studiesh, BMJ 318 (1999), 1460-7. A study found 41% of deaths in Australia in 1997 were cardiovascular, MJA 170 (1999), 408-9. Women tend to have heart disease at older age than men, Lancet 354 (1999),401. On socioeconomic environment and disease in general, AJPH 89 (1999), 1059-65; JAMA 282 (1999), 130-1. Homocysteine and vascular disease is discussed in Lancet 354 (1999), 407-13. Low dose aspirin is useful for preventing strokes, Lancet 354 (1999), 2172-3, 2179+. The drug spironolactone has been found to be useful for treating heart disease patients, BMJ 319 (1999), 276; see also BMJ 318 (1999), 1499-500.

On vitamin B12, MJA 170 (1999), 407-8. Letters discussing how alcohol affects health are Lancet 354 (1999), 513-4; Bulletin WHO 77 (1999), 611. There may be some benefits for mild drinking among diabetics also, JAMA 282 (1999), 239-46, 279-80; Lancet 354 (1999), 311. Recommendations for exercise should be made also, BMJ 319 (1999), 334; including brisk walking, NEJM 341 (1999), 650-8.

A review by the US Institute of Medicine has found no link between silicone breast implants and serious autoimmune diseases, that are included in legal actions, but there are some problems; JAMA 282 (1999), 314-5; Lancet 353 (1999), 2215; SA (Sept. 1999), 18; Science 284 (1999), 2065; BMJ 319 (1999), 8. A Swedish working population survey has looked at occupations with excess risks of breast cancer, AJPH 89 (1999), 875-81. From 1988-1993 there was an increase in breast-conserving surgery, JAMA 282 (1999), 326. On use of taxomifen for prevention in health women at risk of breast cancer, JAMA 282 (1999), 117-8; Lancet 353 (1999), 1986-7, 1993-2000.

Violence is discussed in MJA 170 (1999), 352-3; JAMA 282 (1999), 135-6, 425-6, 440-6, 475-6; BMJ 319 (1999), 395, 407-10. In the US in 1994 gunshot injuries cost about US$2.3 billion in lifetime medical costs, JAMA 282 (1999), 447-54. A report on firearm use in G and PG movies is JAMA 282 (1999), 428. A call for prevention of conflict is made in BMJ 319 (1999), 396-7. A US study of an antiviolence drug among prison teenagers has been challenged as breaking rules on research, Science 285 (1999), 1337-8. Child abuse is generally underrated as a source of child mortality in the USA, JAMA 282 (1999), 463-7. A call for more childseat use is in JAMA 281 (1999), 2070-2.

Debate over a safe dose of radiation is in Lancet 354 (1999), 400; Science 285 (1999), 177. Thyroid cancers have increased tenfold among Ukrainian children since the 1986 Chernobyl accident, Lancet 354 (1999), 51; BMJ 319 (1999), 145. Chernobyl cesium radioactivity is persisting in fish much longer than predicted, so its biological half life is long, Nature 400 (1999), 417. On risks of radiation for future children, Occup. Environ. Med. 56 (1999), 438-442; BMJ 319 (1999), 1443-50. Pigeons at Sellafield in the UK have been roosting in contaminated buildings with the result that they and their droppings are radioactive, NS (14 August 1999), 48-9. Depleted uranium weapons used by NATO soldiers may be contaminating the environment, NS (5 June 1999), 20-1. Radon is discussed in AJPH 89 (1999), 933-5. On the methodology to estimate EMF radiation effects on health, Occup. Environ. Med. 56 (1999), 562-6. Any link to leukemia is weak, BMJ 319 (1999), 10; Lancet 353 (1999), 2217; Science 285 (1999), 337.

A review is Sato, H. gPolicy and politics of smoking control in Japanh, SSM 48 (1999), 581-600. Cigars also affect health negatively, NEJM 340 (1999), 1773-80, 1829-31. On efforts to stop sales of cigarettes, BMJ 318 (1999), 1508; 319 (1999), 524. Smoking is a major cause of blindness may be added to cigarette packs, MJA 171 (1999), 173-4. Passive smoking also increases risk of acute stroke, Lancet 354 (1999), 653; and heart disease, NEJM 341 (1999), 697-9. Methods to reduce passive smoking by asthmatic children were found to require cessation by the parents to be effective, BMJ 318 (1999), 1456-9. Passive smoking debates are discussed in a historical perspective in SSM 49 (1999), 1183-95. On health impact of smoking, SSM 48 (1999), 1851-6; and on lungs after cessation, Lancet 354 (1999), 177-8. Genetic polymorphism at CYP2A6 and linkage to smoking is discussed in Lancet 354 (1999), 2073. A Florida court has found tobacco companies guilty of fraud, BMJ 319 (1999), 143; Lancet 354 (1999), 231. Rio de Janeiro is making a law suit against health care losses from smoking, Lancet 354 (1999), 315. On Chinese smoking expansion, BMJ 318 (1999), 1554-5.

Tobacco control is discussed in JAMA 282 (1999), 424; BMJ 318 (199), 1437; 319 (1999), 266; NatMed 5 (1999), 851. The World Bank has evaluated the economics of tobacco control and smoking, NatMed 5 (1999), 596. Depression and smoking decreases the immune system, Science News 155 (1999), 358.

A summary of medicinal plant and food use from a culinary competition in India is Honey Bee 10 (No. 3, July-Sept. 1999), 3-4. Complementary medicine is discussed in Bioethics Examiner 3 (Fall 1999), 1-2; Probe 8 (Dec. 1999), 1, 4-5; Issues in Medical Ethics 7 (Dec. 1999), 109-112. The trial of so-called SouthAfrica7s Dr. Death is discussed in Newsweek (18 Oct. 1999), 35. The issue of heroin injecting rooms in Catholic Health care Services is discussed in Bioethics Research Notes 11 (Sept. 1999), 1-2. Debate continues on the use of tamoxifen, Lancet 354 (1999), 841, 1007. A book review of The Elusive Magic Bullet: The Search for the Perfect Drug is NEJM 341 (1999), 1320-1. On testing of healthcare, BMJ 319 (1999), 652-3. The decision to stop the PETACC-1 clinical trial is discussed in Lancet 354 (1999), 1045.

Some two year olds are even prescribed behaviour changing drugs now, NS (6 Nov. 1999), 17. Direct to consumer drug advertising is a billion dollar business in the USA, BMJ 319 (1999), 591, 805, 1208. There have been accusations that DrKoop.comfs web site is advertising, BMJ 319 (1999), 727. Education of health practioners in the UK had a positive impact on educating old persons, BMJ 319 (1999), 683-7; and educating in general, BMJ 319 (1999), 943-8. A too clean life may not be good for the immune system, Science News 156 (1999), 108-10. There have been calls foir better dioxin testing in Europe, Lancet 354 (1999), 1276. On the use of thalidomide as an anticancer drug, Lancet 354 (1999), 925, 1705; NEJM 341 (1999), 1606-9.

The use of tissue culture systems for toxicity testing is reviewed in BIOforum International 3 (2/99), 70-3. There is controversy over the pesticide chlorfenapyr in the USA for its possible harm to animals, SA (Oct. 1999), 26, 30. On the ethics of pesticide testing in humans is discussed in Nature Medicine 5 (1999), 972. Public health lobbying is discussed in AJPH 89 (1999), 1425-9; BMJ 319 (1999), 839-40. On the history of public health, JAMA 282 (1999), 1589. New global health targets of WHO are discussed in BMJ 319 (1999), 700-3.

Some people exposed to water contaminated with aluminium sulphate had brain damage after the Camelford water incident, BMJ 319 (1999), 807-11. Aluminium dust may be associated with neurotoxicity, Lancet 354 (1999), 1575-6. State housing policy not to have lead-based paints has reduced lead poisoning in Massachusetts, AJPH 89 (1999), 1690-5. On the use of fluoride, Lancet 354 (1999), 74-5. The seasonality of birth of children with diabetes in Europe is discussed in BMJ 319 (1999), 887-8. Asthma is rising in poor urban areas, and it is not sure why, SA (Nov. 1999), 19-20.

A wide variation was found in a study, Simon, GE. Et al. "An international study of the relation between somatic symptoms and depression", NEJM 341 (1999), 1329-35; see also, AJPH 89 (1999), 1312-3. Attention deficit hyperactivity disorder in adults is discussed in MJA 171 (1999), 421-5. However one can also get weak with laughter, Lancet 354 (1999), 838. A UK study has not found a link between breast cancer and stressful life events, BMJ 319 (1999), 1015-6, 1027-30. Japanese guidelines for stressed workers are discussed in Lancet 354 (1999), 1273. On the consequences of unemployment, BMJ 319 (1999), 600-5. High blood pressure is linked to bone loss, Science News 156 (1999), 199; Lancet 354 (1999), 971-5. Bed rest can be potentially a harmful treatment, Lancet 354 (1999), 1229-33. Physical activity is associated with reduced risk of cholecystectomy in women, NEJM 341 (1999), 777-84; and type 2 diabetes, JAMA 282 (1999), 1433-9; Lancet 354 (1999), 1449. Exercise also reduces weight, JAMA 282 (1999), 1554-60. Efforts to increase activity are discussed in JAMA 282 (1999), 1515. The Princeton School Study suggest obesity is increasing, AJPH 89 (1999), 1708-14.

Reports from the Tokaimura radiation leak in Japan include Lancet 354 (1999), 1271; Science 286 (1999), 207-8; BMJ 319 (1999), 937, 1019-20; Nature 401 (1999), 513, 736; 402 (1999), 229-30; NS (9 Oct. 1999), 3-5; (30 Oct. 1999), 20-1. Also on radiation disease, Lancet 354 (1999), 845. Still births may be linked to Sellafield radiation exposure in workers, Lancet 354 (1999), 1400-1, 1407-14. After a nuclear plant closed in the UK there was decrease in radionuclides, EST 33 (1999), 2841+. Concrete dissolving bacteria may be useful for decontamination of radioactive sites, NS (9 Oct. 1999), 6. On storage of waste, NS (Oct. 1999), 21; Science 286 (1999), 415-6. Hiroshima survivors also appear to have high rates of heart disease or liver disease and strokes, NS (30 Oct. 1999), 17. On A-bombs, Nature 401 (1999), 117; NS (6 Nov. 1999), 19-9; Nature 401 (1999), 113-4.

On the dangers of cordless phones and health impact, Environment Health News 13 (July 1999), 9-10; The Ecologist 29 (Aug. 1999), 289-90. Some data on EMF fields was faked, SA (Oct. 1999), 32, 34. A review of how animals filter out noise into functional and non-useful noise, Nature 402 (1999), 241-2. Noise is also filling space so that astronomy is more difficult, Science News 156 (1999), 168-70.

On marihuana and medicine, NEJM 341 (1999), 854-5. A study found many illicit drug users are not idle, but employed, JAMA 282 (1999), 1320-1. On why people take drugs, Lancet 354 (1999), 1395. The US is trying biological control to control drug growth, NS (11 Sept. 1999), 3, 20-1. A study has found no impact for beta-carotene supplements and diabetes, JAMA 282 (1999), 1073-5.

The presence of a pit under the rails of some underground stations in London doubles the survival rate of persons hit by a train, BMJ 319 (1999), 957. On the safety of ear piercing, JAMA 282 (1999), 1332. Playing football may leave permanent head damage, NS (2 Oct. 1999), 24. Carbon monoxide poisoning is a winter problem, BMJ 319 (1999), 1082-3. Weapons are discussed in BMJ 319 (1999), 864-5; NEJM 341 (1999), 1583-9, 1609-11; and violence, AJPH 89 (1999), 1473+. On cycle helmets, BMJ 319 (1999), 1071-2. Breast implants are discussed in AJPH 89 (1999), 1763-4.

Cigarette warnings are discussed in AJPH 89 (1999), 1434; and on Japan Tobacco, Lancet 354 (1999), 843, 1456; Nature Medicine 5 (1999), 1091. The US government has sued tobacco companies over federal health care costs, Lancet 354 (1999), 1189; BMJ 319 (1999), 869. Few state tobacco tax dollars go to control of smoking, Nature Medicine 5 (1999), 1096. Regulation of carcinogens in cigarettees is discussed in Lancet 354 (1999), 1036. The WHO held its first session on an anti-tobacco accord, Lancet 354 (1999), 1622. Also on smoking, JAMA 282 (1999), 1284; BMJ 319 (1999), 1268. Chinese smoking figures for 1996 found 63% of men and 3% of women smoked, JAMA 282 (1999), 1247-53. A court decision in Florida that means the tobacco companies must pay over US$300 billion damages in a lump sum, but some executive sold their stock earlier, before the fall in stock prices, BMJ 319 (1999), 1153. A UK court has upheld a challenge to the 10 December ban on tobacco adverts that the EU imposed, BMJ 319 (1999), 1218. Discussion of high-nicotine tobacco is in Nature Biotechnology 17 (1999), 1041.

Moderate alcohol consumption can be linked to stroke prevention, NEJM 341 (1999), 1557-64, 1605-6. However alcohol also causes cirrhosis in excess, BMJ 319 (1999), 666-70. An arthritis drug has been suggested as a possible cure, NS (10 Oct. 1999), 10; Science News 156 (1999), 52. Also on alcohol, BMJ 319 (1999), 821-2. The coverage of alcohol issues in the print media in USA is reviewed in AJPH 89 (1999), 1555-60.


A press dossier on the Adoption of an Opinion on Doping in Sport by the European Group on Ethics in Science and New Technologies to the European Commission, has been released in Nov. 1999 (69pp.). Performance indicators of drug harm minimization are discussed in Bioethics Research Notes 11 (Dec. 1999), 37-9. Bionic nerves can help avoid muscle wasting after stroke, NS (11 Dec. 1999), 5. Lifestyle and bones are discussed in Lancet 354 (1999), 1923; Science 286 (1999), 1825.

Thalidomide is being used for Crohn's disease, Gastroenterology 117 (1999), 1271-7, 1485-98. Alternative medicine is discussed in Time (8 Nov. 1999), 50; JAMA 282 (1999), 1682-3; and in Ireland herbal remedies are on prescription, Lancet 354 (1999), 1799. The failure of a single dose of secretin to help children with autism is reported in NEJM 341 (1999), 1801-6, 1842-3; Lancet 354 (1999), 2140. A legal discussion of Halcion and negligence is Syracuse Law Review 48 (1999), 299-321. A series of papers on technology in medicine are in JAMA 282 (17 Nov. 1999), 1875+. The reuse of "single-use" medical devices is common, BMJ 319 (1999), 1320.

On how genes alter an individual's response to drugs is in GEN 19 (Dec. 1999), 6, 55; Time (8 Nov. 1999), 62. Accelerated drug review in the FDA is discussed in AJLM 25 (1999), 543-68; and generic equivalence studies, JAMA 282 (1999), 1995. A lawsuit by Canadian prisoners who claim they were given LSD in drug trials without conset is underway, Lancet 354 (1999), 2144. The death rate from ecstasy and heroin is discussed in Lancet 354 (1999), 2166-7. A series of papers are ina special issue, Agar, MH. & Kozel, NJ., eds., Ethnography and substance use: Talking numbers", Substance Abuse & Misuse 34 (No. 14, 1999), 1935-2172. A study of the quality of life of Thai persons who abuse substances is J. Rehabilitation (July 1999), 41-8.

A series of papers on alcoholism are in NS (27 Nov. 1999), 26-91. The dangers of early drunk driving are discussed in Lancet 354 (1999), 1788. Beer may have some protection against cancer, NS (4 Dec. 1999), 16. There is discussion of a possible ban on alcohol advertising in NS (27 Nov. 1999), 90-3. Addiction is discussed in The Economist (6 Nov. 1999), 99.

A Korean study shows that in Korea smoking is a major independent risk factor for cardiovascular disease, JAMA 282 (1999), 2149-55. The insurance costs of smoking are discussed in J. Law & Economics XLII (1999), 575-609. Passive smoking is more risky for women with a glutathione-S-transferase M1 deficiency, BMJ 319 (1999), 1522. Smoking cessation is discussed in AJPH 89 (1999), 1827-31; JAMA 282 (1999), 1722-3. The EU is planning tighter controls, BMJ 319 (1999), 1391. There is an on-line journal, <www.tobaccocontrol.com>. Tobacco smoking in children is a risk factor for a depressed mood, AJPH 89 (1999), 1837-40; however adverse experiences also tend to lead to smoking, JAMA 282 (1999), 1652-8.

Mandatory public health programs are discussed in Health & Human Rights 4 (1999), 193-203; also JAMA 282 (1999), 1812; NEJM 341 (1999), 1778. International health programs and regulations are discussed in Lancet 354 (1999), 2062. The major causes of death are discussed in Time (8 Nov. 1999), 64-5. On the risks of hearing loss after exploding airbags, NS (27 Nov. 1999), 7. Letters on correct use of car seats are in JAMA 282 (1999), 1721. The idea to regulate firearms as a consumer product is being discussed in the USA, Science 286 (1999), 1481-2. The Red Cross is trying to identify weapons too barbaric to use, NS (4 Dec. 1999), 14-5. There is little evidence that men who were prisoners of war in the far East have higher rates of death than general, Lancet 354 (1999), 2116-8.

On alternative medicine and ethics, CQHE 9 (2000), 83-97; JAMA 283 (2000), 56-7. In Germany some pain relief by spending severla minutes in a freezer is reported in Science 287 (2000), 579. On 28 January the FDA made another warning on the safety of drug sales over the Internet; and they will be regulated, BMJ 320 (2000), 75; FDA Consumer (Jan. 2000), 25-9. A call to regulate the generic drug market is BMJ 320 (2000), 7, 131-2. There is unlicensed drug use in medical wards for children in Europe, BMJ 320 (2000), 79-82. The question why some men die who take Viagra is discussed in JAMA 283 (2000), 590-3. The safety of FDA-approved drugs is discussed in JAMA 283 (2000), 2297-8. On the use of prescription drug information in pharmacy benefit programs, JAMA 283 (2000), 801-6.

In general on public health, JAMA 283 (2000), 37-8. A study of why mental health patients were less likely to undergo coronary revascularization procedures is JAMA 283 (2000), 506-11. Occupational health is discussed in AJPH 90 (2000), 186-7; Lancet 355 (2000), 124. Potted plants are not enough to heal sick building syndrome, NS (15 Jan. 2000), 5.

The WMA Declaration on Principles of Health Care for Sports Medicine is in BME 153 (1999), 10-1. The reason why alcohol damages the brain is discussed in Science 287 (2000), 947-8. In the US in 1997 and in 1998, 38% of deaths from traffic accidents were alcohol related, JAMA 283 (2000), 598-9. On alcohol dependence, AJPH 90 (2000), 53-6. The debate over use of cannabis should become more rational, BMJ 320 (2000), 108-10. Use of herbal remedies is discussed in NS (J22 an. 2000), 19. A book review of The Fix is NEJM 342 (2000), 140. The relationship between modifiable health risks and short term health changes is discussed in JAMA 283 (2000), 2235-9.

One cigarette reduces life expectancy by 11 minutes on average, BMJ 320 (2000), 53. A review of global tobacco litigation is BMJ 320 (2000), 111-3. India has given an exemption for tobacco tax in some states, Lancet 355 (2000), 381. On Canadian efforts, NS (29 Jan. 2000), 19. The decline in pregnancy-related smoking rates in the USA since 1986 may be due to less women starting smoking rather than special concerns on pregnancy, JAMA 283 (2000), 361-6. The Winston no additive campaign is examined in Public Health Reports 114 (1999), 522-5. It will be 50 years in August 2000 that tobacco and public health have been discussed in BMJ, BMJ 320 (2000), 74. WHO is increasing its attempts to stop tobacco use in developing countries, Lancet 355 (2000), 210. On the use of tobacco in the 1990s in the USA, JAMA 283 (2000), 2202-4. The idea to make safer cigarettes is discussed in NS (12 Feb. 2000), 5.

Recommendations on implants are in JAMA 283 (2000), 869. There are trends to use more breast conserving therapy for breast cancer in California, AJPH 90 (2000), 281-4. Fear of falling in the elderly has a detrimental affect on the quality of life, BMJ 320 (2000), 241-6.

The need for seat belt use and parallels with condoms are discussed in Lancet 355 (2000), 400-3. Youth violence is discussed in NEJM 342 (2000), 222-3. Violence in hospital is discussed in CMAJ 161 (1999), 1245-8. There is increased chance of violence by stalkers who have had previous sexual intimacy with the victims, Lancet 355 (2000), 199. Music therapy can work to help medical problems, JAMA 283 (2000), 468-9, 731-3.

A study of mental stress and risk of heart attack is JAMA 283 (2000), 1800-2. Statins that protect against heart attack also make some men impotent, NS (18 March 2000), 20. Folic acid may be useful, Lancet 355 (2000), 511, 517-22. Guidelines on preventing cardiovascular disease are discussed in BMJ 320 (2000), 659-61; 709-10. In general, NEJM 342 (2000), 746-7; Lancet 355 (2000), 668-9, 688-700, 1271-3. Gentle training is recommended for older hearts, Lancet 355 (2000), 629. On benefits of exercise, NEJM 342 (2000), 454-60, 502-5; Lancet 355 (2000), 515-6. Cycling may need a safer road environment, BMJ 320 (2000), 888. Heart disease is rising in central and eastern Europe, BMJ 320 (2000), 467.

A study has found estrogen does not help Alzheimer's disease, JAMA 283 (2000), 1007-15, 1055-6; Lancet 355 (2000), 727. An update on taxanes is Lancet 355 (2000), 1176-8. Italy is asking that drugs that have been on the market for 10 years be reassessed for their efficacy, Lancet 355 (2000), 732. Spain is altering their drug pricing policy and supermarkets have been trying to reduce prices of drugs, Lancet 355 (2000), 1081, 1166. Frequent paracetamol use has been linked to asthma in some people, Lancet 355 (2000), 1078. Letters on the Internet sale of Viagra are in NEJM 342 (2000), 740-1. Viagra also acts on the gut smooth muscle, Lancet 355 (2000), 631. A review of trials is Zivin, JA. "Understanding clinical trials", SA (April 2000), 69-75.

A survey of Australian oncologists' attitudes about non-traditional therapies used by cancer patients is MJA 172 (2000), 102-3, 110-3. [ed. One actually could say new medicine is not traditional!]. A controversial cancer therapy is discussed in Science 287 (2000), 2139-41.

Risk is discussed in BMJ 320 (2000), 723; Oxford J. Legal Studies 20 (2000), 109-30; EST 34 (2000), 1396-400. On public health in general and the US report Healthy People 2010, JAMA 283 (2000), 989-90; BMJ 320 (2000), 818-9. Letters on the HOPE study involving treatment of persons with diabetes with ramipril are discussed in Lancet 355 (2000), 1181-3. There are still questions over whether CS gas is dangerous, BMJ 320 (2000), 458-9.

A WHO study on the global extent of depression is reported in Science 288 (2000), 39-40; also MJA 172 (2000), 100-1. A discussion of methods to discover new drugs for mental disorders is NatBio 18 (2000), 307-9. On definitions of health and disease in Africa, SSM 50 (2000), 965-83, 1353-68. Work stress is surveyed in Singapore in SSM 50 (2000), 1415-22.

A book review of Asthma in the Workplace is NEJM 342 (2000), 1145. A book review on asbestos-related deaths is NS (15 April 2000), 38. The global burden of injuries is reported in AJPH 90 (2000), 523-6. On work-related deaths, AJPH 90 (2000), 533-45. Hazards of paint-spraying are reported in Lancet 355 (2000), 896. A comment on the incidence of neural problems in former prisoners of war is Lancet 355 (2000), 843.

There was a significant increase in prescriptions of psychotropic medicines to pre-school children in the 1990s in the USA, JAMA 283 (2000), 1025-30, 1059-60; BMJ 320 (2000), 602. The US government is attempting to improve the situation for children who have attention deficit hyperactivity disorder, Lancet 355 (2000), 1161; BMJ 320 (2000), 893; Newsweek (6 March 2000), 53. A WHO study on the health of children in 28 countries has been reported, BMJ 320 (2000), 402. Promotion of the health of children who are looked after is discussed in BMJ 320 (2000), 661-2.

A review on the ethics is Barnes, RE. "Reefer madness: Legal and moral issues surrounding the medical prescription of marijuana", Bioethics 14 (2000), 16-41. Illegal drugs are discussed in BMJ 320 (2000), 656, 886-7; Lancet 355 (2000), 585; JAMA 283 (2000), 1303-10, 1887; MJA 172 (2000), 284-6; AJPH 90 (2000), 335-7. A possible link between underage drunk driving and later violent crime is discussed in Lancet 355 (2000), 933. A review of alcohol problems is Frank, JW. Et al. "Historical and cultural roots of drinking problems among American Indians", AJPH 90 (2000), 344-51. A brain steriod may be the reason why women and men have different consequences and recovery from drinking alcohol, NS (March 2000), 19. Antihistamines may impair driving as much as alcohol, Lancet 355 (2000), 905. On abuse of prescription drugs, JAMA 283 (2000), 1126-7. Abuse of androgens is discussed in MJA 172 (2000), 220-4. Helium has been linked to several strokes, so people should be careful of helium balloons and not inhale it, BMJ 320 (2000), 732.

A paper finding no danger is Janowsky, EC et al. "Meta-analysis of the relation between silicone breast implants and the risk of connective-tissue diseases", NEJM 342 (2000), 781-90. A report from the scientific panel that considered the risks is NEJM 342 (2000), 812-5. On the ethics of clinical research in plastic surgery, BME 155 (2000), 2. Constructions of masculinity are discussed in SSM 50 (2000), 1385-401. The use of testosterone supplements is debated in Time (24 April 2000), 40-6.

Smoking and weight gain is discussed in FoodToday 19 (March 2000), 1-2. Cigarettes are also not good for physical appearance, NS (15 April 2000), 18. The Australian government has been criticized for giving tax concessions to the tobacco industry, BMJ 320 (2000), 667. A California jury has awarded a dying smoker US$22 million in damages, BMJ 320 (2000), 957. The US Supreme Court in a 4:3 decision said that the government FDA cannot regulate the tobacco industry, BMJ 320 (2000), 894. Tobacco is being debated in Canadian courts, CMAJ 162 (2000), 1265; see also BMJ 320 (2000), 535. Australia and New Zealand are considering class action suits, Lancet 355 (2000), 1251. Also on the war against tobacco, NS (4 March 2000), 40-3; BMJ 320 (2000), 391-2, 397, 399, 417-8, 454; AJPH 90 (2000), 337-9; Lancet 355 (2000), 636, 1168, 1188-9; JAMA 283 (2000), 1686-7, 1958-60. Smoking has been linked to invasive pneumococcal disease, JAMA 283 (2000), 1426-7, 1469-75; NEJM 342 (2000), 732-4; Lancet 355 (2000), 993. Tobacco smuggling is discussed in BMJ 320 (2000), 531. A study of how the tobacco industry tried to seed the medical literature with positive articles is Lancet 355 (2000), 1197, 1253-9. Increased CYP2D6 activity may be a predictor of smoking addiction, Pharmacogenetics 10 (2000), 5-10.

Violence and health is discussed in AJPH 90 (2000), 553-9; Lancet 355 (2000), 1116-7; JAMA 283 (2000), 1137-8, 1198-1203. Bullying in school is discussed in BMJ 320 (2000), 612-3. Those students who use illegal drugs in Scotland are also more likely to carry weapons, BMJ 320 (2000), 982-4. A ban on carrying firearms in two Colombian cities led to reduced homicide rate, JAMA 283 (2000), 1205-9, 1193-5. A study of deaths in Victoria, Australia from Australian football found 25 between 1968-1999, MJA 172 (2000), 217-9. A criticism of civilian bombing in Serbia during the Kosovo war is Lancet 355 (2000), 587; and on the Iraqi trade sanctions, AJPH 90 (2000).

A special issue of International Journal of Bioethics on health risks that includes three papers in French is in IJB 11 (March 2000), 9-42. The issue of compulsory medication through floridation of water is discussed in Environment & Health News 4 (Spring 2000), 1; and Ireland may relax its laws, BMJ 320 (2000), 1560. The politics of herbal drugs in Korea are discussed in SSM 51 (2000), 505-9. A case where a prescription drug has been packaged and sold as a herbal remedy in China is reported in JAMA 283 (2000), 2393. Cults in Japan have been marketing alternative health remedies, Lancet 355 (2000), 1797. The dangers to children of joining drug trials are discussed in US News & World Report (17 April 2000), 62+. There is still lack of clear evidence that vaccinations caused Gulf War syndrome, BMJ 320 (2000), 1351-2. Japan is to monitor the side effects of all new drugs, BMJ 320 (2000), 1560.

Wider use of the drug tamoxifen has accounted for a fall in breast cancer death rates in the UK by a third, and in the USA by a quarter, since 1990, BMJ 320 (2000), 1428. Better screening may have helped also. There is caution concerning the potential new cancer drug TRAIL, Science 288 (2000), 786-7. Taxol has been approved in the UK for ovarian cancer, BMJ 320 (2000), 1293. A call for study of the psychosocial outcomes in cancer survivors is Lancet 355 (2000), 1310-4. Assessing risk of breast cancer is discussed in NEJM 342 (2000), 2002-3. Effects of population screening for Helicobacter pylori are discussed in Lancet 355 (2000), 1665-9.

A report on silicone breast implants is Health Council (Netherlands) Network 15 (April 2000), 3. A call for a more responsible media image of bodies is called for in BMJ 320 (2000), 1495. Ethical issues of cosmetic surgery in Down syndrome are raised in JME 26 (2000), 101-2. A rival for Viagra has been supported by a FDA committee, BMJ 320 (2000), 1094. Physical activity lowers risk of stroke in both men and women, JAMA 283 (2000), 2961-7.

The use of drugs in children to alter bad behaviour is discussed in NS (20 May 2000), 44-5. On treatment of chronic depression, NEJM 342 (2000), 1518-20. The Netherlands is tightening alcohol advertising rules to try to stop childhood drinking, BMJ 320 (2000), 1094. People with a difficult childhood may drink more, NS (3 June 2000), 10. Bacterial poisoning through heroin injections have been fatal for some, NS (20 May 2000), 4; BMJ 320 (2000), 1559. In Spain drug overdose deaths will led to brain removal within 2 hours of for autopsy, Lancet 355 (2000), 1889. Cocaine use in Spain is increasing, Lancet 355 (2000), 2230. On stalking in the UK, BMJ 320 (2000), 1486-7. On drug use, Lancet 355 (2000), 1822-3; and gambling, BMJ 320 (2000), 1556.

Incidence of asthma is increasing worldwide, SA (June 2000), 30; AJPH 90 (2000), 929-35. Indoor endotoxin exposure early in life may protect against allergen sensitization, supporting the hygiene hypothesis, Gereda, JE et al. "Relation between house-dust endotoxin exposure, type 1 T-cell development, and allergen sensitization in infants at high risk of asthma", Lancet 355 (2000), 1680-3; 1795. In Japan some houses seem to cause allergies and disease, Lancet 355 (2000), 1798.

Increased stress may be behind falling life expectancy in Eastern Europe, Science 288 (2000), 1732-3. Adverse work environment is associated with adverse health, BMJ 320 (2000), 1432-6. A review of temperature stress is Int. Arch. Occup. Environ. Health 73 (2000), 215-20. Panic disorder is discussed in JAMA 283 (2000), 2573-4.

Italy is attempting to reduce passive smoking, Lancet 355 (2000), 1896. Dutch workers are entitled to some-free work conditions, BMJ 320 (2000), 1227. Jordan is attempting to lower its high rate of smoking, Lancet 355 (2000), 1800. Four tobacco firms are fighting the UK ban on advertisements, BMJ 320 (2000), 1427; also on adverts, JAMA 283 (2000), 2106-7. A Canadian former tobacco executive has sued Imperial Tobacco for misleading the public about the health affects of tobacco, Lancet 355 (2000), 1341. A Spanish case is reported in BMJ 320 (2000), 1028. Smoking and the brain is discussed in BMJ 320 (2000), 1087, 1097-1102. On smoking cessation, AJPH 90 (2000), 751-6, 757-61; JAMA 283 (2000), 2174, 3244-54. Discussion of so-called safer cigarettes are questioned in JAMA 283 (2000), 2507-8. Addiction is general is discussed in JAMA 283 (2000), 2644-5.

A call to reduce speed limits to 20 mph in urban areas is made in BMJ 320 (2000), 1160. Most children injured in drunk driving accidents are unrestrained in seatbelts or car seats, JAMA 283 (2000), 2249-52; also pp. 2245-8, 2291-2. Violence is discussed in BMJ 320 (2000), 1088-9; and in child's G-rated animated films violence is often seen, JAMA 283 (2000), 2716-20. In general on health impact assessment, BMJ 320 (2000), 1395-8. Cultural aspects of violence against women in Japan are discussed in Lancet 355 (2000), 1810. On men's health, NEJM 342 (2000), 1926-7. Models of public health practice from Don Quixote, Machiavelli and Robin Hood are discussed in AJPH 90 (2000), 702-6.

Guidance for the development and assessment of new nonprescription drugs in Japan is reported in Clin. Evaluation 27 (2000), Suppl. XIV 29-39. The selling of drugs deemed unsafe in the USA in Asia is discussed in Far Eastern Economic Review (3 August 2000), 56-7. The US NICE has approved taxanes for breast cancer, BMJ 320 (2000), 1688. Reducing drug-related deaths are discussed in Lancet 356 (2000), 7. Alternative medicines are discussed in Science 289 (2000), 245. Avoiding harm in migraine treatment and mistreatment is discussed in MJA 172 (2000), 412-3. Consumer health information is discussed in BMJ 320 (2000), 1713-6; 321 (2000), 247. On placebos, Newsweek (21 Aug. 2000), 56.

Public health and humanitarian interventions are discussed in BMJ 321 (2000), 101-5; Lancet 356 (2000), 503. Social issues and public health are discussed in AJPH 90 (2000), 1189-91. On attitudes to health and hygiene, Health & Place 6 (2000), 25-32. Religious commitment is linked to longer life, Science News 157 (2000), 359. The health costs of war are reviewed in BMJ 321 (2000), 169-72; JAMA 284 (2000), 569-77. Mortality among UK Gulf War veterans is not different from the general public, Lancet 356 (2000), 17-21. Differences in antidepressant use by race are surveyed in Am.J. Psychiatry 157 (2000), 1089-94.

Saline breast implants are still being sold on the US market, with warnings, FDA Consumer (July 2000), 9-11. Those at risk of breast cancer can have positive outcomes from prophylactic mastectomy because of less anxiety, JAMA 284 (2000), 319-24. On the safe way to use sunscreens, FDA Consumer (July 2000), 14-21; Env. Health Perspectives 108 (2000), A15. Cycling risks are discussed in BMJ 321 (2000), 386-7; NS (22 July 2000), 16-7. Stopping children being hit by parents is important, Lancet 356 (2000), 1. Reducing violence is called for in Nature 406 (2000), 567; Science 289 (2000), 545, 570-96; JAMA 284 (2000), 551-3. On gun control, JAMA 284 (2000), 585-91, 616-8. Promoting health is discussed in AJPH 90 (2000), 1320-1.

Smokers perceptions of risks are discussed in AJPH 90 (2000), 1318-9. Developments in legal medicine and smoking are discussed in AJLM 26 (2000), 187-204. Counseling mothers on harms to their children can be effective to reduce children's exposure, BMJ 321 (2000), 310-1, 337-42; and children now receive on average half the tobacco smoke they used to, BMJ 321 (2000), 343-5. On smoking restrictions, BMJ 321 (2000), 309-10, 333-7, 389; J. Health Economics 19 (2000), 421-37; and the economics at a global level, BMJ 321 (2000), 358. A report from the US$145 billion damages award to Florida smokers from the tobacco industry is BMJ 321 (2000), 193, 322; Nature 406 (2000), 226. On the strategies used by tobacco companies against WHO, BMJ 321 (2000), 319; and Operation Berkshire and other campaigns, BMJ 321 (2000), 313-5, 371-4; Lancet 356 (2000), 336-7; Nature 406 (2000), 547. On Irish tobacco lawsuits, Lancet 356 (2000), 492; and changing the trends towards smoking in China, Lancet 356 (2000), 432-3. On health dangers, BMJ 321 (2000), 311-3, 323-9; MJA 172 (2000), 550+; Lancet 356 (2000), 139. Candy cigarettes tempt young people to smoke, BMJ 321 (2000), 362-5. On advertising tobacco, BMJ 320 (2000), 1691; 321 (2000), 366-71. Nicotine calms women but provokes men, Lancet 356 (2000), 226. Phenotypic and genetic factors in motives for smoking are discussed in Behavior Genetics 29 (1999), 291+.

A Brazilian study on harm avoidance and dopamine D2 receptor and alcoholism is AJMG 96 (2000), 302-6. Alcohol preference may be regulated by the neuropeptide Y system, AJMG 96 (2000), 117-21. A positive link between moderate drinking and cognitive performance in later life is seen in the Honolulu-Asia aging study, AJPH 90 (2000), 1254-9. On mice models of drug exposure, Science 289 (2000), 463-5. A US federal judge has approved the distribution of medical marijuana from a club for medical purposes, BMJ 321 (2000), 261. Australia is funding drug control but not tobacco control, MJA 172 (2000), 612-3.

Whether zinc helps fight colds or not is debated in Science News 158 (2000), 155. A survey in India found time expired medicines contributed to 26 deaths in A Delhi hospital, BMJ 321 (2000), 590. On unapproved use of drugs, NEJM 343 (2000), 1125. A discussion of the pill ecstasy is Time (23 Nov. 2000), 42-8. Heroin prescription for addicts in Switzerland improves their QOL, Lancet 356 (2000), 1177. On opioid dependence, NEJM 343 (2000), 1332-3; NS (21 Oct. 2000), 23. Cannabis use has fallen among the Dutch youth, BMJ 321 (2000), 655. Medical use is discussed in BMJ 321 (2000), 979; Nature 407 (2000), 6, 18-9. Genetics of substance use disorders is discussed in AJMG 96 (2000), 585-699. A review of substance abuse in Croatia is Croatian Medical J. 41 (2000), 270-86.

On melatonins and sleep, NEJM 343 (2000), 114-6. Progress to improve memory is discussed in Time (30 Oct. 2000), 38-45. Ginkgo is not effective for memory loss in elderly patients, Lancet 356 (2000), 1333. A claim that drug trial design has led to stopping a clinical trial in Japan is Lancet 356 (2000), 1192-3. Statins are said to be under used, BMJ 321 (2000), 971-2. The UK drugs industry has set up a trials register, BMJ 321 (2000), 850. On adverse reactions, Lancet 356 (2000), 1255-9.

Parent groups have sued psychiatrists for promoting Ritalin that is meant to treat hyperactive children, BMJ 321 (2000), 723. A Duke University study attacks the overuse of stimulants in children, Science 289 (2000), 721; JAMA 284 (2000), 2043-4; MJA 173 (2000), 172-3; BMJ 321 (2000), 975-6. A book review of Manufacturing Victims: What the Psychology Industry is Doing to People is BMJ 321 (2000), 902. Phthalates are components of plastics that may harm developing boys, Science News 158 (2000), 152-4. Speech therapy of children is discussed in BMJ 321 (2000), 908-9. Exposure of children to other children or siblings reduces risk of asthma and wheezing, NEJM 343 (2000), 538-43, 574-5. Asthma, steriods and growth is discussed in NEJM 343 (2000), 113-4; Time (6 Nov. 2000), 68. Pediatric study of side effects of medicines has become mandatory in the USA, NatMed. 6 (2000), 1069. Antipsychotic drug use is a risk factor for venous thromoboembolism, Lancet 356 (2000), 1206, 1219-23. The 2000 Nobel Prize has gone to three researchers on the brain, NS (14 Oct. 2000), 7. There is an association between oestradiol concentration and cognitive decline prediction in women, Lancet 356 (2000), 694. There are some ideas that a slowdown in brain cell growth may be linked to depression, Science 289 (2000), 258-9. On depression medicines, MJA 173 (2000), 454-5. Maggot therapy is making a comeback, Lancet 356 (2000), 1174. Tamoxifen is useful to prevent breast cancer but it has some risk of endometrial cancer, Lancet 356 (2000), 868, 881-7.

The possibility of smoking genes is discussed in Science 289 (2000), 2271; and the first cigarette can hook some people, NS (26 Aug. 2000), 11. Women are more sensitive to nicotine, NS (7 Oct. 2000), 20. The biology of harm from smoking is discussed in Lancet 356 (2000), 1499. Not only tar but a fungal mould in tobacco may harm health, NS (30 Sept. 2000), 18. Vitamin C may restore early coronary impairments in smoking, Lancet 356 (2000), 1007. Cessation of smoking reduces the risk of age-related cataracts in men, JAMA 284 (2000), 713-6. In general on harm, JAMA 284 (2000), 735-40. India is increasing its antismoking measures, Lancet 356 (2000), 1089. There is a high rate of smoking among indigenous Australians caused by smoking, MJA 173 (2000), 288-9, 301-4. Ireland has taken a strong position, Lancet 356 (2000), 1254. Worldwide control is discussed in JAMA 284 (2000), 750-3; Lancet 356 (2000), 1420. On US tobacco politics, BMJ 321 (2000), 967; JAMA 284 (2000), 697, 699-705, 706-12. Police in Hong Kong have a high exposure to smoke, JAMA 284 (2000), 756-63. Smoking may increase the risk of anxiety disorders in late adolescence and early adulthood, JAMA 284 (2000), 2348-51. Parents should make smoke-free homes, JAMA 284 (2000), 717-22. Reducing cigarette smuggling is still a serious problem, BMJ 321 (2000), 947-50. The question of whether scientific journals should publish research funded by the tobacco industry is discussed in BMJ 321 (2000), 1074-5.

Basic handwashing is important to reducing infectious disease, Lancet 356 (2000), 1290-1, 1307-12; NS (14 Oct. 2000), 21. Use of emergency defibrillation can save lives, NEJM 343 (2000), 1206-9, 1210-6, 1259-60; JAMA 284 (2000), 1435-41. A study of the increase in life expectancy in Sweden is Science 289 (2000), 2366-8. Stress in Eastern Europe is arguably related to decline in life expectancy there, Science 289 (2000), 52-3. On bone loss, JAMA 284 (2000), 1018-9; Science 289 (2000), 1497-508. Lead in calcium supplements is discussed in JAMA 284 (2000), 1432-3. Sunlight and plastic bottles may be good ways to sterilize water, NS (26 Aug. 2000), 14.

The development of genomic approaches to studying the differences in people's responses to toxins and drugs is reviewed in GEN 20 (1 Sept. 2000), 1, 22, 25. On insulin-like growth factor 1 and cancer, BMJ 321 (2000), 847-8. A call for more environmental health studies has been made in Canada, Lancet 356 (2000), 921 (see also Environment section). A series of papers on Environment and health including topics like the impact of war, CMAJ 163 (2000), 1157-61; Cancer, pp.1009-15; Population, consumption, pp. 551-6, 533-4; Ozone depletion and ultraviolet radiation, pp. 851-5; Global climate change, pp. 729-34. There can be overestimation of risk from pollutants, EST 34 (2000), 4259-65. Travel is a risk factor for venous thrombosis, Lancet 356 (2000), 1492. Silica-exposed workers have increased risk of renal disease, Lancet 356 (2000), 913. On coal dust and causation of disease, Modern Law Review (2000), 763-73. On fluoridization and teeth, BMJ 321 (2000), 844-5, 855-9. On public health along the US-Mexico border, Lancet 356 (2000), 1020-2; and in developing countries, Lancet 356 (2000), 787, 841-6. Homeopathy is discussed in BMJ 321 (2000), 471-6. Alternative medicines are discussed in Lancet 356 (2000), 1422. Probiotics may improve health, JAMA 284 (2000), 1365-6. On traditional medical care in North America, JAMA 284 (2000), 1370. Placebos are discussed in Newsweek (21 Aug. 2000), 56. The use of the SF-36 questionnaire in New Zealand is reported in SSM 51 (2000), 1655-64. On health camps in New Zealand, SSM 51 (2000), 1047-59.

The harms of the germ line damage after Chernobyl are discussed in Nature 407 (2000), 583. The hazards of working with radiation are reviewed in FDA Consumer (Sept. 2000), 11-12. The effects of the nuclear bombs continue in survivors, Lancet 356 (2000), 1009. On nuclear transmutation, EST 34 (2000), 420-1A. Sunken Russian nuclear submarines are ecological time bombs, SA (Nov. 2000), 18; Science News 158 (2000), 159. Proximity of the radiation induced mutation to certain gene elements is important for cancer, Science 290 (2000), 62-1, 138-41. There are questions whether radiation monitors really work, NS (Sept. 2000), 15. On nuclear power, Nature 406 (2000), 679. A metallic oxide erbium zirconate has been found that may be useful to store radioactive waste for 1000 years, NS (12 August. 2000), 6; see also Science 289 (2000), 2051-2. Concerns over mobile telephones are discussed in SA (Sept. 2000), 20-1; NS (7 Oct. 2000), 21. Hands-free phones may be safer, BMJ 321 (2000), 468. Mobile telephones are banned on aircraft but some also think computers should be, NS (19 Aug. 2000), 18-9. Emission of an allergen triphenyl phosphate may be a real harm factor from VDUs, EST 34 (2000), 3885-9.

On exercise and heart disease, NEJM 343 (2000), 572-4, 1409-11; Lancet 356 (2000), 1208-10. A call to use bicycle helmets is made in BMJ 321 (2000), 1035-6. There has been a 700% increase in the scooter injury rate in the USA since May 2000, BMJ 321 (2000), 655. The cause of Gulf War syndrome is a mystery, Nature 407 (2000), 121. Violence as a health risk is discussed in Lancet 356 (2000), 1367. On pathological gambling, NEJM 343 (2000), 1050-1. Injury is often overlooked, JAMA 284 (2000), 950-1. Visual standards for driving are discussed in BMJ 321 (2000), 972-3.

India plans to use both traditional and mainstream medicine together, Lancet 356 (2000), 1665; Lancet Perspectives 356 (2000), s3-4; and on a study in China, SSM 52 (2001), 149-53. This debate is also seen in the UK and other countries, BMJ 321 (2000), 1133-5, 1365, 1523-6. Maggot therapy is discussed in www.homestead.com/biotherapy. There has been controversy over the introduction of apotheke.com, which will link all German pharmacies and sell drugs over the Internet, Lancet 356 (2000), 1912. Research that health behaviour is not conditional to income adequacy in Canada is SSM 51 (2000), 1741-54. Drug labeling is discussed in JAMA 284 (2000), 3047-8. In general on public health, Lancet 356 (2000), 1769-70, 1923-5.

Release of drugs and growth factors from extracellular matrices should be improved, Nature 408 (2000), 998-1000. On drugs in the genomics age, JAMA 284 (2000), 2786-7; Lancet 356 (2000), 1667-71. In general on the future of drug research, Time (22 Jan. 2001), 30-48.

The ethics of drug trials in less developed countries are discussed in Lancet Perspectives 356 (2000),; s37. The ethics of concealing medication in patients food is discussed in Lancet 357 (2001), 62-4. Economic and heath benefits are expected from increased use of beta-blockers following myocardial infarction, JAMA 284 (2000), 2748-54. Marital stress worsens prognosis in women with heart disease, JAMA 284 (2000), 3008-14. Marriage has a positive role in cancer survival, SSM< 52 (2001), 357-68. Stress is dangerous to health, Lancet 357 (2001), 126. Long-live is discussed in BMJ 321 (2000), 1580-2. The ethics of treating aplastic anemia are discussed in Lancet 356 (2000), 1536-7.

In the USA Vector Group Ltd. is planning to introduce a cigarette made from a GM tobacco that is virtually nicotine free and may be a tool to quit smoking<, Plant Biotech Week (13 Jan. 2001), 8. On Eclipse cigarettes, JAMA< 284 (2000), 2995-6. FDA regulation of tobacco products is discussed in NEJM 343 (2000), 1802-9. Studies in China find fewer rural people smoke than urban people, AJPH 90 (2000), 1785-7. A Florida jury has awarded a husband damages of US$200,000 from his wife’s death from smoking, BMJ 321 (2000), 977. US smoking statistics for smoke-free work environment are in JAMA 284 (2000), 2865-6. California’s antismoking campaign has already reduced heart disease, NEJM 343 (2000), 1772-7.; Persons with mental illness are twice as likely to smoke, JAMA 284 (2000), 2606-10. The genotype CYP2A6 and smoking habit is discussed in Annals Human Genetics 64 (2000), 383-90. Israel’s military has been condemned for issuing free cigarettes as it breaks a 1983 law, BMJ< 321 (2000), 1242. A class action in Israel has been settled out of court, BMJ 321 (2000), 1306. A call for antismoking education in Kuwait is made in Bulletin WHO 78 (2000), 1306-15. The appearance of cigarette brands in films contributes to global cigarette marketing, Lancet 357 (2001), 29-32. On the Australian Tobacco Institute, BMJ 321 (2000), 620. The question of publishing articles funded by tobacco money is raised in BMJ 321 (2000), 1074-6. Nicotine metabolism may create yet another carcinogen, Science News 158 (2000), 278. Colorectal cancer is also a risk of smoking, Lancet 356 (2000), 2072.; On passive smoking, BMJ< 321 (2000), 1221-3. Benefits to the brain from alcohol are discussed in NS (9 Dec. 2000), 10. The origin of cocaine is discussed in Nature 408 (2000), 311-2.

A discussion of handling hazardous chemicals is in Occupational Health & Safety (Dec 2000), 58-60. Workplace bullying is discussed in Lancet 356 (2000), 2118. Back-belt use may not lower risk of back damage, JAMA 284 (2000), 2727-32, 2780. On inflight medical emergencies, BMJ 321 (2000), 1336-41; Time (20 Nov. 2000), 94. On osteoporosis, Scrip Magazine (Dec. 2000), 19-21. Hip protectors help avoid injury, NEJM 343 (2000), 1562-3.

Persons who were prescribed statins have a decreased risk of Alzheimer’s disease, Lancet 356 (2000), 1627-31; BMJ 321 (2000), 971-2. Tamoxifen has been found not to increase risk of cardiovascular disease, Lancet 357 (2001), 45. The dangers of aspirin and links to asthma are discussed in BMJ 321 (2000), 1170-1, 1178. On the risk of asthma and siblings, NEJM 343 (2000), 1967-8. The component of some appetite suppressants, phenylpropanolamine is a risk factor for stroke, NEJM 343 (2000), 1826-32, 1886-7. On silicone breast implants, AWHONN 4 (Oct. 2000), 29-32.

A call for more bicycle helmet use is made in BMJ< 321 (2000), 1035-6. Use of injury data to prevent violence is discussed in BMJ 321 (2000), 1481-2. The question of the difficult line between mental disease and criminal is discussed in Lancet Perspectives 356 (2000), s48. In Norway there is a seasonal pattern of violence, Am. J. Psychiatry 157 (2000), 1674-8.; The Sabbath affects Jewsih mortality in Israel, SSM 52 (2001), 83-97.

Low dose aspirin helps prevent heart attacks, Lancet 357 (2001), 89-95. The UK NICE has approved widespread use of 3 drugs for Alzheimer's disease, BMJ 322 (2001), 190. Research into complementary and mainstream medicine is discussed in BMJ 322 (2001), 154-8, 161-4; and on regulation, BMJ 322 (2001), 158-60. The FDA has been acting against some web-based pharmacies, NatMed. 7 (2001), 6. Ginkgo biloba does not appear to be useful for treating tinnitus, BMJ 322 (2001), 73-5. Acupuncture is reviewed in Nature 409 (2001), 560-1. The system by which the liver copes with toxins is discussed in Science 291 (2001), 35-7. In general on public health, BMJ 322 (2001), 184-5; NatMed. 7 (2001), 15.

Socioeconomic status is associated with type 2 diabetes in women, AJPH 91 (2001), 76-83. A letter on near-work and myopia in young children is discussed in Lancet 357 (2001), 390. The drug methylphenidate used in treatment of attention deficit hyperactivity disorder works by increasing dopamine levels, BMJ 322 (2001), 259. A book on the health effects of alcohol has been criticized for not acknowledging that it was financed by the alcohol industry, BMJ 322 (2001), 319. A US study suggests less people progressed to hard drugs than predicted earlier from marijuana use, AJPH 91 (2001), 225-32.

A book review of Adonis Complex: The Secret of Male Body Obsession is NEJM 344 (2001), 146-7. A book review on Masculinity and Femininity is SSM 52 (2001), 653. A psychological benefit can be seen in women who use prophylactic mastectomy, BMJ 322 (2001), 76-9. Letters on breast conserving surgery are in Lancet 357 (2001), 305. A call to reduce speeds in urban areas to 20mph is in BMJ 322 (2001), 50-1. It is better to stay sober on flights to avoid blood clots, NS (13 Jan. 2001), 7; BMJ 322 (2001), 188. The question of what is a disease is discussed with the idea of post-traumatic stress disorder, BMJ 322 (2001), 95-8. On mental stress at work, SSM 52 (2001), 499-507; AJPH 91 (2001), 270-6. Use of 1,4-butanediol is associated with adverse health effects, NEJM 344 (2001), 87-94; as is coal mining, JAMA 285 (2001), 339-40.

Injuries kill over 20,000 children a year in developed countries alone, BMJ 322 (2001), 317. A Rhode Island study has found that car seat laws save lives, AJPH 91 (2001), 311-3. On the apparent lack of health effects of cellular telephones, NEJM 344 (2001), 79-86, 133-4. Radiation overdose is common in CT scans of children, Lancet 357 (2001), 285. On tobacco companies methods to lure smokers, BMJ 322 (2001), 237-7.

A call for an International Agreement on tobacco control is made in AJPH 91 (2001), 191-3. The WHO draft international treaty has no ban on sponsorship or advertising, Lancet 357 (2001), 370; and on model societies to predict the rise of tobacco use, AJPH 91 (2001), 206-12. There has been renewed debate on tobacco control in Europe, NatMed. 7 (2001), 5, 13-4; BMJ 322 (2001), 7. There is often inadvertent tobacco advertising in Physician's offices, JAMA 285 (2001), 43-44. Genomic studies on addiction are discussed in Nature 409 (2001), 834-7. Despite better knowledge, smoking in pregnancy has not decreased in Finland in the past decade, AJPH 91 (2001), 284-6. About 20% of 8th grade students in Buenos Aires are smoking, AJPH 91 (2001), 219-24. Behavioral counseling for fat intake, smoking and activity can be useful, AJPH 91 (2001), 265-9. Passive smoking increases risk of periodontal disease, AJPH 91 (2001), 253-7.

A new book in English and Japanese is Lagakos, SW. & Takeuchi, M., eds. Bridging Strategies. Extrapolating Data to New Regions for Drug Development, which is the proceedings of the First Kitasato University-Harvard School of Public Health Symposium, Clinical Evaluation 28 (Suppl. XV. 2001, 219pp.). A review of the therapeutic opportunities in polyglutamine disease is NatMed 1 (2001), 418-23.

On the epidemic of allergies in modern times, Pathways 2 (April 2001), 42-5.

A book review on the smoking industry, Kessler, D. A Question of Intent (Public Affairs, 2001, 491pp.) is in NatMed 1 (2001), 401. A cyclin-dependent kinase (Cdk5) may dampen the effects of cocaine, Science 292 (2001), 236-7.

The affect of corticosteriods on growth of children using them for asthma is discussed in NEJM 344 (2001), 607+.

In general on public health, Lancet 357 (2001), 976-7.

Smoking prevalence rates in Bulgaria have increased from 1986 to 1996, AJPH 91 (2001),455-7.

The risks of using laser surgery to correct myopia are discussed in Time (7 May 2001), 51. On the placebo effect, Newsweek (18 June 2001), 49.

In mi-May the new kinase inhibitor Gleevec was approved for treatment of chronic myeloid leukemia by the FDA, NatBio 19 (2001), 599-600; JAMA 286 (2001), 35. On risks and uses of statins, Biotechnology News (29 June 2001), 6-7. On prostrate cancer drug treatment, JAMA 286 (2001), 34, 406-8

A review of Europefs fast track plan for drug approval, expected to half the time needed, is BioCentury (23 July 2001), A7-8; Nature 412 (2001), 364; BMJ 322 (2001), 1187. A series of papers in Japanese on clinical evaluation of OTC drugs and traditional drugs is in Clinical Evaluation 29, Suppl. XVI (2001), 172pp. Drug reforms in Korea caused controversy, Lancet 357 (2001), 697. Argentina is attempting to crack down on the black market in pharmaceuticals, Lancet 358 (2001), 47. A study in Nigeria found half the drugs sampled had the wrong dose, JAMA 286 (2001), 159. Indian trade in fake drugs is discussed in Lancet 357 (2001), 1776. Many fake drugs are entering the USA, BMJ 322 (2001), 1443; Lancet 357 (2001), 1904. Physician-patient communication about over-the-counter medicine is also important, SSM 53 (2001), 357-69.

A study of non-biomedical health care practices in Mexico is Sociology of Health and Illness 23 (2001), 3-23; also Economic Botany 54 (2000), 427-38. A review of complimentary medicines is NS (26 May 2001), 28-52. On alternative medicines in the USA, JAMA 286 (2001), 156-8. Herbal drug licensing in Ireland is being introduced, Lancet 357 (2001), 206. Trials of acupuncture are discussed in JAMA 285 (2001), 1015-16. A review of the neuromodulatory effects of Ginkgo biloba is PNAS 98 (2001), 6577-80. On the use of targeted drugs, Lancet 357 (2001), 1593. On estrogen therapy, NEJM 344 (2001), 1242-4, 1784-5. On boron deficiencies, Science News 159 (2001), 228.

Carcinogen-specific induction of genetic instability is reported in PNAS 98 (2001), 5770-5. The mechanism of resistance to a new anti-leukemia drug, Gleevic, is reviewed in Nature 412 (2001), 281-2; SA (Sept. 2001), 13-4; FDA Consumer (July 2001), 6; BioCentury (25 June 2001), A10, 12. Also on new cancer drugs, Time (21 May 2001), 50-1. On taxol, BMJ 323 (2001), 115. Discussion of the search for new risk factors for cancer is in AJPH 91 (2001), 357-364; Nature 411 (2001), 390-5. The role of lifestyles and the risk of breast cancer are discussed in BMJ 322 (2001), 586-7. The idea to tack a weekly pill, oltipraz, to mop up cancer-forming chemicals is being tested, NS (7 April 2001), 4. In the tropics it is an advantage to have darker skin, NS (28 April 2001). Agent Orange may be linked to leulemia in children of Vietnam war veterans, Nature 410 (2001), 1016.

Exposure to some toxins may help the body get in better shape, NS (17 March 2001), 42-5. A new study has found that moderate chronic use of common analgesics does not result in kidney damage, BMJ 323 (2001), 184. WHO is attempting to help hearing disabilities in the developing world, Lancet 358 (2001), 219. The FDA reporting of adverse reactions to phenylpropanolamine is outlined in FDA Consumer (Jan 2001), 9. On pharmacogenomics, Lancet 357 (2001), 1020; NatMed 7 (2001), 281-3; Nature 410 (2001), 855; BMJ 322 (2001), 1068.

A review on treatment of asthma is JAMA 286 (2001), 395-8; BMJ 323 (2001), 253-6. A review of the use of fungal hydrophobins in medicine and technology is Appl. Microbiol. Biotechnology 56 (2001), 1-8. A book review on the use of thalidomide is Nature 410 (2001), 411-2; Lancet 357 (2001), 1893. Clioquinol for treatment of Alzheimerfs disease in Japan is discussed in Science 292 (2001), 2251-2. Use of antihypertensive drugs in Japan is discussed in Lancet 357 (2001), 720-1. On statin therapy, JAMA 285 (2001), 1850-5, 1888-9; 286 (2001), 532-4, 669-70; Science 292 (2001), 1160+; Amer. J. Med. 110 (2001), 716-23, 738-9. Statins and the prevention of dementia is reviewed in CMAJ 165 (2001), 908-10. Living in a disadvantaged neighbourhood is associated with increased incidence of coronary disease, beyond affects of income, education and occupation, NEJM 345 (2001), 99-106.Global cardiovascular disease prevention is discussed in Lancet 358 (2001), 661-3. Even light physical activity can decrease the incidence of coronary heart disease in women, JAMA 285 (2001), 1429-31, 1447-54, 2973-4. On links to mortality, AJPH 91 (2001), 578-83. On marital stress and heart disease, JAMA 285 (2001), 1289-90. On the CONSORT statement for clinical trials, JAMA 285 (2001), 1987-91, 1992-5, 1996-9, 2000-5, 2006+, 2076-8. Use of placebo is discussed in Science 292 (2001), 2013-4; Lancet 357 (2001), 1721.

The influence of the Berlin Wall on German health is discussed in AJPH 91 (2001), 369-74. Changes in life expectancy in Russia in the mid-1990s is reviewed in Lancet 357 (2001), 917-21, 2058. A prediction that increases in life expectancy will be smaller in the future is BMJ 322 (2001), 512. On public health in general, Lancet 358 (2001), 516; The Ecologist 31 (May 2001), 40-5; JAMA 285 (2001), 3148-9. Noise pollution in Japan is discussed in Japan Quarterly (Jan 2001), 78-84.

A study of students undergoing stress during exams found that their DNA repair capacity was higher in times of stress, J. Behavioral Medicine 23 (2000), 531+. A study of depression amongst first year university students in Japan is in Psychiatry and Clinical Neurosciences 54 (2000), 583-8. A discussion of pathological gambling is JAMA 286 (2001), 141-4. Letters on the risks of deep vein thrombosis and air travel are in Lancet 357 (2001), 553-5, 1461-2; BMJ 322 (2001), 1183-4; MJA 174 (2001), 264-5.

Enforcement of housing policies can break the cycle of environmental lead exposure to children, AJPH 91 (2001), 621-4. Discussion of a missed opportunity to study the health effects of dams is Lancet 357 (2001), 570-1. Increasing the ambulance time to 5 minutes would double the survival rate for cardiac arrests, BMJ 322 (2001), 1385-8.

The effects of neighbourhood on the cognitive level of children are much smaller than those of family in the British National Child Development Study, SSM 53 (2001), 423-40, 579-91. New Zealand revised its guidelines for prescribing Ritalin to children for attention deficit hyperactivity disorder, Christchurch Press (17 March 2001), 6. The question of whether antipsychotic drugs are the right treatment for challenging behaviour in learning disability and a call for a randomised trial is made is JME 27 (2001), 338-43. School violence is discussed in JAMA 286 (2001), 605. Discussion of the use of antidepressants by children in the USA and Luxox is in Time (21 May 2001); NEJM 344 (2001), 1326-7. Exercise is one of the methods to counter depression, BMJ 322 (2001), 763-7. Also on depression, BMJ 322 (2001), 419-21, 482-4; NZMJ 114 (2001), 25-9; MJA 175 (2001), 19-23. A study of the association between delinquency and health is Brit. J. Health Psychology 6 (2001), 103-20. There are long delays in seeking treatment for schizophrenia, Lancet 357 (2001), 898-9. Boosting brain activity by magnetic fields is debated in Science 292 (2001), 1284-5.

Papers on the health dangers of smoking include: NatMed 7 (2001), 775-6, 833-9; Int. J. Epidemiology 30 (2001), 24-7; Science 293 (2001), 205; JAMA 286 (2001), 436+, 462-3; Lancet 358 (2001), 87, 115-9; BMJ 323 (2001), 752; AJOG 184 (2001), 934-5; AJMG 101 (2001), 246-54; AJPH 91 (2001), 1345. Association between tryptophan hydroxylase gene variant and smoking behaviour is reported in AJMG 105 (2001), 518-20. On nicotine replacements, Lancet 357 (2001), 897; 358 (2001), 512; BMJ 323 (2001), 1076-8. A passive smoking test case won in Australia, Lancet 357 (2001), 1511; BMJ 322 (2001), 1139. A US court awarded record damages in a smoking case, but it is being appealed, Lancet 357 (2001), 1958. Anti-tobacco campaigns are discussed in: Australia, MJA 174 (2001), 490-1, 512-5; China, AJPH 91 (2001), 1653-5; India, BMJ 322 (2001), 386; Italy, Lancet 358 (2001), 245; Switzerland, Lancet 357 (2001), 208; Spain, Lancet 357 (2001), 1026; the Netherlands, BMJ 322 (2001), 452; USA, AJPH 91 (2001), 1412-30; BMJ 322 (2001), 1129; NEJM 344 (2001), 1797-9. A survey among Japanese physicians of their smoking habits is JAMA 285 (2001), 2643-8. On tobacco and bete quid use in Taiwan, AJPH 91 (2001), 1130-4.

WHO has claimed that tobacco companies exploit women, BMJ 322 (2001), 1384. On the problems in developing countries, BMJ 322 (2001), 869; JAMA 286 (2001), 296; SSM 53 (2001), 199-213; Lancet 357 (2001), 1459. The Massachusetts Restaurant Association long supported the tobacco industry in fighting bans on smoking, AJPH 91 (2001), 598-603. A study of adolescent perceptions of smoking imagery in film is SSM 52 (2001), 1577-87. Advertising is discussed in AJPH 91 (2001), 1100-6. On young peoplefs awareness of tobacco marketing, BMJ 323 (2001), 513-7; and attitudes to smoking, SSM 53 (2001), 593-02. Sudden infant death syndrome and smoking is discussed in AJPH 91 (2001), 432-6. Dieting increases the risks of starting smoking in girls, AJPH 91 (2001), 446-50. On smoking links with anxiety disorders, JAMA 285 (2001), 732-3; Lancet 357 (2001), 1900-1, 1929-32. In Europe tobacco companies rigged standards used, NS (9 June 2001), 4. Philip Morris Company apologized for the claim in the Czech Republic that smokers who die actually save the government money in looking after old people, BMJ 323 (2001), 126. Use of tobacco money by universities is debated in BMJ 323 (2001), 1-2; BMJ 322 (2001), 1118-9, 1270; Science 292 (2001), 1055.

Canada has legalized the medical use of cannabis, BMJ 322 (2001), 948; 323 (2001), 68. The users must carry identification cars, Lancet 358 (2001), 220. Methods to allow the benefits of cannabis for pain control without bad effects of smoking it are discussed in NS (28 July 2001), 11; Nature 410 (2001), 613; BMJ 322 (2001), 691. A study on the medical use and misuse of opioids in India is Lancet 358 (2001), 139-43. In general on drug use, NEJM 345 (2001), 472; BMJ 322 (2001), 749-50; 323 (2001), 171; Nature 410 (2001), 376-80, 763-5; 412 (2001), 141; Science 292 (2001), 236-7, 2266-7; NS (23 June 2001), 52; SSM 53 (2001), 153-260.

WHO has shown alcohol misuse is sweeping the world, BMJ 322 (2001), 449; Lancet 357 (2001), 617. Increased alcohol is a risk factor for bicyclists also, JAMA 285 (2001), 2445-6. A study of genetic variation in alcohol dehydrogenase and how much alcohol is beneficial to health is in NEJM 344 (2001), 549-55. Also on alcohol and health, SSM 52 (2001), 863-70; Science 291 (2001), 2077-8; Lancet 357 (2001), 1299; MJA 174 (2001), 281-4; JAMA 285 (2001), 1965-70, 1971-7, 2716-7; SA (July 2001), 13. The question of whether laws can prevent drunkenness, using the Gin Acts in the UK is in AJPH 91 (2001), 375-84. Exposure to organic solvents may affect personality, Occup. Nviron. Med. 58 (2001), 14-8. People who drink more coffee may have decreased risk of Parkisonfs disease, Science 292 (2001), 1295. On caffeine, NEJM 344 (2001), 1256.

Europe has called for tighter controls on breast implants, Lancet 357 (2001), 2036. Also on implants, SSM 53 (2001), 147-8; Virginia Law Review 86 (2001), 801-34; J. Health Politics, Policy and Law 25 (2000), 992-4. It would be safer if women can grow their own, NS (26 May 2001), 7.

Fears of EMF radiation are discussed in BMJ 322 (2001), 574, 682; Lancet 357 (2001), 777; NS (10 March 2001), 7; AJPH 91 (2001), 1355-7; Network 16 (August 2001), 3-4. Headaches in cell phone users are discussed in Env. Health Perspectives 108 (2000), 1059-62. Radiation contamination is discussed in NS (3 March 2001), 12; (24 March 2001), 17, 19. Medical tests may have been refused to victims of nuclear testing in Australia, Australasian Science (July 2001), 37-41; (August 2001), 29-31. On dangers of radiative ammunition, Nature 410 (2001), 294. Intergenerational ethics in nuclear waste is debated in Risk Analysis 20 (2000), 763-70, 771+; AJPH 91 (2001), 1371-6.

The Ottawa Mine Treaty is discussed in Lancet 357 (2001), 731. On gun violence, NEJM 344 (2001), 1484-5. A review of deaths from house fires in the USA is NEJM 344 (2001), 1911-6. Child safety seats work as discussed in JSPN 6 (2001), 87-9. Cycle helmets have reduced injuries, BMJ 322 (2001), 1427-8. Letters on whether back belts prevent injury are in JAMA 285 (2001), 1151-2. Problems from working at video display terminals are discussed in Occup. Nviron. Med. 58 (2001), 267-71. Violence in nursing is discussed in Nursing Forum 36 (2001), 3-35.

A series of 3 papers on preventative ethics and methadone maintenance programs are in New Zealand Bioethics J. 2 (Oct. 2001), 7-36. A paper looking at the risk regulation using the Americans with Disabilities Act is in Columbia Law Review 101 (2001), 1479-513. A European health agency is being considered, Lancet 358 (2001), 2138. Monitoring the safety of over the counter drugs is discussed in BMJ 323 (2001), 706-7.

Statins have been called the new aspirin, BMJ 323 (2001), 1145. Aspirin and warfarin have no difference in stroke reduction over a two year course, NEJM 345 (2001), 1444-51; BMJ 323 (2001), 1204. On resistance to the drug gleevec, Science 294 (2001), 1834. Priority setting for new cancer drugs is discussed in Lancet 358 (2001), 1660, 1676-81. Ramipril may prevent some diabetes in high risk individuals, JAMA 286 (2001), 1882-5.

A review paper is Kass, NE. "An ethics framework for public health", AJPH 91 (2001), 1776-82. A paper asking whether terrorism should be a major target of WHO is in J. Health Care, Med. & Community 20 (2001), 12-16. A study of medical rehabilitation after the war in Croatia is in Croatian Medical J. 42 (2001), 556-64. On health behaviour in Eastern and Western Europe, SSM 53 (2001), 1621-30. Environmental determinants of physical activity in the USA are studied in AJPH 91 (2001), 1995-2003.

Smoking addiction is discussed in NS (10 Nov. 2001), 28-31; BMJ 323 (2001), 873. Films with smoking encourage young persons to smoke more, BMJ 323 (2001), 1378-9, 1394-7. WHO has called for tighter voluntary controls on tobacco, Lancet 358 (2001), 1615. On prevention of tobacco addiction, Lancet 358 (2001), 1973; AJPH 91 (2001), 1745-7; JAMA 286 (2001), 2732-7. India's Supreme Court has directed all states to place a total ban on smoking in public places, Lancet 358 (2001), 1620. On smoking among Japanese physicians, JAMA 286 (2001), 917. On the Tobacco settlement, NEJM 345 (2001), 504-11, 535-7. Australia is considering a law following a court award for passive smoking damage, Lancet 358 (2001), 738.

A British government report suggests a nuclear free Britain, NS (15 Dec. 2001), 3, 5. Ireland is taking legal action against the UK Sellafield reprocessing site, Lancet 358 (2001), 1517. On storage of nuclear waste at Yucca Mountain, Nature 412 (2001), 841, 850-2. A report into birth defects near a nuclear plant has not found evidence of birth defects, NS (17 Nov. 2001), 18. Leaks of plutonium from a Soviet factory may still be causing cancer, NS (27 Oct. 2001), 11. On reprocessing of plutonium, Science 293 (2001), 2397-8. There is new evidence of thyroid cancer 15 years after Chernobyl, Lancet 358 (2001), 1965-6; BMJ 323 (2001), 643-4. Trust in the nuclear industry is discussed in Environment 43 (7) (2001), 41-3; The Ecologist 31 (Sept. 2001), 20-3; NS (25 Aug. 2001), 3. The impact of EMF radiation and mobile phones is discussed in Science 294 (2001), 1440-2; Lancet 358 (2001), 1733. Also on radiation, JAMA 286 (2001), 2603.

On breast reconstruction, JAMA 286 (2001), 2163.

Rational use of analgesic drugs is called for in NEJM 345 (2001), 1844-5. Canadian drug prescribing is discussed in NatMed. 7 (2001), 983.

Chaperone overload might contribute to multifactorial diseases, TIG 17 (Dec. 2001), 701-4. Large differences in asthma prevalence can occur without large differences in atopy frequence, as shown in a UK, Albania comparison, Lancet 358 (2001), 1426-7. Also on asthma, Lancet 359 (2001), 599-600. Questions of how to distinguish good and bad responders to drugs are discussed in F&S 76 (2001), 1185-90.

A study of the genetic and environmental contributions to cannabis dependence is Psychological Medicine 32 (2002), 195-207. There is still controversy over whether cannabis damages the brain, NS (9 March 2002), 6. A book review on chemically altered consciousness is NatMed. 8 (2002), 12. The link between ADHD and addiction is discussed in NatMed. 8 (2002), 24-5. On drug use in children, NS (10 Nov. 2001), 28-31. On the legal penalties for drug use, NS (10 Nov. 2001), 3; (2 Feb. 2002), 44-5; JAMA 286 (2001), 1764-5. Glutamate may be useful to stop addiction, SA (Jan 2002), 18. MDMA and reversal of addiction is discussed in Lancet 359 (2002), 1831, 1864-9. A discussion of television addiction is SA (Feb. 2002), 62-8. Behavioural addictions are reviewed in Science 294 (2001), 980-2. Chinese children and addiction are discussed in Newsweek (3 Dec. 2001), 42-5. A book review on the global history of addiction is in Nature 414 (2001), 846-7.

The International Space Station will not allow alcoholics, Nature 415 (2002), 568. The link between alcohol and breast cancer is discussed in JAMA 286 (2001), 2143-51. Suicide is one of the major risks of alcoholism, BMJ 323 (2001), 817-8.

A UK study has found microwave emissions like those from a mobile phone may make worms more fertile, which had led to calls for more tests on the safety of mobile phones, NS (9 Feb. 2002), 4-5.

A discussion of the lengthy delays in approval for Sellafield nuclear reprocessing plant is Newsweek (11 Feb. 20002), 42-3. Some DNA mutations have been linked to Soviet atom bomb tests, Science 295 (2002), 946.

The dangers of violence to nurses is discussed in BMJ 323 (2001), 1362-4, 1472-3. On suicide, JAMA 286 (2001), 3089+, 3120+, 3126-7.


Individual responsibility for health is argued in HCR 32 (March 2002), 22-31. Frequent involvement in cognitively stimulating activities reduces risk of Alzheimer disease, JAMA 287 (2002), 742-8.

Genetic susceptibility to tobacco smoke toxicity is discussed in Geriatrics & Gerontology International 2 (2002), 1-7. Progress in understanding nicotine receptors is described in NatMed. 8 (2002), 447-9.

Peace and public health, and the Skopje Declaration on Public Health, Peace and Human Rights (Dec. 2001) are discussed in Croatian Medical J. 43 (2002), 103-125.

A series of papers on public health ethics is in JLME 30 (2002), 136-304. A review of potential uses of thalidomide is Croatian Medical J. 43 (2002), 274-83. The questions of making drugs taste nice is discussed in NS (6 July 2002), 12. They may taste too nice so that they are eaten like candy by children.

The safety of mobile telephones is discussed in NS (29 June 2002), 16. WHO has linked smoking to passive cancer, The Guardian (20 June, 2002).

A new law in Germany will compensate patients for side effects of drugs, Lancet 360 (2002), 471. Side effect prevention requires cooperation between doctors and pharmacists, JAMA 287 (2002), 586-7. The Kenyan Medical Association is drawing up guidelines to end inappropriate use of painkillers, Lancet 359 (2002), 1927. Aspirin may decrease mortality from stroke, Lancet 360 (2002), 232; NEJM 346 (2002), 1468-74, 1800-6. Anastrozole can be useful for breast cancer, Lancet 360 (2002), 2126, 2131-9. The American Dental Association has recommended that amalgam fillings should not be removed, Lancet 360 (2002), 393. Traditional medicine has been recognized in Ghana, Lancet 359 (2002), 1760. Self medication in Vietnam is reviewed in SSM 54 (2002), 1875-86. Trends in medication use in the USA are discussed in JAMA 287 (2002), 1804-5. On acupuncture safety, BMJ 325 (2002), 170-1. Alternative medicine is being called for in the USA, Lancet 359 (2002), 1213.

Drug testing on children is discussed in Science 296 (2002), 1609-11. The US FDA on 31 June 2002 amended its new drug and biological product regulation so that human drugs and biologics that are intended to reduce or prevent serious or life-threatening conditions may be approved for marketing based on evidence of effectiveness from appropriate animal studies when human efficacy studies are not ethical or feasible, so as to help cope with terrorist threats, HCR 32(4) (2002), 9. On FDA's drug review, FDA Consumer (July 2002), 19-24. The FDA will have closer ties to industry, Lancet 359 (2002), 1923. The use of generic medicines in Transition Economies is discussed in Croatian Medical J. 43 (2002), 462-9.

Ethical issues in occupational health and ionizing radiation damage are discussed in Science and Engineering Ethics 8 (2002), 139-54. A study of immigrants from Chernobyl in Israel is SSM 54 (2002), 309-17. Improving the health of workers in indoor environments is called for in AJPH 92 (2002), 1430-40. A study finding no evidence that the quality of air in aircraft increases risk of the common cold is JAMA 288 (2002), 483-6. A study on venous thrombosis on long flights has been difficult, Nature 417 (2002), 4. Mitsui company in Japan agreed after 17 years to compensate workers in a black lung disease case, Lancet 360 (2002), 471.

A series of papers on the ethical issues in facing the human deaths and disturbances to society in Gujarat, India are in Issues in Medical Ethics 10 (July 2002), 43-51. The impact of war on quality of life in Croatia is discussed in Croatian Medical J. 43 (2002), 396-402. Rubber bullets are not a safe method of crowd control, and result in deaths, Lancet 359 (2002), 1795-800. A comparison of annual deaths from traffic accidents in children is BMJ 324 (2002), 260.

Lifestyle interventions to reduce diabetes are called for in BMJ 325 (2002), 403-4. Injury risks are less if exercise is done, BMJ 325 (2002), 451-2. Lifetime intervention was more effective than metformin in reducing diabetes incidence, NEJM 347 (2002), 393-403. Exercise capacity is a predictor of mortality in men, NEJM 347 (2002), 793-801. On exercise, SSM 54 (2002), 607-19. Overweight people are less likely to survive a car crash, NS (30 March 2002), 9.

Cancer incidence in the USA could double by 2050, Lancet 359 (2002), 1755. The dangers of sitting in the sun are discussed in Lancet 360 (2002), 351. Safety and efficacy of new cancer drugs is discussed in BMJ 324 (2002), 269.

EMF radiation has been linked to leukemia in a Japanese study, Japan Times (26 Aug. 2002). In Japan a lip reading unit may allow people to only mouth the words into cell phones (to avoid disturbing others), NS (6 April 2002), 19.

A call for a human right to adequate housing is AJPH 92 (2002), 712-5, 733-8. Ethics in public health is discussed in Lancet 360 (2002), 416; JAMA 287 (2002), 381-2. The McKeown hypothesis and ethics is discussed in AJPH 92 (2002), 722-32.

The dangers of ecstasy are discussed in NS (20 April 2002), 26-33. Depression screening is called for in the USA, Lancet 359 (2002), 1836. On depression in children, BMJ 325 (2002), 229-30. Psychiatry and stigmatization is discussed in JAMA 287 (2002), 1856. Placebo studies in depression are highly variable, JAMA 287 (2002), 1807, 1840-7, 1853+.

Ethics and medical marijuana are discussed in HCR 32 (Sept. 2002), 11-3. The challenges of integrating complementary and alternative medicine for research ethics committees are discussed in BME 180 (2002), 13-6. Medicinal plants are discussed in JAMA 288 (2002), 1706-7. On ethnicity and environment and health, SSM 55 (2002), 1647-61. Simple measures could increase life expectancy by 5-10 years, BMJ 325 (2002), 985. The responsibility for sanitation is discussed in SSM 55 (2002), 1539-51.

Reporting adverse effects of drugs is discussed in NEJM 346 (2002), 1633-7; Lancet 360 (2002), 1435. Immune monitoring could be also improved, TIBTECH 20 (2002), 495-7. Patient reps can help review products, FDA Consumer (Jan. 2002), 10-17. There has been criticism of the FDA in allowing paracetamol to be widely used despite 450 deaths a year from overdoses, BMJ 325 (2002), 678. The efficacy and safety of Cox 2 inhibitors are discussed in BMJ 325 (2002), 607-8, 980-1. Tamoxifen reduces breast cancer by a third in high risk women, BMJ 325 (2002), 613. The FDA is concerned that more deaths will come from the relauch of Lotronex drug, BMJ 325 (2002), 561. Work stress is discussed in BMJ 325 (2002), 857-60. Warfarin is useful to prevent future heart attacks in addition or instead of aspirin, NEJM 346 (2002), 969-74. Aspirin is safe to use, NEJM 346 (2002), 1309-17.

On ethics, Callahan, D. & Jennings, B., "Ethics and public health: Forging a strong relationship", AJPH 92 (2002), 169-76. On enhancing public safety in primary care, BMJ 324 (2002), 584-7.

Ecstasy may be useful in treating Parkinson disease, NS (9 Nov., 2002), 14.

The Health Council of the Netherlands has concluded that there is not a health risk from mobile phones, Network 17 (June 2002), 9-10. A Maryland judge rejected a cell phone case, Science 298 (2002), 338.

The health risks from war and sanctions in Iraq are discussed in Lancet 360 (2002), 1031. The question of whether the Afghan war was a just war is raised in BMJ 324 (2002), 353-5. Damages from football to brain are being examined more, JAMA 287 (2002), 437-40. A study of Nordic airline pilots over 5 decades found no increased cancer rate, BMJ 325 (2002), 567-9. A case of major radiation exposure is discussed in NEJM 346 (2002), 944-7.

A series of papers on Public health and the Law are in JLME 30 (Fall 2002), Special Supplement, pp. 3-217.

Chinese traditional medicine is being modernized, Science 299 (2003), 188-90. A comparison of the efficacy and cost-effectiveness of drug and psychological treatments for common mental disorders in Goa, India found drugs worked better, Lancet 361 (2003), 33-9. The doses of inhaled steroids for children may be too high, BMJ 325 (2002), 1261.

Nicotine may promote tumour growth, Lancet 361 (2003), 146. The EU is proposing a total ban on tobacco advertising, BMJ 325 (2002), 1260.

A paper on the ethical issues is Dupont, BM., "The ethics of innovative medicine: From the possible to the permissible?", Biology International 43 (Dec. 2002), 11-6. Ethics of electroconvulsive therapy is discussed in Issues in Medical Ethics 11 (2003), 9-12. Taxomifen can reduce the risk of breast cancer, Lancet 361 (2003), 296-300.

The safety of marijuana and other drugs is discussed in JAMA 289 (2003), 427, 482-3. The WHO issued a revised draft of its Framework on Tobacco Control on 15 January 2003 that makes the demands softer and no longer includes a total advertising ban on cigarettes, Lancet 361 (2003), 315, 611-2. The cardiotoxicity of smoking appears not to be linked to apolipoprotein E genotype, Lancet 361 (2003), 396-8. On the dangers of cigarettes, Lancet 360 (2002), 1033-4.

A study suggesting use of low dose budesonide for asthma treatment is Lancet 361 (2003), 1066-7, 1071-6. The damages from compensation claims against Bayer for cerivastatin are discussed in Lancet 361 (2003), 793.

A letter criticizing the Russian government for use of anesthetic drugs in the Moscow theatre terror case is Lancet 361 (2003), 1131.

A clinical trial of treating depression in low income women in Chile showed good response, Lancet 361 (2003), 995-1000. On the safety of electroconvulsive therapy in depressive disorders, Lancet 361 (2003), 799-808. Suicide prevention in Japan is discussed in Lancet 361 (2003), 882.

A study of health risk behaviour and socio-economic status and health on Slovak adolescents is Croatian Medical J. 44 (2003), 41-9.

The tobacco-control treaty and its language are discussed in Lancet 361 (2003), 839-40. A further affect of nicotine on macrophages is described in Lancet 361 (2003), 1069-70.

The alcohol limit in breath in Japan is 0.15mg/L and the stricter limit since June 2002 has reduced the number of alcohol-related traffic deaths to 8326 persons in 2002, the lowest number in 25 years, Lancet 361 (2003), 1132.

On the dangers of herbal supplements like kava kava, NatMed. 9 (2003), 634-5. There are differences in mercury levels in the hair of children with autism, NS (21 June 2003), 4.

An article on the impact of conflict and war on nursing and ethics is Nursing Ethics 10 (2003), 354-67.

The ethics of drug use are discussed in Pollard, I. "From happiness to depression", Today's Life Science (Australia) 15(4) (July 2003), 22-6. There still may be a place for street drugs in clinical research, NS (9 Aug. 2003), 26.

Papers on pharmacogenomics and clinical trials are in Clinical Evaluation (Rinsho Hyoka) 30 (2003), Suppl. 19, 308pp. The duties of doctors to provide information about alternative medicine is discussed in J. Law & Medicine 10 (2003), 271-84, 296-307. Integration of European and Western medicine is discussed in European Review 11 (2003), 225+.

Faster healing with fewer scars is reported from initial trials of Renevo, NS (4 Oct. 2003), 10. The early cessation of the trial of letrozole after tamoxifen is debated in BMJ 327 (2003), 885. On the greatest threat to women's health, Lancet 362 (2003), 1165. On cancer treatment, NS (23 Aug. 2003), 36-9. The NIH is developing more drug discovery work, Science 302 (2003), 218-20. On the dangers of drugs, NS (25 Oct. 2003), 38-40. Drugs for coronary artery disease are reviewed in Nature 425 (2003), 902. A drug PTC124 may cure cystic fibrosis, NS (18 Oct. 2003), 16. An indigenous cure for diabetes is discussed in NatMed. 9 (2003), 1228. The idea that a small amount of a toxin may help our health is being reexamined, Science 302 (2003), 376-9.

Attempts to stop doping in sports are discussed in NS (4 Oct. 2003), 23; Nature 425 (2003), 752. The pursuit of happiness and drugs is discussed in NS (4 Oct. 2003), 40-7; NS (11 Oct. 2003), 36-41. On marijuana as a drug, NatMed. 9 (2003), 1227; Nature 425 (2003), 756. Cocaine and heroin use limits the ability of brain cells to make new connections, NS (30 Aug. 2003), 14. After effects of ecstasy are discussed in Nature 425 (2003), 109, 223; NS (13 Sept. 2003), 5. Altered sleep patterns affect many persons, Nature 425 (2003), 896-8. Hypochondria is discussed in Time (13 Oct. 2003), 42-3. On use of lithium as a drug, Nature 425 (2003), 118-20.

Voluntary measures can reduce exposure to dioxins in diet, EST 37 (2003), 316-7A. (See also Environment News section). Rebates have been offered to reduce lead poisoning in hunters in US, to those who use non-lead bullets, Los Angeles Times (28 Sept. 2003), B10.

A review after 80 years of the Slovenian Institute of Public health is in Croatian Medical J. 44 (2003), 511-9. Urban health is discussed in Lancet 362 (2003), 1091-2. A piano to stop repetitive stress disorder is discussed in SA (Oct. 2003), 16-7.

The impacts of radioactive waste on health are discussed in Croatian Medical J. 44 (2003), 520-33.

Discussion of the safety of cellphones is in NS (13 Sept. 2003), 12-3, 46-9; (26 Oct. 2003), 9. Radiowaves from phone masts can be used to track cars and traffic, NS (25 Oct. 2003), 23.

A series of papers in Japanese on regulation of clinical trials in US, Europe and Asia are in Rinsho Hyoka (Clinical Evaluation) 31 (2004), 248-484. On ethics of internet pharmacies, HCR 34 (March 2004), 15-7.
A paper on the ethical and social issues of cosmetic surgery is in HCR 34 (March 2004), 3, 18-29.

Patenting & Business
The ethics and law of the EU biotechnology directive are discussed in Law and the Human Genome Review 19 (July 2003), 187-206. On patenting life, J. International Biotechnology Law 1 (2004), 20-7. The use of copy protection or terminator technology in seed protection is reviewed in Technology Analysis & Strategic Management 16 (2004), 121-41.
A European patent that gave a company in Utah the exclusive right to perform diagnostic tests for a breast-cancer gene has been revoked. In a ruling on 18 May 2004, the European Patent Office (EPO) granted an appeal against Myriad Genetics of Salt Lake City over its patent on the gene BRCA1. The office ruled that Myriad's claim was invalid because its original submission, made in the United States in 1994, contained a number of small errors in the gene's sequence.
The regulation of drugs and clinical trial abuses in India are discussed in Indian J. Medical Ethics 1 (2004), 2-5, 11-21. Some local governments in the USA have been buying cheaper drugs in Canada, BMJ 327 (2003), 1126; JAMA 290 (2003), 2921-5. European prices are also cheaper, Economist (31 Jan. 2004), 53-4. Counterfeit drugs are discussed in NEJM 350 (2004), 1384-6. On ethical issues, Miller, FG. Et al. "Ethical issues concerning research in complementary and alternative medicine", JAMA 291 (2004), 599-602. Trade in traditional medicines is discussed in NatBio 22 (2004), 263-5; SA (Dec 2003), 26. The trade is causing degradation of biodiversity, NS (10 Jan. 2004), 10-1. Ethics of public health surveillance is discussed in Science 303 (2004), 631-2.

The drug Lipitor has been linked to amnesia, NS (6 Dec. 2003), 14. A website that links the way genes influence drugs is www.pharmgkb.org, Science 303 (2004), 443. On monitoring drug treatment, BMJ 327 (2003), 1179-81, 1222-5. Doctors continue to use treatments that do not work, BMJ 328 (2004), 474-5. The health impact of the first Gulf War are discussed in BMJ 327 (2003), 1357-8. Psychiatric drugs are discussed in NEJM 349 (2003), 2369-71. On statins, JAMA 290 (2003), 2243-5; Lancet 362 (2003), 1498; BMJ 328 (2004), 400-2, 500-1. A review of aspirin is NS (7 Feb. 2004), 36-9.

Lifestyle change to alter risk of diabetes is useful, BMJ 327 (2003), 1120-1. Ethics of recommending lifestyle change is discussed in JAMA 290 (2003), 2660-1. Self-poisoning with pesticides is reviewed in BMJ 328 (2004), 42-4. Tests on pesticide safety on humaNS may be conducted in USA now, Science 303 (2004), 1272; Nature 427 (2004), 770-1. On occupational safety, Lancet 363 (2004), 673-4; JAMA 290 (2003), 3069-70. Pet ownership and health is discussed in MJA 179 (2003), 460-1. On the hygiene hypothesis, Nature 428 (2004), 354. Asthma rates are increasing, NS (27 March 2004), 36-9. On stress in cities, Science 303 (2004), 463.

A Netherlands Health Council report is addressing the impact of passive smoking, Network 19 (March 2004), 8-12.

On the dangers of ionizing radiation in medicine, BMJ 327 (2003), 1166-7; 328 (2004), 19-21; Lancet 363 (2004), 340; NS (6 March 2004), 10. A medical response to nuclear incidents is prepared in BMJ 328 (2004), 568-72. On risks of cancer from mobile phones, BMJ 328 (2004), 124, 292. A Swedish study of extremely low frequency magnetic fields suggests dangers from welding, Epidemiology 14 (2003), 420-6. There is little new evidence that EMF fields are harmful, Network 19 (March 2004), 27-8.

Traffic safety is discussed in Bulletin WHO 81 (2003), 916-7; NS (13 Dec. 2003), 23; BMJ 327 (2003), 1455-6. An international study on depiction of old persoNS on traffic sigNS is BMJ 327 (2003), 1456-7.

A discussion of EU clinical trial directives and their extension into UK regulations is in BME 196 (2004), 1, 6-11; Lancet 363 (2004), 1204. Availability of Canadian drugs helps save money for some US consumers, NEJM 350 (2004), 1155; Lancet 362 (2003), 1816; BMJ 327 (2003), 1397-400. On US drug regulation, NEJM 350 (2004), 2220-1; JAMA 291 (2004), 2183. Drug prescribing in New Zealand is reviewed in NZFP 30 (2003), 395-400, 401-4. E-drugs is a growing way to receive drugs, MJA 180 (2004), 103, 118-9. Drug counterfeiting is discussed in Lancet 362 (2003), 301. Aspirin use is discussed in NEJM 350 (2004), 114-24; Lancet 362 (2003), 1558; JAMA 291 (2004), 2433-40. Exemestane or letrozole treatment after tamoxifen treatment helps long-term survival after breast cancer, NEJM 350 (2004), 1081-92; 1793-802. Statins are discussed in MJA 180 (2004), 229-31; BMJ 328 (2004), 385-6; Lancet 363 (2004), 1570. From July 2004 simvastatin is available over the counter in the UK, Lancet 363 (2004), 1659; BMJ 328 (2004), 1221.

Drug delivery is discussed in Lancet 362 (2003), 1984-5. Similar drug names is dangerous, JAMA 291 (2004), 1948-9. Drug companies should provide all information to consumers, NS (1 May 2004), 3. A global review of injections is in BMJ 327 (2003), 1075-8.  A review of chemigenomics, is Nature Reviews Genetics 5 (2004), 262-75. Melatonin is suggested for some children with sleep disorders, JMG 40 (2003), 793-6. A review of orphan products is FDA Consumer (Nov. 2003), 10-15. A Spanish medical editor has won a case for free speech against Merck, BMJ 328 (2004), 188, 307. Pfizer pleaded guilty to illegally promoting off label uses of the drug gabapentin, but the drug is still selling more, BMJ 328 (2004), 1217. A review article is Wingfield, J. et al. "The scope of pharmacy ethics – an evaluation of the international research literature, 1990-2002", SSM 59 (2003), 2383-96. Registering clinical trials is a new role for WHO, Lancet 363 (2004), 1413-4; Bulletin WHO 82 (2004), 321, 397.

Reduction of particulate air pollution has been shown to reduce risk of heritable mutations in mice, Science 304 (2004), 1008-10. FDA guidance on pharmacogenomics data submission is explained in Nature Reviews Drug Discovery 2 (2003), 937-8. Genetic testing is being used for some pharmaceutical prescribing, Science 303 (2004), 443. Molecular determinants of resistance to antiandrogen therapy are reviewed in NatMed. 10 (2004), 33-9. A technique for non-invasive tracking of pharmacodynamics of a targeted drug has been made, NatBio 22 (2004), 701-6. EGFR mutations in lung cancer have been correlated to Gefitinib therapy, Science 304 (2004), 1497-500. Overall in the USA about 1 in 12 persons are prescribed the wrong drug, BMJ 328 (2004), 424; Archives Internal Medicine 164 (2004), 305-12.

Ethical issues in research into alternative medicine are discussed in JAMA 291 (2004), 2192-4. A book review of Christian Science on Trial is NEJM 349 (2003), 2574-5. Tests have found Echinacea was not effective in children aged 2-11 years in treating respiratory infections, and actually led to rashes, JAMA 290 (2003), 2824-30. Ginkgo did not help mountain sickness, BMJ 328 (2004), 797-9. Acupuncture can be cost effective for headache management, BMJ 328 (2004), 744-7, 747-9. Curcumin, a component of turmeric, corrects cystic fibrosis defects, Science 304 (2004), 600-2. African American skepticism of psychiatric medication is reported in J. Health & Social Behavior 44 (2003), 506-24. A review of medical practices in Arabia is SSM 58 (2004), 697-702. Israeli patients dissatisfaction with non-conventional medicine is discussed in SSM 58 (2004), 2421-9. Modernized education of traditional medicine in Korea is making it professional, SSM 58 (2004), 1999-2008. A Chinese herbal medicine, artemisin from sweet wood (qinghaosu) is being used to treat malaria, Int. Herald Tribune (10 May 2004). A comparison of massage versus drugs for back ache is in Newsweek (10 May 2004), 40-3.

Discussion of Viagra is in NatMed. 9 (2003), 1453. More trials are urged before testosterone therapy is approved, NEJM 350 (2004), 482-92; Lancet 362 (2003), 1725. The medicalization of compulsive buying is discussed in SSM 58 (2004), 1709-18. The question of whether to enhance rather than just treat using neurological drugs is addressed in Science 304 (2004), 17. Cosmetic surgery is discussed in BMJ 328 (2004), 1208; Nature 429 (2004), Newsweek (17 May 2004), 42-3. Learning to forget bad experiences through medical treatment is reviewed in Science 304 (2004), 34-6. The role of many species in the ecosystem is discussed in Science 303 (2004), 1305-7. Diarrhoea in children is discussed in Lancet 363 (2004), 641-53.

The effects of dietary magnesium on type 2 diabetes risk are discussed in JAMA 291 (2004), 1056-7. Higher iron store is also a risk factor, JAMA 291 (2004), 711-7. It is associated with decreased cognitive function in age, BMJ 328 (2004), 548-51. The hygiene hypothesis is discussed in Nature 428 (2004), 354. Early infections do not appear to protect against atopy, BMJ 328 (2004), 1223-6. Asthma may have peaked in Melbourne, Australia, MJA 180 (2004), 273-6. Susceptibility loci for asthma are discussed in Science 304 (2004), 300-4 (see also Genetic Disease Markers News). Asthma may be linked to indoor dampness, Science 304 (2004), 1229. Pumiliotoxins are still difficult to identify, PNAS 101 (2004), 7841-2. Resilence of communities in emergencies helps all survive, NS (8 May 2004), 19. The rescuers at the World Trade Center have respiratory problems, Lancet 363 (2004), 1614. Aircraft noise around Schipol airport has health affects, Occup. Environ. Med. 61 (2004), 405-13.

There are doubts over the use of antidepressants in children, Lancet 363 (2004), 1335; Nature 427 (2004), 474; NatMed. 10 (2004), 439. A study of social factors in Pakistan associated with depression is BMJ 328 (2004), 794-7. Too high testosterone can inhibit social skills and may be linked to autism, NS (2004). Content analysis of video games is presented in JAMA 291 (2004), 856-65. QOL is perceived differently by different persons in South Africa, Bulletin WHO 82 (2004), 206-12. Multiple sclerosis is exacerbated by stressful life events, BMJ 328 (2004), 731-3.

The burden of chronic disease is reviewed in Science 302 (2003), 1921-2. In general on public health, NEJM 350 (2004), 627; BMJ 328 (2004), 293; Lancet 363 (2004), 745, 1551-3; AJPH 94 (2004), 705-9; Bulletin WHO 82 (2004), 322; JAMA 290 (2003), 2336. Antibiotic use is associated with some increase in breast cancer, JAMA 291 (2004), 827-35.

Smoking remains the leading cause of mortality in USA in the year 2000, JAMA 291 (2004), 1238-45.

The risk of cancer from diagnostic X-rays is estimated in Lancet 363 (2004), 340, 345-51. Most doctors underestimate the radiation doses, BMJ 327 (2003), 371-2. Some persons have been extracting radioactive materials around Russia and there are fears they are being used for construction of dirty bombs, Science 302 (2003), 1644-5. Mobile phone radiation and health is discussed in NS (10 April 2004), 13; Ecologist (March 2004), 12.

Smoke exposure from fires for cooking is a major source of mortality, NS (6 Dec. 2003), 22; Lancet 362 (2003), 1902; BMJ 328 (2004), 787. A call for better exercise is made in Bulletin WHO 81 (2003), 827-30.  Pain is a common cause of work loss in the USA, JAMA 290 (2003), 2443-54. The US has not signed the landmine treaty still, Lancet 363 (2004), 788. Suicide prevention in the USAF is reported in BMJ 327 (2003), 1376-8. Gulf War illness is still unknown in cause, BMJ 327 (2003), 1370-2, 1373-5. On mental health of persons who kill strangers, BMJ 328 (2004), 734-7. Motorcycle visibility is a major factor in traffic deaths, BMJ 328 (2004), 857-60. Overall one million persons die each year on roads, BMJ 328 (2004), 851; www.who.int/world-health-day/2004; BMJ 328 (2004), 845, 888-90, 895; SSM 59 (2004), 405-14. High speed increases death rates by Newtonian physics, AJPH 94 (2004), 568-74.

On the risks of venous thrombosis after long haul air travel, BMJ 327 (2003), 1072-5. Occupational asbestos exposure is a risk factor for retroperitoneal fibrosis, Lancet 363 (2004), 1422-6. Factories injuries used to be more common, AJPH 94 (2004), 540. The general risks of work on health are discussed in Lancet 363 (2004), 1173; SSM 58 (2004), 449-61; 1137-46. Safety for vibration devices is discussed in Occup. Environ. Med. 61 (2004), 387-97. IBM has blocked publication of results of studies showing the mortality from chemicals in the chip industry, Science 304 (2004), 937-8. Occupational class is associated with physical activity in Japanese employees, SSM 57 (2003), 2281-9. Physical activity is skill not taken enough anywhere BMJ 328 (2004), 1089-90. Japanese persons have been advised to improve health habits, Lancet 363 (2004), 1126. Brain injury associated with heading in soccer is reviewed in BMJ 327 (2003), 351-2.

Many persons risk skin cancer from seeking suntans, BMJ 328 (2004), 786. On marriage and well being, J. Health & Social Behaviour 44 (2003). Promoting adequate sleep is important, JAMA 291 (2004), 2415-7.

Regulation of drug safety is discussed in Lancet 363 (2004), 2199; Nature 430 (2004), 401-2, 727-8; 431 (2004), 122-4; JAMA 292 (2004), 742-3; BMJ 329 (2004), 188; NatMed. 10 (2004), 773. The regulation of over-the-counter drugs is discussed in BMJ 329 (2004), 182-3. The benefits and risks have to be balanced, BMJ 329 (2004), 1-5, 41-4. Adverse drug reaction detection is discussed in BMJ 329 (2004), 44-7, 47-9.Papers from the 4th Kitasato University – Harvard School of Public health Symposium on "Advanced and Global Drug Development Techniques" are in Clinical Evaluation 31 Suppl. XX 2004, 329pp (in English and Japanese). On drug marketing, NatMed. 10 (2004), 655. Electronic prescribing is being developed in the UK, BMJ 328 (2004), 1453. Drug trials in India are discussed in SA (Aug. 2004), 14.  The US is licensing some drugs made in Cuba, NatBio 22 (2004), 1065. A discussion of efforts to make Japan the safest country in the world are in Asia-Pacific Perspectives Japan 2 (July 2004), 6-23.

Ethics of traditional medicines are discussed in JME 30 (2004), 156-9. Regulation and development of alternative and complementary medicine is discussed in MJA 180 (2004), 585-9, 645-6, 647-8; Sociology of Health & Illness 26 (2004),216-41. A book review of Principles of Medicine in Africa, 3rd edition, is in Lancet 364 (2004), 2197; see also a paper in EJAIB (Sept. 2004). Spirituality and QOL is discussed in Sexuality, Reproduction & Menopause 2 (2004), (2004), 76-82; BMJ 329 (2004), 123-4. An Indian court case challenging a traditional Indian remedy is described in BMJ 329 (2004), 1457. A comparison of traditional healers' medicinal plant knowledge in the Bolian Andes and Amazon is in SSM 59 (2004), 837-49. A plant mimic may be a cure for malaria, NS (21 Aug. 2004), 15. Medical acupuncture in Germany is reviewed in Sociology of Health & Illness 26 (2004), 351-72.

On cultural beliefs about medicines, SSM 59 (2004), 1307-13. Language use in public health is discussed in Lancet 363 (2004), 2190-1. Hand washing could save millions of lives, Bulletin WHO 82 (2004), 631-2. Cleanliness in Hospitals and MRSA infections are discussed in Lancet 364 (24 July 2004). Non-compliance with doctors suggestions are discussed in Lancet 363 (2004), 2004. Asthma has been linked to antibiotics, NS (5 June 2004), 13. Lifestyle rather than genes may be the main cause of myopia, NS (10 July 2004), 12. Pain killers may reduce male sex drive, NS (29 May 2004), 9. A book review of Aspirin is NS (7 Aug. 2004), 50.

The dangers of working in the electronics industry and IBM is discussed in Science 305 (2004), 309, 340-1. Flame retardants accumulate in persons bodies, Science 304 (2004), 1730.  Noise from airports is discussed in Lancet 364 (2004), 646-8. Active noise can quieten noisy environments, NS (29 May 2004), 22-3. Occupational safety and health programmes in Australia are assessed in Occupational & Environmental Medicine 61 (2004), 651-60. Health impacts from clean up after 9/11 are discussed in JAMA 292 (2004), 914-5. On environmental hazards, Lancet 363 (2004), 2007. Some causes of death are modifiable behavioural factors, JAMA 291 (2004), 2941-3. On ethics and  public health in general, AJPH 94 (2004), 928-31. Long working hours are discussed in JAMA 292 (2004), 25-6; SSM 59 (2004), 1719-30. Worker health and gender is compared in SSM 59 (2004), 1287-95. Motor vehicle license renewals for older drivers are discussed in JAMA 291 (2004), 2840-6. In general on public health, Lancet 363 (2004), 2084-6; Amer. J. Med. 117 (2004), 219-27.

The policy to allow over the counter statins is debated in Greehealthwatch 7(2, 2004), 1-2; Lancet 364 (2004), 411-3; JAMA 292 (2004), 317-8. Statin therapy appears safe in children with familial hypercholesterolemia, JAMA 292 (2004), 331-7, 377-8. On pharmacogenetics and safety, Nature Reviews – Genetics 5 (2004), 645-56; Science 304 (2004), 1458-60. Socioeconomic differences affect participation in cancer screening participation, SSM 59 (2004), 249-61. The use of tamoxifen is discussed in O&G 104 (2004), 431-2, 433-42. The dangers of medical radiation are discussed in MJA 180 (2004), 548-9; Lancet 363 (2004), 1908-11, 2192-3. No association between cellular telephones and salivary gland tumours was reported in Occup. Environmental Medicine 61 (2004), 675-9.

Abuse of drugs in sport is discussed in NS (14 August 2004), 3, 6-7; NatBio 22 (2004), 1069-71; Nature 430 (2004), 143-4, 602, 713; BMJ 329 (2004), 407; Science 305 (2004), 573. Lactic acid can also enhance performance, Science 305 (2004), 112-3. The limit to physical exertion is in the brain not the body, NS (31 July 2004), 11. Athletes are on the edge of normal physiology, Nature 430 (2004), 603.  Mandatory drug testing of high school athletes in USA is debated in Amer. J. Bioethics 4 (Winter 2004), 25-31; 41-3. On cosmetic surgery, JAMA 292 (2004), 743-5; and body images, BMJ 329 (2004), 237.

A study of alcohol  drinking in Slovenia is Croatian Medical Journal 45 (2004), 466-72; and in Brazil, SSM 59 (2004), 709-20. Alcoholism is a medical problem, Nature 429 (2004), 691; with genetics links, NatGen 36 (2004), 681. Studies of drug addiction and recovery are discussed in Nature 431 (2004), 394-5; Science 305 (2004), 1014-7. Cannabis for medical purposes is discussed in Lancet 364 (2004), 315-6; Nature 430 (2004), 492. A call to medicalise the suffering from depression in the developing world is made in Lancet 364 (2004), 233-4. Urban environments may also be risk factors, Lancet 363 (2004), 2012-3. SSRIs and suicide are discussed in JAMA 292 (2004), 338+, 379-81. The need for better health information in Africa is connected to general expansion to the Internet, Lancet 364 (2004), 222-4, 295+. The role of glossy magazines as information sources is discussed in BMJ 328 (2004), 1444. On self-reported health, SSM 60 (2004), 595-607.

Child public health is discussed in BMJ 328 (2004), 1384; 329 (2004), 266-9; MJA 180 (2004), 562-5. Youth mortality is discussed in JAMA 292 (2004), 569, 624-5. Peace and health are discussed in Lancet 364 (2004), 311, 384-6. Violence against healthcare workers is discussed in Occupational & Environmental Medicine 61 (2004), 649. Pain is often neglected in war areas, BMJ 328 (2004), 1398. Gulf war syndrome is discussed in Nature 430 (2004), 821. Depression in Afghanistan is discussed in JAMA 292 (2004), 575-84. Rapid income growth has affected diet quality in China, SSM 59 (2004), 1505-15.

On average smoking shortens life about 10 years, Bulletin WHO 82 (2004), 632-3; BMJ 328 (2004), 537-8, 1507, 1519-33, 1529; NS (5 June 2004), 12. Tobacco smoking policy by patients in Israeli hospitals is discussed in Nursing Ethics 11 (2004), 472-8. Passive smoking is discussed in JAMA 291 (2004), 2690-1; BMJ 328 (2004), 1222; 329 (2004), 200-4; NS (10 July 2004), 15. The WHO Convention on Tobacco Control may be international binding law by the end of 2004, Bulletin WHO 82 (2004), 635. Smoking bans are discussed in BMJ 328 (2004), 1379-80; 329 (2004), 368; NEJM 350 (2004), 2231-3; Occup. Environ. Med. (2004), 383-6. The UK ban on smoking ads might lead to other ad bans for other harmful substances, BMJ 328 (2004), 1558-60, 1572; Science 304 (2004), 804. Japan Tobacco's SmoCar for smokers is discussed in BMJ 329 (2004), 352. Teenagers images of tobacco use in Sweden are presented in SSM 59 (2004), 573-83; and in India, SSM 59 (2004), 415-31. Tobacco harm in south Asia is discussed in BMJ 328 (2004), 780. Kenya has proposed a tobacco compensation law for smokers to sue companies, Lancet 363 (2004), 1963.

Addiction has several causes, Feng, Y. et al. "A common haplotype of the nicotine acetylcholine receptor alpha4 subunit gene is associated with vulnerability to nicotine addiction in men", AJHG 75 (2004), 112-21; JAMA 292 (2004), 321-2. There is still a future for the cigarette, Lancet 364 (2004), 231-2. Medical benefits of nicotine are discussed in NatMed. 10 (2004), 660-1. Many secret documents from the tobacco industry will be on the Internet soon, BMJ 328 (2004), 1335. UK universities have set a policy for tobacco funding, BMJ 329 (2004), 9.


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